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Evaluation of Adipose Tissue Zinc-Alpha 2-Glycoprotein Gene Expression and Its Relationship with Metabolic Status and Bariatric Surgery Outcomes in Patients with Class III Obesity
dc.contributor.author | Martínez-Montoro, José Ignacio | |
dc.contributor.author | Ocaña-Wilhelmi, Luis Tomás | |
dc.contributor.author | Soler Humanes, Rocio | |
dc.contributor.author | Motahari-Rad, Hanieh | |
dc.contributor.author | González-Jiménez, Antonio Javier | |
dc.contributor.author | Rivas-Becerra, José | |
dc.contributor.author | Rodríguez-Muñoz, Alba | |
dc.contributor.author | Moreno-Ruiz, Francisco Javier | |
dc.contributor.author | Tomé, Mónica | |
dc.contributor.author | Rodríguez Capitán, Jorge | |
dc.contributor.author | García-Fuentes, Eduardo | |
dc.contributor.author | Tinahones-Madueño, Francisco José | |
dc.contributor.author | Garrido Sánchez, Lourdes | |
dc.contributor.author | Murri, Mora | |
dc.date.accessioned | 2022-06-28T07:14:35Z | |
dc.date.available | 2022-06-28T07:14:35Z | |
dc.date.issued | 2022-06-25 | |
dc.identifier.citation | Martínez-Montoro JI, Ocaña-Wilhelmi L, Soler-Humanes R, Motahari-Rad H, González-Jiménez A, Rivas-Becerra J, Rodríguez-Muñoz A, Moreno-Ruiz FJ, Tomé M, Rodríguez-Capitán J, García-Fuentes E, Tinahones FJ, Garrido-Sánchez L, Murri M. Evaluation of Adipose Tissue Zinc-Alpha 2-Glycoprotein Gene Expression and Its Relationship with Metabolic Status and Bariatric Surgery Outcomes in Patients with Class III Obesity. Biomedicines. 2022; 10(7):1502. https://doi.org/10.3390/biomedicines10071502 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10630/24506 | |
dc.description.abstract | Zinc-α2 glycoprotein (ZAG) is an adipokine involved in adipocyte metabolism with potential implications in the pathogenesis of metabolic disorders. Our aim was to evaluate the relationship between visceral (VAT) and subcutaneous adipose tissue (SAT) ZAG expression and metabolic parameters in patients with class III obesity, along with the impact of basal ZAG expression on short- and medium-term outcomes related to bariatric surgery. 41 patients with class III obesity who underwent bariatric surgery were included in this study. ZAG gene expression was quantified in SAT and VAT. Patients were classified into two groups according to SAT and VAT ZAG percentile. Anthropometric and biochemical variables were obtained before and 15 days, 45 days, and 1 year after surgery. The lower basal SAT ZAG expression percentile was associated with higher weight and waist circumference, while the lower basal VAT ZAG expression percentile was associated with higher weight, waist circumference, insulin, insulin resistance, and the presence of metabolic syndrome. Basal SAT ZAG expression was inversely related to weight loss at 45 days after surgery, whereas no associations were found between basal VAT ZAG expression and weight loss after surgery. Additionally, a negative association was observed between basal SAT and VAT ZAG expression and the decrease of gamma-glutamyl transferase after bariatric surgery. Therefore, lower SAT and VAT ZAG expression levels were associated with an adverse metabolic profile. However, this fact did not seem to confer worse bariatric surgery-related outcomes. Further research is needed to assess the clinical significance of the role of ZAG expression levels in the dynamics of hepatic enzymes after bariatric surgery | es_ES |
dc.description.sponsorship | This study has been co-funded by FEDER funds (“A way to make Europe”). M.M. and L.G.S. are also supported by UMA18-FEDERJA-285 and UMA20-FEDERJA-144, co-funded by Malaga University, Junta de Andalucía and FEDER funds, CB06/03/0018, PI-0297-2018 and PI-0194-2017, co-funded by FEDER funds and Consejería de Salud y Familias, Junta de Andalucía, and CP17/00133, Instituto de Salud Carlos III (ISCIII), Ministry of Science, Innovation and Universities, Spain Partial funding for open access charge: Universidad de Málaga | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | IOAP-MPDI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Tejido adiposo | es_ES |
dc.subject.other | Adipose tissue | es_ES |
dc.subject.other | Zinc-α2 glycoprotein | es_ES |
dc.subject.other | Gene expression | es_ES |
dc.subject.other | Metabolic syndrome | es_ES |
dc.subject.other | Bariatric surgery | es_ES |
dc.subject.other | Morbid obesity | es_ES |
dc.title | Evaluation of Adipose Tissue Zinc-Alpha 2-Glycoprotein Gene Expression and Its Relationship with Metabolic Status and Bariatric Surgery Outcomes in Patients with Class III Obesity | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.centro | Facultad de Medicina | es_ES |
dc.identifier.doi | https://doi.org/10.3390/biomedicines10071502 | |
dc.rights.cc | Atribución 4.0 Internacional | * |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |