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dc.contributor.authorMañas Padilla, Mª Carmen
dc.contributor.authorÁvila-Gámiz, Fabiola
dc.contributor.authorGil Rodríguez, Sara
dc.contributor.authorLadrón de Guevara-Miranda, David
dc.contributor.authorRodríguez de Fonseca, Fernando
dc.contributor.authorSantin-Nuñez, Luis Javier 
dc.contributor.authorCastilla-Ortega, Estela
dc.date.accessioned2021-09-10T09:26:00Z
dc.date.available2021-09-10T09:26:00Z
dc.date.created2021
dc.date.issued2021
dc.identifier.citation49th Meeting of the European Brain and Behaviour Society (EBBS)es_ES
dc.identifier.urihttps://hdl.handle.net/10630/22817
dc.descriptionPSI2017-82604; PRE2018-085673; I Plan Propio de Investigación, Transferencia y Divulgación Científica de la Universidad de Málagaes_ES
dc.description.abstractLasting neurobehavioral adaptations such as cognitive decline are induced by chronic cocaine exposure in animal models. However, persistent changes in motor and exploratory responses are rarely reported. In this study, mice were administered a cocaine dose (COC, 20 mg/kg/day) or saline (SAL) repeatedly for 12 consecutive days in their home cage. After 24 days of drug withdrawal, they were submitted to a behavioral test battery to assess motor/exploratory activity and anxiety-like behavior (elevated plus maze and open field tests), behavioral despair (forced swimming test), working and reference memory (spontaneous alternation behavior –SAB- and novel place recognition memory tests). This behavioral assessment was carried out in drug-free conditions and in unfamiliar environments, so no cocaine-associated stimuli were presented. The cocaine-withdrawn mice showed cognitive deficits in spontaneous alternation behavior and place recognition memory. Importantly, they also displayed hyperlocomotion, increased rearing activity and altered exploratory patterns in different tasks. In the forced swimming test, they were more active (struggled/climbed more) when trying to escape from the water albeit showing similar immobility behavior than controls. In conclusion, in addition to cognitive deficits, chronic cocaine may induce lasting changes in psychomotor activation even in unfamiliar environments not associated to the drug. This outcome may be influenced by factors related to exploration, energy or emotionality.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectConductaes_ES
dc.subject.otherCocainees_ES
dc.subject.otherBehavioures_ES
dc.subject.otherMicees_ES
dc.subject.otherCognitiones_ES
dc.titleCognitive impairment and persistent changes in exploration and hyperactivity in mice after withdrawn from chronic cocainees_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Psicologíaes_ES
dc.relation.eventtitle49th Meeting of the European Brain and Behaviour Society (EBBS)es_ES
dc.relation.eventplaceLausanne, Switzerlandes_ES
dc.relation.eventdate4th - 8th September 2021es_ES


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