- RIUMA Principal
- Investigación
- Fisiología Humana, Histología Humana, Anatomía Patológica y Educación Física y Deportiva - (FHEFD)
- Listar Fisiología Humana, Histología Humana, Anatomía Patológica y Educación Física y Deportiva - (FHEFD) por autor
Listar Fisiología Humana, Histología Humana, Anatomía Patológica y Educación Física y Deportiva - (FHEFD) por autor "Díaz-Cabiale, Zaida"
Mostrando ítems 21-40 de 44
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Galanin decreases NPYY1R internalization and β- Arrestin2 recruitment
Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago-Calderón, Belén; Santín-Núñez, Luis Javier; Fuxe, Kjell; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2015-10-05)We have recently described a Galanin receptor 2(GALR2) and Neuropeptide Y Y1 receptor(NPYY1R) interaction at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers. The aim of this work was to study ... -
Galanin interacts with Neuropeptide Y Y1 receptor in the dentate gyrus of the hippocampus through GALR2/NPYY1R heterodimers
Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago-Calderón, Belén; Santín-Núñez, Luis Javier; Fuxe, Kjell; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2016-07-11)We have shown Galanin(GAL) and Neuropeptide Y Y1(NPYY1) interactions at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers in the amygdala. The aim of this work was to analyze GAL/NPYY1R interactions ... -
Galanin n-terminal fragment (1-15) decreases the voluntary alcohol intake in rats
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Castilla-Ortega, María Estela; Gago-Calderón, Belén; Serrano, Antonia; Sturla, Antonella; García-Durán, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida[et al.] (2018-06-28)Galanin (GAL) is involved in drug abuse and addiction including alcohol intake. In this work, we have analysed the role of the N-terminal GAL fragment (1-15) [GAL(1-15)] in voluntary ethanol consumption in rats using the ... -
Galanin N-Terminal fragment (1-15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT in the Forced Swimming Test.
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier; Gago-Calderón, Belén; Parrado-Romero, Concepción; Gomez de Travecedo, Isabel; Narváez-Bueno, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2016-07-27)Galanin and Galanin (1-15) [GAL(1-15)] are implicated in anxiety- and depression related behaviors. Moreover, Galanin modulates 5-HT1A receptor (5-HT1AR) function at autorreceptor and postsynaptic level in the brain. In ... -
Galanin N-Terminal fragment (1-15) induces a stronger effect than Galanin in depression- and anxiety- like related behavioural tests in rats.
Millón-Peñuela, Carmelo; Narváez-Peláez, Manuel; Flores-Burgess, Antonio; Parrado-Romero, Concepción; Puigcerver-Martínez, Araceli; Coveñas, Rafael; Santín-Núñez, Luis Javier; Borroto Escuela, Dasiel Óscar; Fuxe, Kjell; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2014-07-16)Galanin (GAL) and GAL Receptors are implicated in anxiety- and depression- related behaviours. The GAL N-terminal fragment (1-15) [GAL(1-15)] also induces depressant- and anxiogenic- like actions. In this work, we have ... -
Galanin n-terminal fragment (1-15) induces an anxiety- and depressive-like behaviours in the light/dark and tail suspension tests
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo; Narváez-Peláez, Manuel; Santín-Núñez, Luis Javier; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2015-10-21)Galanin N-terminal fragment (1-15) [Gal(1-15)] is involved in mood regulation. We have shown that intracerebroventricular (icv) administration of Gal(1-15) produces a depressive-like behaviour in the forced swim test (FST) ... -
Galanin N-terminal fragment (1−15) reduces alcohol seeking and alcohol relapse in rats: Involvement of mesocorticolimbic system
Cantero-García, Noelia; Flores-Burgess, Antonio; Pineda-Gómez, Juan Pedro; Orio, Laura; Serrano, Antonia; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (Elsevier, 2022-09)Alcohol Use Disorder (AUD) is among the most prevalent mental illnesses, and due to the low efficacy of the current medication, it is essential to find new biological targets that could modulate alcohol consumption. Since ... -
Galanin n-terminal gragment (1-15) modifies the 5-HT1A receptor against [H3]-8-OH-DPAT binding in the dorsal raphe and hippocampus of the rat
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo; Narváez-Peláez, Manuel; Barroto-Escuela, Dasiel; Santín-Núñez, Luis Javier; Gago-Calderón, Belén; Gomez de Travecedo, Isabel; Narváez-Bueno, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2016-09-09)We have described that Galanin N-terminal fragment (1-15) [GAL(1-15)] is associated with depressive effects and also modulates the antidepressant effects induced by the 5-HT1A receptor (5-HT1AR) agonist 8-OH-DPAT. The aim ... -
Galanin receptor 2 modifies neuropeptide Y Y1 receptor internalization and β-Arrestin recruitment
Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago-Calderón, Belén; Santín-Núñez, Luis Javier; Fuxe, Kjell; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2015-10-05)We have recently described a Galanin receptor 2(GALR2) and Neuropeptide Y Y1 receptor(NPYY1R) interaction at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers. The aim of this work was to study ... -
Galanin receptor/neuropeptide y recptor interactions in the central nervous system
