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dc.contributor.authorRodríguez Pérez, María Dolores
dc.contributor.authorPérez de Algaba, Inmaculada
dc.contributor.authorMartín Aurioles, Esther
dc.contributor.authorOrtega-Hombrados, Laura
dc.contributor.authorVerdugo, Cristina
dc.contributor.authorFernández-Prior, María África
dc.contributor.authorBermúdez-Oria, Alejandra
dc.contributor.authorDe-la-Cruz-Cortes, Jose Pedro 
dc.contributor.authorGonzalez-Correa, Jose Antonio 
dc.date.accessioned2022-05-17T10:21:54Z
dc.date.available2022-05-17T10:21:54Z
dc.date.issued2022-03-08
dc.identifier.citationRodríguez-Pérez MD, Pérez de Algaba I, Martín-Aurioles E, Arrebola MM, Ortega-Hombrados L, Verdugo C, Fernández-Prior MÁ, Bermúdez-Oria A, De La Cruz JP, González-Correa JA. Neuroprotective Effect of 3′,4′-Dihydroxyphenylglycol in Type-1-like Diabetic Rats—Influence of the Hydroxytyrosol/3′,4′-dihydroxyphenylglycol Ratio. Nutrients. 2022; 14(6):1146. https://doi.org/10.3390/nu14061146es_ES
dc.identifier.urihttps://hdl.handle.net/10630/24140
dc.description.abstractThe aim of this study was to assess the possible neuroprotective effect of 3′,4′-dihydroxyphenylglycol (DHPG), a polyphenol from extra virgin olive oil (EVOO), in an experimental model of diabetes and whether this effect is modified by the presence of another EVOO polyphenol, hydroxytyrosol (HT). The neuroprotective effect was assessed in a hypoxia–reoxygenation model in brain slices and by quantifying retinal nerve cells. The animals were distributed as follows: (1) normoglycemic rats (NDR), (2) diabetic rats (DR), (3) DR treated with HT (5 mg/kg/day p.o.), (4) DR treated with DHPG (0.5 mg/kg/day), or (5) with 1 mg/kg/day, (6) DR treated with HT plus DHPG 0.5 mg/kg/day, or (7) HT plus 1 mg/kg/day p.o. DHPG. Diabetic animals presented higher levels of oxidative stress variables and lower numbers of neuronal cells in retinal tissue. The administration of DHPG or HT reduced most of the oxidative stress variables and brain lactate dehydrogenase efflux (LDH) as an indirect index of cellular death and also reduced the loss of retinal cells. The association of DHPG+HT in the same proportions, as found in EVOO, improved the neuroprotective and antioxidant effects of both polyphenols.es_ES
dc.description.sponsorshipThis study was supported, in part, by the Consejería de Salud. Junta de Andalucía (Spain), Proyectos de Investigación en Salud [Regional Ministry of Health. Junta de Andalucía (Spain), Health Research Projects] (PI-0129-2017). Partial funding for open access charge: Universidad de Málaga.es_ES
dc.language.isoenges_ES
dc.publisherIOAP-MPDIes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDiabeteses_ES
dc.subject.otherHydroxytyrosoles_ES
dc.subject.other30 ,40 -dihydroxyphenylglycoles_ES
dc.subject.otherExtra virgin olive oil; diabetic neuropathyes_ES
dc.subject.otherDiabetes mellituses_ES
dc.titleNeuroprotective Effect of 3′,4′-Dihydroxyphenylglycol in Type-1-like Diabetic Rats—Influence of the Hydroxytyrosol/3′,4′-dihydroxyphenylglycol Ratioes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Medicinaes_ES
dc.identifier.doihttps://doi.org/10.3390/nu14061146
dc.rights.ccAtribución 4.0 Internacional*


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