Listar BMB - Artículos por título
Mostrando ítems 10-29 de 41
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Characterizing the involvement of FaMADS9 in the regulation of strawberry fruit receptacle development
Vallarino, José G.; Merchante, Catharina; Sánchez-Sevilla, José F; De Luis Balaguer, Maria Angels; Pott, Delphine; Ariza, María T; Casañal, Ana; Posé, David; Vioque, Amalia; Amaya, Iraida; Willmitzer, Lothar; Solano, Roberto; Sozzani, Rosangela; Fernie, Alisdair R; Botella-Mesa, Miguel Angel
; Giovannoni, James J; Valpuesta-Fernandez, Victoriano; Osorio-Algar, Sonia[et al.] (Wiley Online Library, 2019-09-18)
FaMADS9 is the strawberry (Fragaria x ananassa) gene that exhibits the highest homology to the tomato (Solanum lycopersicum) RIN gene. Transgenic lines were obtained in which FaMADS9 was silenced. The fruits of these lines ... -
A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers
Marrero, Ana Dácil; Castilla, Laura; Espartero, José L.; Madrona, Andrés; Rodriguez-Quesada, Ana Maria; Medina, Miguel Ángel; Martinez-Poveda, Beatriz Amparo[et al.] (2020-09-22)
The phenolic compound hydroxytyrosol and its derivatives are responsible for some of the health benefits of the intake of virgin olive oil, having shown antiangiogenic properties. In this study, we explored the ... -
Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives
López-Jiménez, Auxiliadora; Gallardo, Elena; Espartero, José L.; Madrona, Andrés; Medina, Miguel Ángel; Rodriguez-Quesada, Ana Maria[et al.] (Royal Society of Chemistry, 2018)
Hydroxytyrosol is a phenolic compound present in extra virgin olive oil, either in free form or as derivatives, and related to some of the health benefits described for olive oil intake. We have demonstrated previously ... -
Control of tumor angiogenesis and metastasis through modulation of cell redox state
Serrano, José J.; Delgado, Belén; Medina, Miguel Ángel (2020-09-22)
Redox reactions pervade all biology. The control of cellular redox state is essential for bioenergetics and for the proper functioning of many biological functions. This review traces a timeline of findings regarding the ... -
Copper-containing mesoporous bioactive glass promotes angiogenesis in an in vivo zebrafish model
Romero-Sánchez, Lilian B.; Mari-Beffa, Manuel; Carrillo Fernández, Paloma; Medina, Miguel Ángel; Díaz-Cuenca, Aránzazu (2018-10-19)
The osteogenic and angiogenic responses of organisms to the ionic products of degradation of bioactive glasses (BGs) are being intensively investigated. The promotion of angiogenesis by copper (Cu) has been known for more ... -
Development and Validation of a Multilingual Lexicon as a Key Tool for the Sensory Analyses and Consumer Tests of Blueberry and Raspberry Fruit
Lippi, Nico; Senger, Elisa; Karhu, Saila; Mezzetti, Bruno; Cianciabella, Marta; Ayvaz Sönmez, Duygu; Fidelis, Marina; Gatti, Edoardo; Höfer, Monika; Ebru Kafkas, Nesibe; Mazzoni, Luca; McCallum, Susan; Olbricht, Klaus; Orsucci, Saverio; Osorio-Algar, Sonia; Pinczinger, Dora; Predieri, Stefano; Rokka, Susanna; Sánchez-Sevilla, José Federico; Savini, Gianluca; Soria, Carmen; Usadel, Björn; Zucchi, Paolo; Chiara, Medoro[et al.] (IOAP-MDPI, 2023-01-28)
A comprehensive lexicon is a necessary communication tool between the panel leader and panelists to describe each sensory stimulus potentially evoked by a product. In the current scientific breeding and trading scenario, ... -
Exploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursors
Cheng-Sánchez, Iván; Sánchez-Ruiz, Antonio; Martinez-Poveda, Beatriz Amparo; Medina, Miguel Ángel; Carrillo Fernández, Paloma; Rodriguez-Quesada, Ana Maria; López-Romero, Juan Manuel; Sarabia-Garcia, Francisco Ramon[et al.] (2018-10-19)
New synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized ... -
Fishing anti(lymph)angiogenic drugs with zebrafish
García-Caballero, Melissa; Rodriguez-Quesada, Ana Maria; Medina, Miguel Ángel; Mari-Beffa, Manuel (2018-10-19)
Zebrafish, an amenable small teleost fish with a complex mammal-like circulatory system, is being increasingly used for drug screening and toxicity studies. It combines the biological complexity of in vivo models with a ... -
Functional Analysis of TM6 MADS-box gene in the Octoploid Strawberry by CRISPR/Cas9 directed mutagenesis
