Listar COG - Artículos por título
Mostrando ítems 1-20 de 61
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A metagenome-wide association study of HIV disease progression in HIV controllers.
(Elsevier, 2023)Some HIV controllers experience immunologic progression with CD4+ T cell decline. We aimed to identify genetic factors associated with CD4+ T cell lost in HIV controllers. A total of 561 HIV controllers were included, 442 ... -
Age related changes in the bone microstructure in patients with femoral neck fractures.
(Elsevier, 2020-02-16)Background The objective of this study was to analyze the correlation between various bone structural features and age. Study Design & Methods A total of 29 consecutive patients who suffered an intracapsular hip fracture ... -
An intragenic duplication within SIRPβ1 shows a dual effect over Alzheimer’s disease cognitive decline altering the microglial response.
(SAGE, 2024)Microglia play an important role in the maintenance of brain homeostasis, and microglial dysfunction plays a causative role in Alzheimer disease pathogenesis. Here we focus on the signal regulatory protein SIRPβ1, a surface ... -
Anticlusterin treatment of breast cancer cells increases the sensitivities of chemotherapy and tamoxifen and counteracts the inhibitory action of dexamethasone on chemotherapy-induced cytotoxicity
(BMC Springer Nature, 2007-12-13)Introduction: Overexpression of the apoptosis-related protein clusterin is associated with breast cancer development and tumor progression. We describe the use of clusterin-specific antisense oligonucleotides and antibodies ... -
Calcium Homeostasis in the Development of Resistant Breast Tumors.
(MDPI, 2023-05-23)Cancer is one of the main health problems worldwide. Only in 2020, this disease caused more than 19 million new cases and almost 10 million deaths, with breast cancer being the most diagnosed worldwide. Today, despite ... -
Cambios emocionales y alteraciones en la Inmunoglobulina A (IgA) tras el tratamiento psicológico en mujeres víctimas de violencia doméstica
(Universidad de Murcia, 2012)El objetivo de este estudio ha sido determinar, en mujeres víctimas de maltrato, los beneficios de un tratamiento psicológico y evaluar su impacto en la salud psicológica y en el sistema inmune. Las participantes fueron ... -
Changes of Body Composition in Patients with BMI 23–50 After Tailored One Anastomosis Gastric Bypass (BAGUA): Influence of Diabetes and Metabolic Syndrome
(Springer Nature, 2014)We studied 79 (37 diabetic and 42 non-diabetic) patients (BMI 23–50) who completed all evaluation appointment (preoperative, 10 days, 1, 3, 6, and 12 months) after tailored BAGUA for obesity, diabetes, or diabesity. Patients ... -
Comparative Clinical Study of Different Multiplex Real Time PCR Strategies for the Simultaneous Differential Diagnosis between Extrapulmonary Tuberculosis and Focal Complications of Brucellosis.
(PLOS, 2013-12-12)Background Both brucellosis and tuberculosis are chronic-debilitating systemic granulomatous diseases with a high incidence in many countries in Africa, Central and South America, the Middle East and the Indian subcontinent. ... -
Composition and characteristics of trabecular bone in osteoporosis and osteoarthritis.
(Elsevier, 2020-08-12)Purpose: The aim of this study was to analyze trabecular bone architecture, and its crystal and organic composition in humans, by comparing samples taken from patients who had a hip fracture (HF) and individuals with hip ... -
Construction of a Prognostic Score for Ultrasound Evaluation of the Transobturator Sling for Stress Urinary Incontinence
(MDPI, 2022-02-27)Currently, pelvic floor ultrasound allows us to correctly visualize the synthetic material used in stress urinary incontinence surgery. The objective of this study is the construction of a score and its correlation with ... -
Cost-effectiveness analysis of the Geriatric Fracture Center (GFC) concept: a prospective multicentre cohort study
(BMJ Journals, 2023-11-02)Introduction: Geriatric Fracture Centers (GFCs) are dedicated treatment units where care is tailored towards elderly patients who have suffered fragility fractures. The primary objective of this economic analysis was to ... -
d-Pinitol promotes tau dephosphorylation through a cyclin-dependent kinase 5 regulation mechanism: A new potential approach for tauopathies?
(WILEY, 2022-06-27)Background and Purpose Recent evidence links brain insulin resistance with neurodegenerative diseases, where hyperphosphorylated tau protein contributes to neuronal cell death. In the present study, we aimed to evaluate ... -
Detection methods predict differences in biology and survival in breast cancer patients
(BMC Springer Nature, 2012)Background: The aim of this study was to measure the biological characteristics involved in tumorigenesis and the progression of breast cancer in symptomatic and screen-detected carcinomas to identify possible difference ... -
Detection of Relevant Heavy Metal Concentrations in Human Placental Tissue: Relationship between the Concentrations of Hg, As, Pb and Cd and the Diet of the Pregnant Woman
(IOAP-MPDI, 2022-11-09)Heavy metals can cross the placental barrier and reach the fetal compartment, threatening fetal development. Pregnant women can acquire these through food, drinking water, toxic habits or simply by breathing polluted air. ... -
Development of a Novel NGS Methodology for Ultrasensitive Circulating Tumor DNA Detection as a Tool for Early-Stage Breast Cancer Diagnosis
(IOAP-MDPI, 2022-12-21)Breast cancer (BC) is the most prevalent cancer in women. While usually detected when localized, invasive procedures are still required for diagnosis. Herein, we developed a novel ultrasensitive pipeline to detect circulating ... -
Development of trauma systems in Europe-reports from England, Germany, the Netherlands, and Spain
(Orthopaedic Trauma Association, 2019)Major trauma systems have evolved in many European countries and have resulted in improved care in terms of mortality and morbidity. Many of the systems have similar history, with reports of either poor services, or a ... -
Differential behavior of serum and red blood cell folate during a treatment with levofolinic acid. Gender differences.
(Clinical Laboratory Publications, 2014-01-01)Background: Folates are essential nutrients that maintain nucleotide synthesis and methylation reactions. Folate levels depend essentially on the diet. In the present work, the changes in the folate-homocysteine (Hcy) ... -
Disociación espinopélvica, revisión de conceptos actuales
(2024)Introducción La disociación espinopélvica es una lesión muy poco frecuente, pero también muy grave, ya que puede asociar importantes complicaciones con una elevada morbimortalidad. Su baja frecuencia provoca que la ... -
Downregulation of clusterin mediates sensitivity to protein kinase inhibitors in breast cancer cells.
(Lipincott, 2015)The efficacy of protein kinase inhibitors (PKIs) has been shown in clinical assays for cancer, but as isolated agents, they only have a modest effect. One of the most important characteristics of mitogen-activated PKIs is ... -
Expression of the Antiapoptotic Proteins Clusterin and Bcl-2 in Laryngeal Squamous Cell Carcinomas
(Karger, 2006)Bcl-2 and clusterin genes have been related to the inhibition of apoptosis, an event that plays a key role in malignant transformation and in invasive disease. In this work, we determine the significance of clusterin and ...