Psicobiología y Metodología de las Ciencias del Comportamiento - (PMCC)
Estas son las colecciones en las que puede catalogar la producción investigadora del departamento Psicobiología y Metodología de las Ciencias del Comportamiento. Si considera que ninguna de estas se ajusta a su material pida una nueva colección en la sección de sugerencias.
Colecciones en esta comunidad
Envíos recientes
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Efectos del estrés sobre comportamientos de tipo depresivo, la microglía y la neurogénesis hipocampal. Papel del sistema LPA endógeno
(UMA Editorial, 2022)El estrés constituye el principal factor ambiental en la etiología de los trastornos psicopatológicos, entre ellos la depresión. El hipocampo es una de las regiones más sensibles a los efectos nocivos del estrés, pudiendo ... -
Reduction of adult neurogenesis by temozolomide inhibits intrinsic preference for exploring complex objects in mice
(2022)Intrinsic exploratory bias is an innate tendency to prefer certain types of stimuli or environments over others. For example, mice would genuinely spent more time exploring perceptually complex objects (i.e. with edges and ... -
Efficacy Of Intensive Tele-Rehabilitation Combined With Donepezil Compared To Face-to-face Administration
(2022)Objectives: (a) To evaluate the benefits promoted by two modalities of intensive language-action therapy, telerehabilitation (Tele-ILAT) and face-to-face (ILAT), applied alone and in combination with Donepezil to persons ... -
Acute psychological stress: effects on hippocampal neurogenesis and the role of microglia
(2022)Among all the factors that can contribute to the onset of psychopathological disorders, stress is the main environmental factor. The hippocampus is one of the most sensitive regions to the harmful effects of stress, in ... -
Effects of sequential exposure to physical exercise and cognitive training on hippocampal neurogenesis in mice
(2022-07-13)AIMS: Physical exercise and cognitive training hippocampal dependent tasks are known to enhance adult hippocampal neurogenesis (AHN). Here we aimed to evaluate the effect of either a moderate-intensity exercise protocol, ... -
Neuroprotective effects of insulin-like growth factor II in a mouse model of Parkinson's disease
(2022-07-20)Progressive degeneration of the nigrostriatal dopaminergic pathway is a core, currently irreversible pathological hallmark of Parkinson’s disease (PD) that leads to a variety of motor and non-motor symptoms. Here, we aimed ... -
Chronic cocaine exposure during adolescence in mice induces alterations in hippocampal neurogenesis and spatial memory
(2022-07)Objectives: Cocaine is the second most widely consumed illicit drug even at early ages, with a prevalence of 2.9% in Spain in the 14-18 age group. Chronic consumption produces several cognitive-behavioral and hippocampal ... -
Influence of neurogenic improvement strategies on extinction and reinstatement of cocaine-induced conditioned place preference
(2022)AIMS: Modulation of adult hippocampal neurogenesis (AHN) has been shown to influence the maintenance of drug-context associations. We aimed to study whether the enhancement of AHN by using a water maze spatial learning ... -
Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders
(IOAP-MPDI, 2022-04-30)Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder ... -
Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex
(IOAP-MPDI, 2022-05-14)(1) Background: Co-occurrence of mental and substance use disorders (SUD) is prevalent, but complicates their clinical courses, and specific biomarkers are required. Amino acids are altered in primary mental disorders; ... -
Life Satisfaction and Character Strenghs in Ecuatorian Adolescents
(Springer, 2021-11-27)There is empirical evidence that life satisfaction (LS) in adolescence is associated with adequate development and future well-being. Research into the factors underpinning LS can therefore help to promote healthier ... -
New Evidence for the Psychometric Properties of the Spanish Version of the Gain in Alzheimer Care Instrument
(Cambridge, 2021-05-07)The aim was to analyze the psychometric properties of the Spanish version of the Gain in Alzheimer Care Instrument (GAIN), providing validity evidence based on its internal structure, reliability, item analysis, and ... -
LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance.
(Neuropharmacology, 2020-03-01)The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. Current data suggest that the ... -
Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models
(ELSEVIER, 2021-11)Stress may have a negative effect on mental health and is the primary environmental risk factor in the aetiology of depression. Nevertheless, the neurobiological mechanisms underlying this mood disorder remain ... -
Chronic central modulation of LPA/LPA receptors-signaling pathway in the mouse brain regulates cognition, emotion, and hippocampal neurogenesis.
(Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2021-06-06)Several studies have demonstrated that lysophosphatidic acid (LPA) acts through its LPA receptors in multiple biological and behavioral processes, including adult hippocampal neurogenesis, hippocampal-dependent memory, and ... -
Training memory without aversion: Appetitive hole-board spatial learning increases adult hippocampal neurogenesis
(Elsevier, 2018)(AHN). However, the vast majority of findings on the learning-induced regulation of AHN derive from aversively-motivated tasks, mainly the water maze paradigm, in which stress is a confounding factor that affects the AHN ... -
Where to place the rewards? Exploration bias in mice influences performance in the classic hole-board spatial memory test
(Springer, 2019)The classic hole-board paradigm (a square arena with 16 holes arranged equidistantly in a 4x4 pattern) assesses both exploration and spatial memory in rodents. For spatial memory training, food rewards are hidden in a fixed ... -
Lysophosphatidic acid-induced increase in adult hippocampal neurogenesis facilitates the forgetting of cocaine-contextual memory
(Wiley, 2019)Erasing memories of cocaine-stimuli associations might have important clinical implications for addiction therapy. Stimulating hippocampal plasticity by enhancing adult hippocampal neurogenesis (AHN) is a promising strategy ... -
Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation
(Elsevier, 2019)Drug addiction is a chronic and relapsing disorder in which repeated drug exposure compromises brain neuroplasticity. Brain areas normally involved in learning and goal- directed behaviors become corrupted, which may lead ... -
Highlighting the role of cognitive and brain reserve in the substance use disorder field
(Bentham Science Publishers, 2019)Background: Cognitive reserve (CR) refers to the ability of an individual to cope with brain pathology remaining free of cognitive symptoms. This protective factor has been related to compensatory and more efficient brain ...