PMCC - Artículos
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Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders
(IOAP-MPDI, 2022-04-30)Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder ... -
Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex
(IOAP-MPDI, 2022-05-14)(1) Background: Co-occurrence of mental and substance use disorders (SUD) is prevalent, but complicates their clinical courses, and specific biomarkers are required. Amino acids are altered in primary mental disorders; ... -
Life Satisfaction and Character Strenghs in Ecuatorian Adolescents
(Springer, 2021-11-27)There is empirical evidence that life satisfaction (LS) in adolescence is associated with adequate development and future well-being. Research into the factors underpinning LS can therefore help to promote healthier ... -
New Evidence for the Psychometric Properties of the Spanish Version of the Gain in Alzheimer Care Instrument
(Cambridge, 2021-05-07)The aim was to analyze the psychometric properties of the Spanish version of the Gain in Alzheimer Care Instrument (GAIN), providing validity evidence based on its internal structure, reliability, item analysis, and ... -
LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance.
(Neuropharmacology, 2020-03-01)The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. Current data suggest that the ... -
Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models
(ELSEVIER, 2021-11)Stress may have a negative effect on mental health and is the primary environmental risk factor in the aetiology of depression. Nevertheless, the neurobiological mechanisms underlying this mood disorder remain ... -
Chronic central modulation of LPA/LPA receptors-signaling pathway in the mouse brain regulates cognition, emotion, and hippocampal neurogenesis.
(Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2021-06-06)Several studies have demonstrated that lysophosphatidic acid (LPA) acts through its LPA receptors in multiple biological and behavioral processes, including adult hippocampal neurogenesis, hippocampal-dependent memory, and ... -
Training memory without aversion: Appetitive hole-board spatial learning increases adult hippocampal neurogenesis
(Elsevier, 2018)(AHN). However, the vast majority of findings on the learning-induced regulation of AHN derive from aversively-motivated tasks, mainly the water maze paradigm, in which stress is a confounding factor that affects the AHN ... -
Where to place the rewards? Exploration bias in mice influences performance in the classic hole-board spatial memory test
(Springer, 2019)The classic hole-board paradigm (a square arena with 16 holes arranged equidistantly in a 4x4 pattern) assesses both exploration and spatial memory in rodents. For spatial memory training, food rewards are hidden in a fixed ... -
Lysophosphatidic acid-induced increase in adult hippocampal neurogenesis facilitates the forgetting of cocaine-contextual memory
(Wiley, 2019)Erasing memories of cocaine-stimuli associations might have important clinical implications for addiction therapy. Stimulating hippocampal plasticity by enhancing adult hippocampal neurogenesis (AHN) is a promising strategy ... -
Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation
(Elsevier, 2019)Drug addiction is a chronic and relapsing disorder in which repeated drug exposure compromises brain neuroplasticity. Brain areas normally involved in learning and goal- directed behaviors become corrupted, which may lead ... -
Highlighting the role of cognitive and brain reserve in the substance use disorder field
(Bentham Science Publishers, 2019)Background: Cognitive reserve (CR) refers to the ability of an individual to cope with brain pathology remaining free of cognitive symptoms. This protective factor has been related to compensatory and more efficient brain ... -
Cognitive reserve mediates the severity of certain neuropsychological deficits related to cocaine use disorder
(Elsevier, 2020-08)The concept of cognitive reserve (CR) is being considered in the field of substance use disorder (SUD) by observing that there are individuals whose brain alterations are not related to the cognitive symptomatology they ... -
Adult hippocampal neurogenesis as a target for cocaine addiction: a review of recent developments
(Elsevier, 2020)Basic research in rodents has shown that adult hippocampal neurogenesis (AHN) plays a key role in neuropsychiatric disorders that compromise hippocampal functioning. The discovery that dependence-inducing drugs regulate ... -
Remote memory of drug experiences coexists with cognitive decline and abnormal adult neurogenesis in an animal model of cocaine-altered cognition
(Wiley, 2021)Cocaine addiction is a chronic disorder in which the person loses control over drug use. The past memories of the stimuli associated with the drug are a relevant clinical problem, since they trigger compulsive drug seeking ... -
Persistent changes in exploration and hyperactivity coexist with cognitive impairment in mice withdrawn from chronic cocaine
(Elsevier, 2021)Repeated cocaine exposure induces lasting neurobehavioral adaptations such as cognitive decline in animal models. However, persistent changes in spontaneous –unconditioned- motor and exploratory responses are scarcely ... -
Life satisfaction and the mediating role of character strengths and gains in informal caregivers
(2021-04-27)Introduction: Being an informal caregiver can have both negative and positive consequences for well-being. Within the framework of he stress process model, few studies have examined values and perceived gains of caregiving ...