Díaz-Cabiale, Zaida; Narváez-Peláez, Manuel; Millón-Peñuela, Carmelo; Borroto Escuela, Dasiel Óscar; Flores-Burgess, Antonio; Santín-Núñez, Luis Javier; Parrado-Romero, Concepción; Puigcerver-Martínez, Araceli; Fuxe, Kjell; Narváez-Bueno, José Ángel[et al.] (2013-11-20)The presence of Galanin and Neuropeptide Y and/or their receptors in many relevant brain regions related to learning and memory, mood, cardiovascular control and food intake implies that Galanin, and Neuropeptide Y may ... -
Galanin(1-15) reverses the impaired long-term memory effect of fluoxetine in the novel object recognition test. Role of 5-HT1A receptor in medial prefrontal cortex
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo; Gago-Calderón, Belén; García-Durán, Laura; Cantero-García, Noelia; Coveñas, Rafael; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida[et al.] (2019-12-16)In this work, we have studied the effects of GAL(1-15) on FLX- mediated effects on the NOR and the OLM, two tasks where FLX treatment impaired long-term memories 24h post-training. Since the mPFC is a core region for the ... -
Galanin/ Neuropeptide Y Y1 receptor interaction at the cellular and receptor level in the amygdala
Narváez-Peláez, Manuel; Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Parrado-Romero, Concepción; Puigcerver-Martínez, Araceli; Borroto Escuela, Dasiel Óscar; Fuxe, Kjell; Díaz-Cabiale, Zaida; Narváez-Bueno, José Ángel[et al.] (2013-11-18)Galanin (GAL) interacts functionally with Neuropeptide Y Y1 receptor (Y1) in the nucleus tractus solitarius and the arcuate nucleus. Since GAL and Y1 participate in mood disorders, the aim of this work was to analyze GAL/Y1 ... -
GALR1/GALR2 Knockdown rats block the Depression and Anxiogenic effects induced by GAL(1-15): The Heterodimer GALR1/GALR2 as a target of GAL(1-15).
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier; Parrado-Romero, Concepción; Narváez-Bueno, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2015-10-06)The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic- like actions. In this work, we have studied the role of GALR2 and GALR1 on the effects of GAL(1-15) in the Forced Swimming Test (FST) ... -
GALR2/NPYY1R heterodimers interact at receptor level in the dentate gyrus of the hippocampus in rats
Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago-Calderón, Belén; Santín-Núñez, Luis Javier; Fuxe, Kjell; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2016-09-26)Previously, we have described Galanin(GAL) and Neuropeptide Y Y1(NPYY1) interactions at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers in the amygdala. The aim of this work was to study GAL/NPYY1R ... -
Immunohistochemical C-FOS expression and autoradiography to study galnin/neuropeptide y Y1 receptor-receptor interactions in the amygdala
Narváez-Peláez, Manuel; Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Santín-Núñez, Luis Javier; Parrado-Romero, Concepción; Puigcerver-Martínez, Araceli; Borroto Escuela, Dasiel Óscar; Fuxe, Kjell; Díaz-Cabiale, Zaida; Narváez-Bueno, José Ángel[et al.] (2013-10-02)We have shown Galanin(GAL)/Neuropeptide Y Y1 receptor(Y1) interactions in the nucleus tractus solitarius and the arcuate nucleus. Since both peptides play an important role in mood disorders, the aim of this work was to ... -
Interacciones entre la Galanina (1-15) y los receptores Serotoninérgicos 5HT1A en el Sistema Nervioso Central: Implicación en la depresión
Millón-Peñuela, Carmelo (Servicio de Publicaciones y Divulgación Científica, 2015)La Galanina (GAL) es un neuropéptido ampliamente distribuido en el Sistema Nervioso Central (SNC), que presenta un fragmento N-terminal de 15 aminoácidos común en todos los mamíferos. La GAL participa en diversas funciones, ... -
New augmentation strategy in depression: Galanin (1-15) enhances the behavioral effects of Fluoxetine in the olfactory bulbectomy rat.
Flores-Burgess, Antonio; Pineda-Gómez, Juan Pedro; Millón-Peñuela, Carmelo; Gago-Calderón, Belén; García-Durán, Laura; Cantero-García, Noelia; Puigcerver-Martínez, Araceli; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida[et al.] (2022-07-12)Major depression is the largest contributor to global disability by years lived with disability. Selective serotonergic reuptake inhibitors, including fluoxetine (FLX), are the most commonly used antidepressant for the ... -
NPYY1 /Galanin 2 heterodimers in the amygdala: a proximity ligation assay study
Narváez-Peláez, Manuel; Millón-Peñuela, Carmelo; Borroto Escuela, Dasiel Óscar; Flores-Burgess, Antonio; Santín-Núñez, Luis Javier; Parrado-Romero, Concepción; Gago-Calderón, Belén; Puigcerver-Martínez, Araceli; Fuxe, Kjell; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2014-07-10)We have shown that Galanin(GAL) interacts with Neuropeptide Y Y1 receptor(Y1) at behavioural, cellular and receptor levels in the Amygdala. Since both peptides play an important role in mood disorders, the aim of this work ... -
Role of the 5-HT1A receptors in the effect of Galanin(1-15) on Fluoxetine-mediated action in the forced swimming test
Flores-Burgess, Antonio; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Narváez-Bueno, José Ángel; Fuxe, Kjell[et al.] (2018-06-28)Galanin N-terminal fragment (1-15) [GAL(1-15)] modulates the antidepressant effects induced by the 5-HT1A receptor (5-HT1AR) agonist in the forced swimming test (FST) and the binding characteristics and mRNA levels of ...