- RIUMA Principal
- Investigación
- Fisiología Humana, Histología Humana, Anatomía Patológica y Educación Física y Deportiva - (FHEFD)
- Listar Fisiología Humana, Histología Humana, Anatomía Patológica y Educación Física y Deportiva - (FHEFD) por autor
Listar Fisiología Humana, Histología Humana, Anatomía Patológica y Educación Física y Deportiva - (FHEFD) por autor "Pavía-Molina, José"
Mostrando ítems 1-9 de 9
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Antioxidant and neuroprotective actions of IGF-II against glucocorticoid-induced toxicity in dopaminergic neurons.
Claros-Gil, Silvia; Valverde Moreno, Nadia; Zamorano-González, Pablo; Romero-Zerbo, Silvana Yanina; Lara Fernández, Estrella; Boraldi, Federica; Pavía-Molina, José; García-Fernández, María Inmaculada; Gago-Calderón, Belén; Martín-Montañez, Elisa[et al.] (2023)The neurodegenerative Parkinson’s disease (PD) affects 1–3% of the population aged over 65. A wide range of pathways and mechanisms are involved in its pathogenesis, such as oxidative stress, mitochondrial dysfunction, ... -
Efecto neuroprotector de IGF-II en situaciones de estrés neuronal inducido por corticosterona
Aguirre-Gómez, José Ángel; Martinez-Montañez, Elisa; Pavía-Molina, José; Santín-Núñez, Luis Javier; Estivill-Torrús, Guillermo; García-Fernández, María Inmaculada[et al.] (2013-10-02)El daño por estrés en tejido neuronal mediado por la presencia de elevados niveles de corticosterona, se relaciona con la producción de alteraciones en funciones cognitivas. Así, el estrés agudo induce un aumento importante ... -
Graphene derivative scaffolds facilitate in vitro cell survival and maturation of dopaminergic SN4741 cells
Rodríguez-Losada, Noela; Wendelbo, Rune; García-Fernández, María Inmaculada; Pavía-Molina, José; Martinez-Montañez, Elisa; Lara-Muñoz, José Pablo; Arenas, Ernest; Aguirre-Gómez, José Ángel[et al.] (2014-11-26)The emerging carbon nanomaterial Graphene (G), in the form of scaffold structure, has an efficient bioconjugation with common biomolecules and activates cell differentiation of neuronal stem cells, providing a promising ... -
Graphene derivatives as scaffold for ex vivo survival and maturation of dopaminergic SN4741 cells.
Rodríguez-Losada, Noela; Wendelbo, Rune; García-Fernández, María Inmaculada; Pavía-Molina, José; Martín-Montañez, Elisa; Lara-Muñoz, José Pablo; Arenas, Ernest; Aguirre-Gómez, José Ángel[et al.] (2014-09-01)Carbon nanomaterial Graphene (G) can form a three-dimensional porous structure with efficient bioconjugation and cell differentiation properties, providing a promising scaffold for neural regeneration. Aims: To study this ... -
IGF-II as a neuroprotective and neuroplastic factor in an oxidative damage model induced by glucocorticoids
Lara Fernández, Estrella; Valverde, Nadia; De Luque, Vanesa; Boraldi, Federica; Santín-Núñez, Luis Javier; Pavía-Molina, José; Martín-Montañez, Elisa; García-Fernández, María Inmaculada[et al.] (2018-10-11)IGF-II is a pleiotropic hormone widely distributed in the CNS, which triggers its functions by binding to IGF-IR, InsulinR and IGFII / M6P (IGF-IIR) receptors. Recently, it has been proposed that the effects of IGF-II, ... -
IGF-II treatment prevents the oxidative damage derived by MPP+/MPTP administration in a cellular and animal model of Parkinson’s disease.
Zamorano-González, Pablo; Valverde, Nadia; Claros-Gil, Silvia; López-González, Manuel Víctor; Romero-Zerbo, Silvana Yanina; Lara, Estrella; Boraldi, Federica; Pavía-Molina, José; García-Fernández, María Inmaculada; Gago-Calderón, Belén; Martín-Montañez, Elisa[et al.] (2023)El factor de crecimiento de la insulina-II (IGF-II) ha mostrado efectos antioxidantes y neuroprotectores en algunos trastornos neurodegenerativos, como es la Enfermedad de Parkinson (EP). Analizamos el efecto de IGF-II ... -
Insulin-like growth factor II neuroprotective effects against mitochondrial-oxidative and neuronal damage induced by CORT and MPP+ in dopaminergic neurons
Claros-Gil, Silvia; Cabrera García, Pablo; Valverde, Nadia; Romero-Zerbo, Silvana Yanina; Lara, Estrella; López-González, Manuel Víctor; Shumilov, Kirill; Rivera-Ramírez, Alicia; Pavía-Molina, José; Martín-Montañez, Elisa; García-Fernández, María Inmaculada[et al.] (2022-07-12)Aims: Parkinson’s disease (PD) affects 1–3% of the population aged over 65. Stress seems to contribute to PD neuropathology, probably by dysregulation of the hypothalamic–pituitary–adrenal axis. Key factors are oxidative ... -
Papel del receptor S1P sobre el estrés oxidativo mitocondrial en cultivo neuronal
Valverde, Nadia; Lara, Estrella; Gil Cebrián, Antonio Jesús; De Luque, Vanesa; Boraldi, Federica; Pavía-Molina, José; Fernández, Oscar; Martín-Montañez, Elisa; García-Fernández, María Inmaculada[et al.] (2019-06-25)Introducción: Fingolimod, fármaco inmunomodulador, presenta propiedades neuroprotectoras que podrían promover la recuperación de la función cognitiva en enfermedades neurodegenerativas. El estrés oxidativo parece tener un ... -
Role of Insulin-Growth Factor II on mitochondrial recovery in a cellular model of Parkinson's Disease
Valverde, Nadia; Romero-Zerbo, Silvana Yanina; Lara, Estrella; Claros-Gil, Silvia; Pavía-Molina, José; Martín-Montañez, Elisa; García-Fernández, María Inmaculada[et al.] (Journal of Physiology and Biochemistry, 2022-09)Insulin-growth factor II (IGF-II) has shown antioxidant and neuroprotective effects in some neurodegenerative disorders. ROS causes damage to cellular macromolecules affecting several cellular processes and resulting in ...