Listar BMB - Artículos por fecha de publicación
Mostrando ítems 1-20 de 56
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Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway
García-Caballero, Melissa; Blacher, S.; Pauper, J.; Rodríguez-Quesada, Ana María
; Medina-Torres, Miguel Ángel; Nöel, Agnes[et al.] (Wiley, 2016)
BACKGROUND AND PURPOSE Lymphangiogenesis is an important biological process associated with the pathogenesis of several diseases, including metastatic dissemination, graft rejection, lymphoedema and other inflammatory ... -
Screening of Synergistic Interactions of Epigallocatechin-3-gallate with Antiangiogenic and Antitumor Compounds
Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; García-Vilas García, Javier Alejandro (Elsevier, 2016-07)
Purpose: To screen for possible synergistic interactions of epigallocatechin-3-gallate (EGCG) with a selection of 10 anti-angiogenic or anti-tumor compounds on the survival of endothelial and tumor cells. Methods: Human ... -
The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects
García-Vilas, Javier A.; Pino-Ángeles, Almudena; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (Elsevier, 2017-01)
The natural bioactive compound damnacanthal inhibits several tyrosine kinases. Herein, we show that -in fact- damancanthal is a multi kinase inhibitor. A docking and molecular dynamics simulation approach allows getting ... -
Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesis
García-Vilas, Javier A.; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (Elsevier, 2017-04)
The health benefits of olive oil are attributed to their bioactive compounds, such as hydroxytyrosol. Previously, we demonstrated that hydroxytyrosol inhibits angiogenesis in vitro. The present study aimed to: i) get further ... -
Gene expression atlas of fruit ripening and transcriptome assembly from RNA-seq data in octoploid strawberry (Fragaria × ananassa)
Sánchez-Sevilla, José F; Vallarino Castro, José G.; Osorio-Algar, Sonia; Bombarely, Aureliano; Pose-Padilla, David; Merchante-Berg, Catharina; Botella-Mesa, Miguel Ángel; Amaya Saavedra, Iraida; Valpuesta-Fernández, Victoriano[et al.] (Springer Nature, 2017-10-23)
RNA-seq has been used to perform global expression analysis of the achene and the receptacle at four stages of fruit ripening, and of the roots and leaves of strawberry (Fragaria × ananassa). About 967 million reads and ... -
Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives
López-Jiménez, Auxiliadora; Gallardo, Elena; Espartero, José L.; Madrona, Andrés; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María[et al.] (Royal Society of Chemistry, 2018)
Hydroxytyrosol is a phenolic compound present in extra virgin olive oil, either in free form or as derivatives, and related to some of the health benefits described for olive oil intake. We have demonstrated previously ... -
Functional Analysis of TM6 MADS-box gene in the Octoploid Strawberry by CRISPR/Cas9 directed mutagenesis
Martín-Pizarro, Carmen; Triviño, Juan Carlos; Pose-Padilla, David (bioRxiv, 2018-06-20)
The B-class of MADS-box transcription factors has been studied in many plant species, but remain functionally uncharacterized in the Rosaceae family. APETALA3 (AP3), a member of this class, controls the identity of petals ... -
(+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells
García-Vilas García, Javier Alejandro; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (IOAP-MPDI, 2018-09-06)
The bioactive natural compound from marine origin, (+)-aeroplysinin-1, has been shown to exhibit potent anti-inflammatory and anti-angiogenic effects. The aim of the present study was to identify new targets for ... -
Genome Editing as a Tool for Fruit Ripening Manipulation
Martín-Pizarro, Carmen; Pose-Padilla, David (Frontiers, 2018-09-25)
Over the last few years, a series of tools for genome editing have been developed, allowing the introduction of precise changes into plant genomes. These have included Zinc-finger nucleases (ZFNs), transcription activator-like ... -
Mathematical modeling of cancer metabolism
Medina-Torres, Miguel Ángel (2018-10-19)
Systemic approaches are needed and useful for the study of the very complex issue of cancer. Modeling has a central position in these systemic approaches. Metabolic reprogramming is nowadays acknowledged as an essential ... -
Copper-containing mesoporous bioactive glass promotes angiogenesis in an in vivo zebrafish model
Romero-Sánchez, Lilian B.; Marí-Beffa, Manuel; Carrillo Fernández, Paloma; Medina-Torres, Miguel Ángel; Díaz-Cuenca, Aránzazu (2018-10-19)
