PMCC - Artículos
Envíos recientes
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The Role of Social Media as a Resource for Mental Health Care.
(MDPI, 2023-06-10) -
Exploring the nutritional composition and bioactive compounds in different cocoa powders
Razola-Díaz, María del Carmen; Aznar-Ramos, María José; Verardo, Vito; Melgar-Locatelli, Sonia; Castilla-Ortega, María Estela
; Rodríguez-Pérez, Celia[et al.] (MDPI, 2023-03-14)
Cocoa, the main derivative of the seeds of Theobroma cacao L., has been recognized to have several effects on human health including antioxidant and neuro- and cardio-protective effects, among others. These effects have ... -
Temozolomide treatment inhibits spontaneous motivation for exploring a complex object in mice: a potential role of adult hippocampal neurogenesis in ‘curiosity’.
Mañas Padilla, María del Carmen; Melgar-Locatelli, Sonia; Vicente, Lucía; Gil-Rodriguez, Sara; Rivera, Patricia; Rodríguez-Pérez, Celia; Castilla-Ortega, María Estela[et al.] (Wiley, 2022-12-14)
Intrinsic exploratory biases are an innate motivation for exploring certain types of stimuli or environments over others, and they may be associated with cognitive, emotional, and even personality-like traits. However, ... -
Optimal scheduling of ancillary services provided by an electric vehicle aggregator
De-la-Torre-Fazio, Sebastián Bienvenido; Aguado-Sánchez, José Antonio; Sauma, E. (Elsevier, 2022-11-21)
Massification of Electric vehicles (EVs) is becoming a worldwide reality as a means to combat climate change and local pollution. Considering that most of the time vehicles are in parking places, there is an opportunity ... -
Donepezil alone and combined with intensive language-action therapy on depression and apathy in chronic post-stroke aphasia: A feasibility study
Berthier-Torres, Marcelo Luis; Edelkraut, Lisa; López-González, Francisco Javier; López-Barroso, Diana; Mohr, Bettina; Pulvermüller, Friedemann; Starkstein, Sergio E.; Jorge, Ricardo E.; Torres-Prioris, María José; Dávila-Arias, María Guadalupe[et al.] (Elsevier, 2022-12-07)
This study explored the feasibility and effectiveness of a short-term (10-week) intervention trial using Donepezil administered alone and combined with intensive language action therapy (ILAT) for the treatment of apathy ... -
Environmental enrichment alleviates cognitive and psychomotor alterations and increases adult hippocampal neurogenesis in cocaine withdrawn mice
Mañas Padilla, María del Carmen; Tezanos, Patricia; Cintado, Elisa; Vicente, Lucía; Sánchez-Salido, Lourdes; Gil-Rodriguez, Sara; Trejo-Pérez, José Luis; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Wiley, 2022-11-16)
Cocaine is a widely used psychostimulant drug whose repeated exposure induces persistent cognitive/emotional dysregulation, which could be a predictor of relapse in users. However, there is scarce evidence on effective ... -
La respuesta placebo en el consumo de cocaína: una revisión sistemática
Rueda, Estela; Navarro-Humanes, José Francisco (Elsevier, 2022-11-17)
El estudio de la respuesta placebo en la modulación de los efectos de las drogas de abuso está recibiendo un interés creciente. El objetivo de la presente revisión sistemática es examinar la respuesta placebo en el consumo ... -
Patients with Schizophrenia Showed Worse Cognitive Performance than Bipolar and Major Depressive Disorder in a Sample with Comorbid Substance Use Disorders
Marquez-Arrico, Julia E.; Gonzalez-Sanchez, Alvaro; Navarro-Humanes, José Francisco; Penadés, Rafael; Adan-Puig, Ana (IOAP-MPDI, 2022-11-09)
Comorbidity of substance use disorders (SUD) and severe mental illness (SMI) is highly frequent in patients, the most common diagnoses being schizophrenia (SZ), bipolar disorder (BD) and major depressive disorder (MDD). ... -
Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders
(IOAP-MPDI, 2022-04-30)Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder ... -
Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex
(IOAP-MPDI, 2022-05-14)(1) Background: Co-occurrence of mental and substance use disorders (SUD) is prevalent, but complicates their clinical courses, and specific biomarkers are required. Amino acids are altered in primary mental disorders; ... -
Life Satisfaction and Character Strenghs in Ecuatorian Adolescents
Yépez-Tito, Pula A.; Ferragut-Ortiz-Tallo, Marta; Cóndor-Guerrón, Shally; Blanca-Mena, María José (Springer, 2021-11-27)
There is empirical evidence that life satisfaction (LS) in adolescence is associated with adequate development and future well-being. Research into the factors underpinning LS can therefore help to promote healthier ... -
New Evidence for the Psychometric Properties of the Spanish Version of the Gain in Alzheimer Care Instrument
García-Castro, F. Javier; Holgado-Tello, Pablo; Blanca-Mena, María José (Cambridge, 2021-05-07)
The aim was to analyze the psychometric properties of the Spanish version of the Gain in Alzheimer Care Instrument (GAIN), providing validity evidence based on its internal structure, reliability, item analysis, and ... -
LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance.
