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dc.contributor.authorMañas Padilla, María del Carmen
dc.contributor.authorGil Rodríguez, Sara
dc.contributor.authorSampedro-Piquero, Patricia
dc.contributor.authorÁvila-Gámiz, Fabiola
dc.contributor.authorRodríguez de Fonseca, Fernándo
dc.contributor.authorSantin-Nuñez, Luis Javier 
dc.contributor.authorCastilla-Ortega, Maria Estela 
dc.date.accessioned2022-03-07T11:58:51Z
dc.date.available2022-03-07T11:58:51Z
dc.date.issued2021
dc.identifier.citationMañas-Padilla, M. C., Gil-Rodríguez, S., Sampedro-Piquero, P., Ávila-Gámiz, F., Rodríguez de Fonseca, F., Santín, L. J., & Castilla-Ortega, E. (2021). Remote memory of drug experiences coexists with cognitive decline and abnormal adult neurogenesis in an animal model of cocaine-altered cognition. Addiction Biology, 26(2). https://doi.org/10.1111/ADB.12886es_ES
dc.identifier.urihttps://hdl.handle.net/10630/23836
dc.descriptionAuthor manuscriptes_ES
dc.description.abstractCocaine addiction is a chronic disorder in which the person loses control over drug use. The past memories of the stimuli associated with the drug are a relevant clinical problem, since they trigger compulsive drug seeking and taking habits. Furthermore, these persistent drug-related memories seemingly coexist with cognitive decline that predicts worse therapeutic output. Here we use a new animal model of cocaine-altered cognition that allowed to observe these events in the same individual and study their relationship. Mice were chronically administered cocaine in a conditioned place preference (CPP) apparatus for 14 days, and control mice received saline. After 28 days of cocaine withdrawal, animals were tested for retrieval of remote drug-associated memory as well as for cognitive performance in a battery of tests, including novel object and place recognition and spatial memory. The cocaine-withdrawn mice showed persistent CPP memory while impaired in the cognitive tasks, displaying deficits in reference memory acquisition and working memory. However, the CPP expression was not associated to the defective cognitive performance, indicating that they were concomitant but independent occurrences. After completion of the experiment, adult hippocampal neurogenesis (AHN) was studied as a relevant neurobiological correlate due to its potential role in both learning and drug addiction. Results suggested a preserved basal AHN in the cocaine-withdrawn mice, but an aberrant learning-induced regulation of these neurons. This paradigm may be useful to investigate maladaptive cognition in drug addiction as well as related therapies.es_ES
dc.description.sponsorshipAuthors M.C.M-P., S. G-R. and F. A-G. hold predoctoral grants from the Spanish Ministry of Science, Innovation and Universities (FPU17/00276 to M.C.M-P.; FPU18/00941 to S.G-R. and PRE2018-085673 to F.A-G.) and from the University of Málaga (Plan Propio 2017 –‘Contratos predoctorales’ to M.C.M-P.). Author F.A-G held a ‘Garantía Juvenil’ research contract from the University of Málaga co-funded by the Regional Government of Andalusia and the European Social Fund. Author P.S-P. holds a ‘Juan de la Cierva- Formación’ grant (FJCI-2015-23925) from MINECO-AEI/FEDER, UE. Author E.C-O. holds a ‘Jóvenes Investigadores’ grant (code: PSI2015-73156-JIN) from MINECO- AEI/FEDER, UE.es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectToxicomaníaes_ES
dc.subjectNeurobiología del desarrolloes_ES
dc.subjectHipocampo (Cerebro)es_ES
dc.subject.otherCocaine addictiones_ES
dc.subject.otherAdult hippocampal neurogenesises_ES
dc.subject.otherCognitive impairmentes_ES
dc.subject.otherConditioned place preferencees_ES
dc.subject.otherObject and place recognition memoryes_ES
dc.subject.otherMorris water mazees_ES
dc.titleRemote memory of drug experiences coexists with cognitive decline and abnormal adult neurogenesis in an animal model of cocaine-altered cognitiones_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Psicologíaes_ES
dc.identifier.doihttps://doi.org/10.1111/ADB.12886
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersiones_ES


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