The osteogenic and angiogenic responses of organisms to the ionic products of degradation of bioactive glasses (BGs) are being intensively investigated. The promotion of angiogenesis by copper (Cu) has been known for more ... -
Fishing anti(lymph)angiogenic drugs with zebrafish
García-Caballero, Melissa; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Marí-Beffa, Manuel (2018-10-19)
Zebrafish, an amenable small teleost fish with a complex mammal-like circulatory system, is being increasingly used for drug screening and toxicity studies. It combines the biological complexity of in vivo models with a ... -
Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target
Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Ocaña Farfán, María del Carmen; Rodríguez-Quesada, Ana María (2018-10-19)
Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed ... -
Exploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursors
Cheng-Sánchez, Iván; Sánchez-Ruiz, Antonio; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Carrillo Fernández, Paloma; Rodríguez-Quesada, Ana María; López-Romero, Juan Manuel; Sarabia-García, Francisco Ramón[et al.] (2018-10-19)
New synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized ... -
Functional Analysis of TM6 MADS-box gene in the Octoploid Strawberry by CRISPR/Cas9 directed mutagenesis
Martín-Pizarro, Carmen; Triviño, Juan Carlos; Pose-Padilla, David (Oxford University Press, 2019-01)
The B-class of MADS-box transcription factors has been studied in many plant species, but remains functionally unchar- acterized in Rosaceae. APETALA3 (AP3), a member of this class, controls petal and stamen identities in ... -
Characterizing the involvement of FaMADS9 in the regulation of strawberry fruit receptacle development
Vallarino Castro, José G.; Merchante-Berg, Catharina; Sánchez-Sevilla, José F; De Luis Balaguer, María Angels; Pott, Delphine; Ariza Fernández, María Teresa; Casañal, Ana; Pose-Padilla, David; Vioque, Amalia; Amaya Saavedra, Iraida; Willmitzer, Lothar; Solano, Roberto; Sozzani, Rosangela; Fernie, Alisdair R; Botella-Mesa, Miguel Ángel; Giovannoni, James J; Valpuesta-Fernández, Victoriano; Osorio-Algar, Sonia[et al.] (Wiley Online Library, 2019-09-18)
FaMADS9 is the strawberry (Fragaria x ananassa) gene that exhibits the highest homology to the tomato (Solanum lycopersicum) RIN gene. Transgenic lines were obtained in which FaMADS9 was silenced. The fruits of these lines ... -
Allelic Variation of MYB10 is the Major Force Controlling Natural Variation of Skin and Flesh Color in Strawberry (Fragaria spp.) fruit
Castillejo, Cristina; Waurich, Veronika; Wagner, Henning; Ramos, Rubén; Oiza, Nicolás; Muñoz, Pilar; Triviño, Juan C; Caruana, Julie; Liu, Zhongchi; Cobo, Nicolás; Hardigan, Michael A; Knapp, Steven J; Vallarino Castro, José G.; Osorio-Algar, Sonia; Martín-Pizarro, Carmen; Pose-Padilla, David; Toivainen, Tuomas; Hytönen, Timo; Oh, Youngjae; Barbey, Christopher R; Whitaker, Vance M; Lee, Seonghee; Olbricht, Klaus; Sánchez-Sevilla, José F; Amaya Saavedra, Iraida[et al.] (2020-06-13)
Anthocyanins are the principal color-producing compounds synthesized in developing fruits of strawberry (Fragaria spp.). Substantial natural variation in color have been observed in fruits of diploid and octoploid accessions, ... -
Control of tumor angiogenesis and metastasis through modulation of cell redox state
Serrano, José J.; Delgado-Martín, Belén; Medina-Torres, Miguel Ángel (2020-09-22)
Redox reactions pervade all biology. The control of cellular redox state is essential for bioenergetics and for the proper functioning of many biological functions. This review traces a timeline of findings regarding the ... -
A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers
Marrero, Ana Dácil; Castilla, Laura; Espartero, José L.; Madrona, Andrés; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Martínez-Póveda, Beatriz Amparo[et al.] (2020-09-22)
The phenolic compound hydroxytyrosol and its derivatives are responsible for some of the health benefits of the intake of virgin olive oil, having shown antiangiogenic properties. In this study, we explored the ... -
Metabolic Reprogramming is a Hallmark of Metabolism Itself
Medina-Torres, Miguel Ángel (2020-09-23)
The reprogramming of metabolism has been identified as one of the hallmarks of cancer. It is becoming more and more frequent to connect other diseases with metabolic reprogramming. This article aims to argue that metabolic ...