Mostrar el registro sencillo del ítem

dc.contributor.authorGago-Calderón, Belén 
dc.contributor.authorReal-Avilés, María Ángeles 
dc.contributor.authorPonce-Velasco, Marina
dc.contributor.authorRivera-Ramírez, Alicia 
dc.date.accessioned2021-11-12T12:27:23Z
dc.date.available2021-11-12T12:27:23Z
dc.date.created2021
dc.date.issued2021
dc.identifier.urihttps://hdl.handle.net/10630/23214
dc.description.abstractIn the adult mammalian brain, neuroblasts from the subventricular zone (SVZ) migrate along the rostral migratory stream into the olfactory bulb, where they differentiate and synaptically integrate to contribute with the maintenance of the olfactory function. It has been established that endogenous as well as exogenous opioid signalling affects proliferation in adult brains. In fact, chronic administration of morphine reduces adult neurogenesis in SVZ although its implication in addiction has not yet been clarified. On other hand, dopamine has been also identified as a regulatory factor of adult neurogenesis as dopaminergic cells from the substantia nigra compacta project toward the dorsal SVZ whereas the ventral tegmental area innervates the ventral SVZ. Previous results demonstrated that morphine increases striatal dopamine signaling, which is restored by the specific stimulation of dopamine D4 receptor (D4R). The mechanisms by which D4R counteracts morphine effects is not completely understood, but the existence of a D4R-MOR heterodimer in the striosomes of the caudate putamen has been proposed . However, it is unknown how this interaction could affect both the adult neurogenesis and olfaction. In the present work, we have studied the effects of a chronic treatment with morphine alone or in combination with a D4R agonist (PD168,077) on adult neurogenesis occurring in the SVZ. Furthermore, the impairment or improvement of odorants discrimination has also been analyzed. Using immunohistochemical techniques, we found that chronic treatment with morphine increases dopamine signalling in the SVZ and promotes a depletion of cell proliferation, affecting both neural and glial precursors. These effects were counteracted by the coadministration of morphine with the D4R agonist. The present results support for a critical role of the D4R to prevent morphine effects in the SVZ.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectDopaminaes_ES
dc.subjectNeurobiología del desarrolloes_ES
dc.subject.otherDopaminees_ES
dc.subject.otherStriatumes_ES
dc.subject.otherAddictiones_ES
dc.subject.otherNeurogenesises_ES
dc.titleDopamine D4R restores morphine-induced impairment of adult neurogenesis in the subventricular zonees_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitle19th National Meeting of the Spanish Society of Neurosciencees_ES
dc.relation.eventplaceLleidaes_ES
dc.relation.eventdatenoviembre 2021es_ES


Ficheros en el ítem

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem