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dc.contributor.authorCarrillo-Franco, Laura
dc.contributor.authorLópez-González, Manuel Víctor 
dc.contributor.authorGonzález-García, Marta
dc.contributor.authorDíaz-Casares, Amelia 
dc.contributor.authorDawid-Milner, Marc Stefan 
dc.date.accessioned2021-11-11T14:59:51Z
dc.date.available2021-11-11T14:59:51Z
dc.date.created2021
dc.date.issued2021-11
dc.identifier.urihttps://hdl.handle.net/10630/23206
dc.description.abstractThe aim of this study was to characterise the relationship between mesencephalic-pontine neuronal circuits to understand their role in laryngeal control and its effect on vocalization. Methods: Experimental studies were carried out with non-inbred male rats (n=7), SPF, Sprague-Dawley (300-350 g) housed under standard conditions. Animals were anesthetized with sodium pentobarbitone (60 mg/kg i.p., initial dose, supplemented 2 mg/ kg, i.v., as necessary). A double tracheal cannulation (upwards in direction of the glottis for the “glottis isolated in situ” technique, and downwards in the direction of the carina) was done. Subglottic pressure was recorded with a precision differential pressure transducer (ADInstrument model FE141, ± 0,03 psi) by passing a stream of humidified medical air upwards through the larynx at a constant rate of 30-70 ml/min with a thermal mass digital air flow meter controller (Bronkhorst Hi-Tec F-201CV-AGD-22-V). Electrical stimulation of the CnF using concentric bipolar electrodes (1 ms pulses, 20-40 µA, 100 Hz for 5 s) was performed. Respiratory flow, pleural pressure, blood pressure, heart rate and ECG activity were also recorded. Results: CnF stimulation evoked a decrease of laryngeal resistance (subglottal pressure) (p<0,01) accompanied with an inspiratory facilitatory response consisted of an increase in respiratory rate (p<0,01), together with a pressor (p<0,001) and a tachycardic response (p<0,01). Conclusions: The results of our study contribute with new data on the role of the CnF in the mechanisms controlling subglottic pressure and laryngeal activity.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isospaes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectNeuronas motorases_ES
dc.subjectVocalizaciónes_ES
dc.subjectLaringees_ES
dc.subject.otherSubglottic Pressurees_ES
dc.subject.otherLaryngeal Motoneuronses_ES
dc.subject.othercuneiform nucleuses_ES
dc.titleLaryngeal effects of stimulation of the cuneiform nucleus (CnF) in spontaneously breathing anaesthetized ratses_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Medicinaes_ES
dc.relation.eventtitle19th Meeting of the Spanish Society of Neurosciencees_ES
dc.relation.eventplaceLleidaes_ES
dc.relation.eventdate03-11-2021es_ES


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