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dc.contributor.authorSegovia-Zafra, Antonio
dc.contributor.authorDi Zeo-Sánchez, Daniel Enrique
dc.contributor.authorLópez-Gómez, Carlos
dc.contributor.authorPérez-Valdés, Zeus
dc.contributor.authorGarcía-Fuentes, Eduardo
dc.contributor.authorAndrade-Bellido, Raul Jesus 
dc.contributor.authorLucena-González, María Isabel 
dc.contributor.authorVillanueva-Paz, Marina
dc.date.accessioned2022-01-14T09:40:57Z
dc.date.available2022-01-14T09:40:57Z
dc.date.issued2021-12
dc.identifier.citationSegovia-Zafra A, Di Zeo-Sánchez DE, López-Gómez C, Pérez-Valdés Z, García-Fuentes E, Andrade RJ, Lucena MI, Villanueva-Paz M. Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction. Acta Pharm Sin B. 2021 Dec;11(12):3685-3726. doi: 10.1016/j.apsb.2021.11.013.es_ES
dc.identifier.urihttps://hdl.handle.net/10630/23614
dc.description.abstractIdiosyncratic drug-induced liver injury (iDILI) encompasses the unexpected harms that pre- scription and non-prescription drugs, herbal and dietary supplements can cause to the liver. iDILI remains a major public health problem and a major cause of drug attrition. Given the lack of biomarkers for iDILI prediction, diagnosis and prognosis, searching new models to predict and study mechanisms of iDILI is necessary. One of the major limitations of iDILI preclinical assessment has been the lack of correlation between the markers of hepatotoxicity in animal toxicological studies and clinically significant iDILI. Thus, major advances in the understanding of iDILI susceptibility and pathogenesis have come from the study of well-phenotyped iDILI patients. However, there are many gaps for explaining all the complexity of iDILI susceptibility and mechanisms. Therefore, there is a need to optimize preclinical hu- man in vitro models to reduce the risk of iDILI during drug development. Here, the current experimental models and the future directions in iDILI modelling are thoroughly discussed, focusing on the human cellular models available to study the pathophysiological mechanisms of the disease and the most used in vivo animal iDILI models. We also comment about in silico approaches and the increasing relevance of patient-derived cellular models.es_ES
dc.description.sponsorshipThis work was supported by grants of Instituto de Salud Carlos III cofounded by Fondo Europeo de Desarrollo Regional-FEDER (contract numbers: PI18/01804, PI19-00883, PT20/00127, UMA18-FEDERJA-194, PY18-3364, Spain) and grants of Consejería de Salud de Andalucía cofounded by FEDER (contract number: PEMP-0127-2020, Spain). M.V.P. holds a Sara Borrell (CD21/00198, Spain) research contract from ISCIII and Consejería de Salud de Andalucía. C.L.G. holds a Juan de la Cierva Incorporación (IJCI-2017-31466, Spain) research contract from Ministerio de Ciencia del Gobierno de España. SCReN and CIBERehd are funded by ISCIII (Spain). This publication is based upon work from COST Action “CA17112dProspective European Drug-Induced Liver Injury Network” supported by COST (European Cooperation in Science and Technology); www.cost.eu. The figures in this review were created with Biorender.com.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectPatología mitocondriales_ES
dc.subjectHígadoes_ES
dc.subjectEstrés oxidativoes_ES
dc.subjectInmunorrespuestaes_ES
dc.subject.otherDrug-induced liver injuryes_ES
dc.subject.otherPreclinical modelses_ES
dc.subject.otherMechanismses_ES
dc.subject.otherOxidative stresses_ES
dc.subject.otherMitochondrial damagees_ES
dc.subject.otherImmune responsees_ES
dc.subject.otherPersonalized medicinees_ES
dc.titlePreclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards predictiones_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Medicinaes_ES
dc.identifier.doi10.1016/j.apsb.2021.11.013
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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