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Anti-inflammatory potential of aeroplysinin-1, a bioactive compound isolated from the sponge Aplysina aerophoba
dc.contributor.author | Bravo-Ruiz, Inés | |
dc.contributor.author | Bernal, Manuel | |
dc.contributor.author | Manrique-Poyato, Maria Inmaculada | |
dc.contributor.author | Rodríguez-Quesada, Ana María | |
dc.contributor.author | Medina-Torres, Miguel Ángel | |
dc.contributor.author | Castilla, Laura | |
dc.contributor.author | Martínez-Póveda, Beatriz Amparo | |
dc.date.accessioned | 2021-09-20T09:50:41Z | |
dc.date.available | 2021-09-20T09:50:41Z | |
dc.date.created | 2021 | |
dc.date.issued | 2021 | |
dc.identifier.uri | https://hdl.handle.net/10630/22856 | |
dc.description | Contribución a Congreso (póster) | es_ES |
dc.description.abstract | Aeroplysinin-1 (Apl-1) is a brominated compound isolated from the marine sponge Aplysina aerophoba that has been shown to possess bioactive effects with a broad spectrum of action in in vitro and in vivo assays. Included in its pleiotropic activity are anti-tumor, anti-angiogenic, pro-apoptotic [1] and anti-oxidant effects [2], making Apl-1 a natural compound with very promising properties for its use as a potential therapeutic agent. In addition to the aforementioned effects, our group explored the role of Apl-1 in inflammation, a process related to numerous highly prevalent pathologies, such as cancer and atherosclerosis, showing the first evidence of its anti-inflammatory potential [3]. In this work, our group delves into the anti-inflammatory effect of Apl-1 in the context of vascular endothelium and provides new data regarding the molecular mechanism underlying this activity. The characterization of the mechanism of action points to the modulatory effect of Apl-1 on pathways involved in endothelial activation during the development of inflammation, experimental evidence that opens the door to the potential use of this compound as an anti-inflammatory agent. | es_ES |
dc.description.sponsorship | Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. This work is supported by funds from projects PID2019-105010RB-100 (Ministry of Science, Government of Spain), UMA18-FEDERJA-220 (Junta de Andalucía and FEDER funds), and funds from the BIO-267 group (Junta de Andalucía). M.B. is supported by a Juan de la Cierva fellowship (Government of Spain). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | 43 Congreso Anual SEBBM | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Medicamentos - Congresos | es_ES |
dc.subject.other | Aeroplysinin-1 | es_ES |
dc.title | Anti-inflammatory potential of aeroplysinin-1, a bioactive compound isolated from the sponge Aplysina aerophoba | es_ES |
dc.type | info:eu-repo/semantics/conferenceObject | es_ES |
dc.centro | Facultad de Ciencias | es_ES |
dc.relation.eventtitle | 43 Congreso Anual de la Sociedad Española de Bioquímica y Biología Molecular | es_ES |
dc.relation.eventplace | Barcelona | es_ES |
dc.relation.eventdate | Julio 2021 | es_ES |