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      • A revised electronic version of RUCAM for the diagnosis of DILI 

        Hayashi, Paul H.; Lucena-González, María Isabel; Fontana, Robert J.; Bjornsson, Einar S.; Aithal, Guruprasad P.; [et al.] (Wiley, 2022)
        Background and Aims: Roussel Uclaf Causality Assessment Method (RUCAM) for DILI has been hindered by subjectivity and poor reliability. We sought to improve the RUCAM using data from the Drug-Induced Liver Injury Network ...
      • Biomarkers of idiosyncratic drug-induced liver injury (DILI) - a systematic review 

        Atallah, Edmond; Freixo, Cristiana; Alvarez-Alvarez, Ismael; Cubero, Francisco Javier; Gerbes, Alexander L; [et al.] (Taylor & Francis, 2021-11-15)
        Introduction: Idiosyncratic drug-induced liver injury (DILI) is an unpredictable event, and there are no specific biomarkers that can distinguish DILI from alternative explanations or predict its clinical outcomes. Areas ...
      • Clinical characteristics and outcome of drug-induced liver injury in the older patients: from the young-old to the oldest-old 

        Weersink, Rianne A.; Alvarez-Alvarez, Ismael; Medina-Caliz, Inmaculada; Sanabria-Cabrera, Judith; Robles-Diaz, Mercedes; [et al.] (Wiley, 2020-11-11)
        Old patients with hepatotoxicity have been scarcely studied in idiosyncratic drug-induced liver injury (DILI) cohorts. We sought for the distinctive characteristics of DILI in older patients across age groups. A total of ...
      • Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry 

        Stephens, Camilla; Robles-Diaz, Mercedes; Medina-Caliz, Inmaculada; García-Cortés, Miren; Ortega-Alonso, Aida; [et al.] (Elsevier, 2021-02-01)
        Background & aims: Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis of 843 patients with DILI enrolled into ...
      • Critical Review of Gaps in the Diagnosis and Management of Drug-Induced Liver Injury Associated with Severe Cutaneous Adverse Reactions 

        Villanueva-Paz, Marina; Niu, Hao; Segovia-Zafra, Antonio; Medina-Caliz, Inmaculada; Sanabria-Cabrera, Judith; [et al.] (MDPI, 2021-11-15)
        Drug-induced liver injury (DILI) encompasses the unexpected damage that drugs can cause to the liver. DILI may develop in the context of an immunoallergic syndrome with cutaneous manifes- tations, which are sometimes severe ...
      • Drug properties and host factors contribute to biochemical presentation of drug-induced liver injury: a prediction model from a machine learning approach 

        González-Jiménez, Andrés; Suzuki, Ayako; Chen, Minjun; Ashby, Kristin; Alvarez-Alvarez, Ismael; [et al.] (Springer, 2021-03-05)
        Drug-induced liver injury (DILI) presentation varies biochemically and histologically. Certain drugs present quite consistent injury patterns, i.e., DILI signatures. In contrast, others are manifested as broader types of ...
      • Histological and serological features of acute liver injury after SARS-CoV-2 vaccination 

        Codoni, Greta; Kirchner, Theresa; Engel, Bastian; Villamil, Alejandra Maria; Efe, Cumali; [et al.] (Elsevier, 2022)
        Liver injury with autoimmune features after vaccination against Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2) is increasingly reported. We investigated a large international cohort of patients with acute ...
      • Incidence and prevalence of acute hepatitis E virus infection in patients with suspected Drug-Induced Liver Injury in the Spanish DILI Registry 

        Sanabria Cabrera, Judith Adriana; Sanjuán-Jimenéz, Rocío; Clavijo-Frutos, Encarnacion; Medina-Cáliz, Inmaculada; González-Jiménez, Andrés; [et al.] (2020)
        Background and Aims: Drug-induced liver injury (DILI) presents with a wide phenotypic spectrum requiring an extensive differential diagnosis. Hepatitis E virus (HEV) is not systematically ruled out during acute hepatitis ...
      • Lymphocyte Profile and Immune Checkpoint Expression in Drug-Induced Liver Injury: An Immunophenotyping Study 