(Oxford University Press, 2019-01)The B-class of MADS-box transcription factors has been studied in many plant species, but remains functionally unchar- acterized in Rosaceae. APETALA3 (AP3), a member of this class, controls petal and stamen identities in ... -
Functional Analysis of TM6 MADS-box gene in the Octoploid Strawberry by CRISPR/Cas9 directed mutagenesis
(bioRxiv, 2018-06-20)The B-class of MADS-box transcription factors has been studied in many plant species, but remain functionally uncharacterized in the Rosaceae family. APETALA3 (AP3), a member of this class, controls the identity of petals ... -
Gene expression atlas of fruit ripening and transcriptome assembly from RNA-seq data in octoploid strawberry (Fragaria × ananassa)
Sánchez-Sevilla, José F; Vallarino, José G.; Osorio-Algar, Sonia; Bombarely, Aureliano; Posé, David; Merchante, Catharina; Botella-Mesa, Miguel Angel; Amaya, Iraida; Valpuesta-Fernandez, Victoriano[et al.] (Springer Nature, 2017-10-23)
RNA-seq has been used to perform global expression analysis of the achene and the receptacle at four stages of fruit ripening, and of the roots and leaves of strawberry (Fragaria × ananassa). About 967 million reads and ... -
Genome Editing as a Tool for Fruit Ripening Manipulation
(Frontiers, 2018-09-25)Over the last few years, a series of tools for genome editing have been developed, allowing the introduction of precise changes into plant genomes. These have included Zinc-finger nucleases (ZFNs), transcription activator-like ... -
Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesis
García-Vilas, Javier A.; Rodriguez-Quesada, Ana Maria; Medina, Miguel Ángel (Elsevier, 2017-04)
The health benefits of olive oil are attributed to their bioactive compounds, such as hydroxytyrosol. Previously, we demonstrated that hydroxytyrosol inhibits angiogenesis in vitro. The present study aimed to: i) get further ... -
KinFams: De-Novo Classification of Protein Kinases Using CATH Functional Units
Adeyelu, Tolulope; Bordin, Nicola; Waman, Vaishali P.; Sadlej, Marta; Sillitoe, Ian; Moya-Garcia, Aurelio Angel; Orengo, Christine A.[et al.] (IOAP-MDPI, 2023-02-02)
Protein kinases are important targets for treating human disorders, and they are the second most targeted families after G-protein coupled receptors. Several resources provide classification of kinases into evolutionary ... -
Mathematical modeling of cancer metabolism
Medina, Miguel Ángel (2018-10-19)
Systemic approaches are needed and useful for the study of the very complex issue of cancer. Modeling has a central position in these systemic approaches. Metabolic reprogramming is nowadays acknowledged as an essential ... -
Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell Lines
de los Santos-Jiménez, Juan; Rosales, Tracy; Ko, Bookyung; Campos-Sandoval, Jose Angel; Alonso, Francisco J.; Márquez-Gómez, Javier; DeBerardinis, Ralph J; Mates-Sanchez, Jose Manuel[et al.] (IOAP-MDPI, 2023-01-15)
Glioblastoma multiforme is the most common primary brain tumor. Unfortunately, it is also one of the cancer types that has the worst morbidity and mortality ratios, so new targets and treatments need to be found. The ... -
Metabolic Reprogramming is a Hallmark of Metabolism Itself
Medina, Miguel Ángel (2020-09-23)
The reprogramming of metabolism has been identified as one of the hallmarks of cancer. It is becoming more and more frequent to connect other diseases with metabolic reprogramming. This article aims to argue that metabolic ... -
Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target
Martinez-Poveda, Beatriz Amparo; Medina, Miguel Ángel; Ocaña Farfán, María del Carmen; Rodriguez-Quesada, Ana Maria (2018-10-19)
Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed ... -
Network-Based Methods for Approaching Human Pathologies from a Phenotypic Point of View
(IOAP-MPDI, 2022-06-17)Network and systemic approaches to studying human pathologies are helping us to gain insight into the molecular mechanisms of and potential therapeutic interventions for human diseases, especially for complex diseases where ... -
Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity
Cárdenas, Casemiro; Torres-Vargas, José Antonio; Cárdenas Valdivia, Abel; Jurado, Nuria; Rodriguez-Quesada, Ana Maria; García-Caballero, Melissa; Martinez-Poveda, Beatriz Amparo; Medina Torres, Miguel Ángel[et al.] (ELSEVIER, 2021-11)
The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. ...