Moreno-Fernández, R.; Rosell-del-Valle, Cristina; Bacq, Alexandre; Zanoletti, Olivia; Cifuentes-Rueda, Manuel; Pérez-Martín, Margarita; Gavito, A.L.; García-Fernández, María Inmaculada; Estivill-Torrús, Guillermo; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Sandi, Carmen; Pedraza-Benítez, María del Carmen[et al.] (Neuropharmacology, 2020-03-01)
The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. Current data suggest that the ... -
Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models
Nieto-Quero, Andrea; Chaves-Peña, Patricia; Santín-Núñez, Luis Javier; Pérez-Martín, Margarita; Pedraza-Benítez, María del Carmen (ELSEVIER, 2021-11)
Stress may have a negative effect on mental health and is the primary environmental risk factor in the aetiology of depression. Nevertheless, the neurobiological mechanisms underlying this mood disorder remain ... -
Chronic central modulation of LPA/LPA receptors-signaling pathway in the mouse brain regulates cognition, emotion, and hippocampal neurogenesis.
Rosell-del-Valle, Cristina; Pedraza-Benítez, María del Carmen; Manuel, Iván; Moreno-Rodríguez, Marta; Rodríguez-Puertas, Rafael; Castilla-Ortega, María Estela; Caramés-Tejedor, José María; Gómez-Conde, Ana Isabel; Zambrana-Infantes, Emma; Ortega-Pinazo, Jesús; Serrano-Castro, Pedro Jesús; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Estivill-Torrús, Guillermo[et al.] (Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2021-06-06)
Several studies have demonstrated that lysophosphatidic acid (LPA) acts through its LPA receptors in multiple biological and behavioral processes, including adult hippocampal neurogenesis, hippocampal-dependent memory, and ... -
Training memory without aversion: Appetitive hole-board spatial learning increases adult hippocampal neurogenesis
Sampedro-Piquero, Patricia; Moreno-Fernández, Román D.; Mañas Padilla, María del Carmen; Gil Rodríguez, Sara; Gavito, Ana; Pavón, Francisco Javier; Pedraza-Benítez, María del Carmen; García-Fernández, María Inmaculada; Ladrón de Guevara-Miranda, David; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Elsevier, 2018)
(AHN). However, the vast majority of findings on the learning-induced regulation of AHN derive from aversively-motivated tasks, mainly the water maze paradigm, in which stress is a confounding factor that affects the AHN ... -
Where to place the rewards? Exploration bias in mice influences performance in the classic hole-board spatial memory test
Sampedro-Piquero, Patricia; Mañas Padilla, María del Carmen; Ávila-Gámiz, Fabiola; Gil Rodríguez, Sara; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Springer, 2019)
The classic hole-board paradigm (a square arena with 16 holes arranged equidistantly in a 4x4 pattern) assesses both exploration and spatial memory in rodents. For spatial memory training, food rewards are hidden in a fixed ... -
Lysophosphatidic acid-induced increase in adult hippocampal neurogenesis facilitates the forgetting of cocaine-contextual memory
Ladrón de Guevara-Miranda, David; Moreno-Fernández, Román D.; Gil Rodríguez, Sara; Rosell-del-Valle, Cristina; Estivill-Torrús, Guillermo; Serrano, Antonia; Pavón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Wiley, 2019)
Erasing memories of cocaine-stimuli associations might have important clinical implications for addiction therapy. Stimulating hippocampal plasticity by enhancing adult hippocampal neurogenesis (AHN) is a promising strategy ... -
Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation
Sampedro-Piquero, Patricia; Ladrón de Guevara-Miranda, David; Pavón, F.J.; Serrano, A; Suarez, J; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Elsevier, 2019)
Drug addiction is a chronic and relapsing disorder in which repeated drug exposure compromises brain neuroplasticity. Brain areas normally involved in learning and goal- directed behaviors become corrupted, which may lead ... -
Highlighting the role of cognitive and brain reserve in the substance use disorder field
Culuti, D; Ladrón de Guevara-Miranda, David; Castilla-Ortega, María Estela; Santín-Núñez, Luis Javier; Sampedro-Piquero, Patricia (Bentham Science Publishers, 2019)
Background: Cognitive reserve (CR) refers to the ability of an individual to cope with brain pathology remaining free of cognitive symptoms. This protective factor has been related to compensatory and more efficient brain ...