        Cueto-Sanchez, Alejandro; Niu, Hao; Del Campo-Herrera, Enrique; Robles-Diaz, Mercedes; Sanabria-Cabrera, Judith; [et al.] (Wiley, 2021-09-20)
        The identification of specific HLA risk alleles in drug-induced liver injury (DILI) points toward an important role of the adaptive immune system in DILI development. In this study, we aimed to corroborate the role of an ...
      • Microbiota diversity in nonalcoholic fatty liver disease and in drug-induced liver injury 

        Rodriguez-Diaz, Cristina; Taminiau, Bernard; García-García, Alberto; Cueto, Alejandro; Robles-Díaz, Mercedes; [et al.] (Elsevier, 2022-08)
        The gut microbiota could play a significant role in the progression of nonalcoholic fatty liver disease (NAFLD); however, its relevance in drug-induced liver injury (DILI) remains unexplored. Since the two hepatic disorders ...
      • Neuroprotective Effect of 3′,4′-Dihydroxyphenylglycol in Type-1-like Diabetic Rats—Influence of the Hydroxytyrosol/3′,4′-dihydroxyphenylglycol Ratio 

        Rodríguez Pérez, María Dolores; Pérez de Algaba, Inmaculada; Martín Aurioles, Esther; Ortega-Hombrados, Laura; Verdugo, Cristina; [et al.] (IOAP-MPDI, 2022-03-08)
        The aim of this study was to assess the possible neuroprotective effect of 3′,4′-dihydroxyphenylglycol (DHPG), a polyphenol from extra virgin olive oil (EVOO), in an experimental model of diabetes and whether this effect ...
      • Oxidative Stress in Drug-Induced Liver Injury (DILI): From Mechanisms to Biomarkers for Use in Clinical Practice 

        Villanueva-Paz, Marina; Morán, Laura; Lopez-Alcantara, Nuria; Freixo, Cristiana; Andrade-Bellido, Raul Jesus; [et al.] (MDPI, 2021-03-05)
        Idiosyncratic drug-induced liver injury (DILI) is a type of hepatic injury caused by an uncommon drug adverse reaction that can develop to conditions spanning from asymptomatic liver laboratoryabnormalitiestoacuteliverfa ...
      • Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction 

        Segovia-Zafra, Antonio; Di Zeo-Sánchez, Daniel Enrique; López-Gómez, Carlos; Pérez-Valdés, Zeus; García-Fuentes, Eduardo; [et al.] (Elsevier, 2021-12)
        Idiosyncratic drug-induced liver injury (iDILI) encompasses the unexpected harms that pre- scription and non-prescription drugs, herbal and dietary supplements can cause to the liver. iDILI remains a major public health ...
      • Prevention and management of idiosyncratic drug-induced liver injury: Systematic review and meta-analysis of randomised clinical trials 

        Niu, Hao; Sanabria-Cabrera, Judith; Alvarez-Alvarez, Ismael; Robles-Diaz, Mercedes; Stankeviciute, Simona; [et al.] (Elsevier, 2021-02)
        Conducting randomised clinical trials (RCTs) in idiosyncratic drug-induced liver injury (DILI) is challenging. This systematic review aims to summarise the design and findings of RCTs in the prevention and management of ...
      • Serious liver injury induced by Nimesulide: an international collaboration study reporting 57 cases 

        Bessone, Fernando; Hernandez, Nelia; Mendizabal, Manuel; Ridruejo, Ezequiel; Gualano, Gisela; [et al.] (Springer, 2021-03-24)
        Nimesulide is a non-steroidal anti-inflammatory drug still marketed in many countries. We aim to analyze the clinical phenotype, outcome, and histological features of nimesulide-induced liver injury (nimesulide-DILI). We ...
        REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA
        REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA
         

         

        REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA
        REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA