• Absence of LPA1 receptor results in altered pattern of limbic activation after tail suspension test 

      Moreno-Fernández, Román D.; Gomez-Salas, Francisco J.; Pérez-Martín, Margarita; Rosell-Valle, Cristina; Castilla-Ortega, Estela; [et al.] (2016-07-20)
      Stress serves as an adaptive mechanism and helps organisms to cope with life-threatening situations. However, individual vulnerability to stress and dysregulation of this system may precipitate stress-related disorders ...
    • Determinación de las especies de LPA en hipocampo de ratón. Efecto de diferentes protocolos de estrés 

      Tabbai-Amal, Sara (UMA Editorial, 2020)
      El LPA es un lípido bioactivo que está involucrado en la señalización intracelular a través de los seis receptores acoplados a proteínas G (LPA1-6). Entre estos receptores, LPA1 es un fuerte candidato para mediar los efectos ...
    • Role of the LPA1 receptor in mood and emotional regulation 

      Moreno-Fernández, Román D.; Pérez-Martín, Margarita; Rosell-Valle, Cristina; Castilla-Ortega, Estela; Chun, Jerold; [et al.] (2015-09-16)
      Depression is a debilitating psychiatric condition characterized by anhedonia and behavioural despair among others symptoms. Despite the high prevalence and devastating impact of depression, underlying neurobiological ...
    • Social avoidance and altered stress axis in a mouse model of anxious depression 

      Nieto-Quero, Andrea; Gómez-Salas, Francisco Javier; Moreno-Fernández, Román; Rosell-del-Valle, Cristina; Pérez-Martín, Margarita; [et al.] (2018-07-17)
      Prevalence of stress-related disorders, such as depression, is raising in modern societies. Indeed, current neurobiological research aims to elucidate the link between deregulation of the hypothalamic-pituitary-adrenal ...
    • Stress coping behaviour, brain connectivity and LPA1 receptor: similarities and differences between the genetic and the pharmacological approach 

      Moreno-Fernández, Román; Nieto-Quero, Andrea; Gómez-Salas, Francisco Javier; Tabbai-Amal, Sara; García-Fernández, María; [et al.] (2018-07-16)
      LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intercellular signalling molecule. It has been recently proposed that this receptor has a ...
    • Stress, depression and the hippocampus: modulatory effects of continuous LPA treatment 

      Moreno-Fernández, Román; Bacq, Alexandre; Rosell-Valle, Crisitina; Zanoletti, Olivia; Cifuentes, Manuel; [et al.] (2019-06-25)
      The LPA1, one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts may be involved in promoting normal emotional behaviors. Evidence also imply a role for the LPA1 receptor ...
    • The limbic brain under stress: a role for the LPA1 receptor 

      Moreno-Fernández, Román D.; Tabbai, S.; Gómez-Salas, Francisco J.; Pérez-Martín, Margarita; Rosell-Valle, Cristina; [et al.] (UNED, 2017-07)
      Adverse events can impact brain structure and function and are considered primary sources of risk for depression, anxiety, and other psychiatric disorders. In this sense, the neurobiological circuitry in charge of dealing ...