BMB - Artículos: Envíos recientes
Mostrando ítems 1-20 de 33
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Network-Based Methods for Approaching Human Pathologies from a Phenotypic Point of View
(IOAP-MPDI, 2022-06-17)Network and systemic approaches to studying human pathologies are helping us to gain insight into the molecular mechanisms of and potential therapeutic interventions for human diseases, especially for complex diseases where ... -
Turning around Cycles: An Approach Based on Selected Problems/Cases to Stimulate Collaborative Learning about Krebs and His Four Metabolic Cycles
(ACS, 2022-05-25)Metabolism is a challenging subject for bioscience students due to the intrinsic complexity of the metabolic network, as well as that of the overlapping mechanisms of metabolic regulation. Collaborative learning based on ... -
Secretory Profile of Adipose-Tissue-Derived Mesenchymal Stem Cells from Cats with Calicivirus-Positive Severe Chronic Gingivostomatitis
(IOAP-MPDI, 2022-05-25)The feline calicivirus (FCV) causes infections in cats all over the world and seems to be related to a broad variety of clinical presentations, such as feline chronic gingivostomatitis (FCGS), a severe oral pathology in ... -
(+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells
(IOAP-MPDI, 2018-09-06)The bioactive natural compound from marine origin, (+)-aeroplysinin-1, has been shown to exhibit potent anti-inflammatory and anti-angiogenic effects. The aim of the present study was to identify new targets for ... -
Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity
(ELSEVIER, 2021-11)The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. ... -
A revised view on the evolution of glutamine synthetase isoenzymes in plants
(Wiley, 2022-02)Glutamine synthetase (GS) is a key enzyme responsible for the incorporation of inorganic nitrogen in the form of ammonium into the amino acid glutamine. In plants, two groups of functional GS enzymes are found: eubacterial ... -
Bringing Light to Science Undergraduate Students: A Successful Laboratory Experiment Illustrating the Principles and Applications of Bioluminescence
(ACS Publications, 2021)Although many laboratory experiments are available to illustrate spectrophotometric or fluorometric methods, few of them introduce the use of luminometry to students. Bioluminescence, a subtype of chemiluminescence, ... -
Synthesis, characterization and biological evaluation of octyltrimethylammonium tetrathiotungstate
(Springer Nature, 2021)Octyltrimethylammonium tetrathiotungstate salt (ATT-C8) was synthesized and its ability to chelate copper was evaluated. The biological and toxic aspects were evaluated by in vitro and in vivo assays, using bovine aorta ... -
Sustainability in the management of scientific information
(Springer Nature, 2020-09-25)The sustainability in the management of scientific information is becoming compromised in this new age of Big Data. Herein, I present and discuss some of the main challenges of this situation in both scientific practice ... -
Characterizing the involvement of FaMADS9 in the regulation of strawberry fruit receptacle development
(Wiley Online Library, 2019-09-18)FaMADS9 is the strawberry (Fragaria x ananassa) gene that exhibits the highest homology to the tomato (Solanum lycopersicum) RIN gene. Transgenic lines were obtained in which FaMADS9 was silenced. The fruits of these lines ... -
Functional Analysis of TM6 MADS-box gene in the Octoploid Strawberry by CRISPR/Cas9 directed mutagenesis
(Oxford University Press, 2019-01)The B-class of MADS-box transcription factors has been studied in many plant species, but remains functionally unchar- acterized in Rosaceae. APETALA3 (AP3), a member of this class, controls petal and stamen identities in ... -
The NAC transcription factor FaRIF controls fruit ripening in strawberry
(Oxford University Press, 2021-02-24)In contrast to climacteric fruits such as tomato, the knowledge on key regulatory genes controlling the ripening of straw- berry, a nonclimacteric fruit, is still limited. NAC transcription factors (TFs) mediate different ... -
Genome Editing as a Tool for Fruit Ripening Manipulation
(Frontiers, 2018-09-25)Over the last few years, a series of tools for genome editing have been developed, allowing the introduction of precise changes into plant genomes. These have included Zinc-finger nucleases (ZFNs), transcription activator-like ... -
Allelic Variation of MYB10 is the Major Force Controlling Natural Variation of Skin and Flesh Color in Strawberry (Fragaria spp.) fruit
(2020-06-13)Anthocyanins are the principal color-producing compounds synthesized in developing fruits of strawberry (Fragaria spp.). Substantial natural variation in color have been observed in fruits of diploid and octoploid accessions, ... -
Functional Analysis of TM6 MADS-box gene in the Octoploid Strawberry by CRISPR/Cas9 directed mutagenesis
(bioRxiv, 2018-06-20)The B-class of MADS-box transcription factors has been studied in many plant species, but remain functionally uncharacterized in the Rosaceae family. APETALA3 (AP3), a member of this class, controls the identity of petals ... -
Gene expression atlas of fruit ripening and transcriptome assembly from RNA-seq data in octoploid strawberry (Fragaria × ananassa)
(Springer Nature, 2017-10-23)RNA-seq has been used to perform global expression analysis of the achene and the receptacle at four stages of fruit ripening, and of the roots and leaves of strawberry (Fragaria × ananassa). About 967 million reads and ... -
Ammonium regulates the development of pine roots through hormonal crosstalk and differential expression of transcription factors in the apex
(Wiley, 2021-11-01)Ammonium is a prominent source of inorganic nitrogen for plant nutrition, but excessive amounts can be toxic for many species. However, most conifers are tolerant to ammonium, a relevant physiological feature of this ancient ... -
Autophagy is required for strawberry fruit ripening
(Frontiers Media SA, 2021-08-27)Autophagy is a catabolic and recycling pathway that maintains cellular homeostasis under normal growth and stress conditions. Two major types of autophagy, microautophagy and macroautophagy, have been described in plants. ... -
Antioxidant responses related to temozolomide resistance in glioblastoma
(Elsevier, 2021)Glioblastoma remains one of the most challenging and devastating cancers, with only a very small proportion of patients achieving 5-year survival. The current standard of care consists of surgery, followed by radiation ... -
Metabolic Reprogramming is a Hallmark of Metabolism Itself
(2020-09-23)The reprogramming of metabolism has been identified as one of the hallmarks of cancer. It is becoming more and more frequent to connect other diseases with metabolic reprogramming. This article aims to argue that metabolic ...