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dc.contributor.authorNarváez, Manuel 
dc.contributor.authorAndrade-Talavera, Yuniesky
dc.contributor.authorFores-POns, Ramon
dc.contributor.authorValladolid-Acebes, Ismael
dc.contributor.authorSiegele, Pia
dc.contributor.authorHernandez-Sosa, Alejandro
dc.contributor.authorFisahn, Andre
dc.contributor.authorLópez-Salas, Alexander
dc.contributor.authorBorroto-Escuela, Dasiel
dc.contributor.authorNarvaez
dc.date.accessioned2021-11-08T11:10:05Z
dc.date.available2021-11-08T11:10:05Z
dc.date.created2021-11-04
dc.date.issued2021-11-04
dc.identifier.urihttps://hdl.handle.net/10630/23175
dc.description.abstractThe majority of the fibroblast growth factor receptor 1-serotonin 1 A receptor (FGFR1-5-HT1AR) heterocomplexes in the hippocampus appeared to be located mainly in the neuronal networks and a relevant target for antidepressant drugs. Through a neurochemical and electrophysiological analysis it was therefore tested in the current study if astrocytic FGFR1-5-HT1AR heterocomplexes also exist in hippocampus. They may modulate the structure and function of astroglia in the hippocampus leading to possible changes in the gamma oscillations. Localization of hippocampal FGFR1-5-HT1AR heterocomplexes in astrocytes was found using in situ proximity ligation assay combined with immunohistochemistry using glial fibrillary acidic protein (GFAP) immunoreactivity as a marker for astroglia. Acute i.c.v. treatment with 8-OH-DPAT alone or together with basic fibroblast growth factor (FGF2) significantly increased FGFR1-5-HT1AR heterocomplexes in the GFAP positive cells, especially in the polymorphic layer of the dentate gyrus (PoDG) but also in the CA3 area upon combined treatment. No other hippocampal regions were studied. Also, structural plasticity changes were observed in the astrocytes, especially in the PoDG region, upon these pharmacological treatments. They may also be of relevance for enhancing the astroglial volume transmission with increased modulation of the neuronal networks in the regions studied. The effects of combined FGF2 and 5-HT agonist treatments on gamma oscillations point to a significant antagonistic interaction in astroglial FGFR1-5-HT1AR heterocomplexes that may contribute to counteraction of the 5-HT1AR-mediated decrease of gamma oscillations.es_ES
dc.description.sponsorshipThe work was supported by the Swedish Medical Research Council, Sweden (62X-00715-50-3) to KF, by Parkinson Fonden, Sweden to KF, and by Hjärnfonden, Sweden (F02018-0286), Hjärnfonden, Sweden (F02019-0296) and Karolinska Institutet Forskningsstiftelser, Sweden to D.O.B-E. D.O.B-E belongs to the “Academia de Biólogos Cubanos” group, Cuba. This work was also supported by the Proyecto Puente, Spain and the UMA18-FEDERJA-100, Spain to MN. . Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDepresiónes_ES
dc.subject.otherFGFR1-5-HT1ARes_ES
dc.subject.otherHeteroreceptor complexeses_ES
dc.subject.otherDepressiones_ES
dc.subject.otherHippocampal astrocyteses_ES
dc.titleExistence of FGFR1-5-HT1AR heteroreceptor complexes in hippocampal astrocytes. Putative link to 5-HT and FGF2 modulation of hippocampal gamma oscillationses_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Medicinaes_ES
dc.relation.eventtitle19 SENC meeting LLeidaes_ES
dc.relation.eventplaceLleidaes_ES
dc.relation.eventdate3-11-2021es_ES
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*


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