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    • PMCC - Contribuciones a congresos científicos
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    •   RIUMA Principal
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    Influence of neurogenic improvement strategies on extinction and reinstatement of cocaine-induced conditioned place preference

    • Autor
      Mullor-Vigo, Rosa; Ávila-Gámiz, Fabiola; Zambrana-Infantes, Emma; Mañas Padilla, María del Carmen; Gil Rodríguez, Sara; Santin-Nuñez, Luis JavierAutoridad Universidad de Málaga; Ladrón de Guevara-Miranda, David; Santin-Nuñez, Luis JavierAutoridad Universidad de Málaga
    • Fecha
      2022
    • Palabras clave
      Cocaína - Congresos; Reducción de riesgos - Congresos; Psicoterapia - Congresos
    • Resumen
      AIMS: Modulation of adult hippocampal neurogenesis (AHN) has been shown to influence the maintenance of drug-context associations. We aimed to study whether the enhancement of AHN by using a water maze spatial learning task (WM), solely or under conditions of neurogenesis stimulation (forced treadmill exercise), could facilitate extinction and prevent primed reinstatement of cocaine-context associations. METHODS: Adult male C57BL/6J mice (N=37) were trained in the Conditioned Place Preference (CPP) paradigm with ascending doses of cocaine (2, 4, 8, 16 mg/kg/d) and subsequently received bromodeoxyuridine (BrdU) injections to label newborn neurons. Then, experimental groups were submitted to 12 days of scheduled exercise and/or 8 days of spatial training in the WM. Sedentary and/or untrained groups stayed undisturbed in their home cages. When BrdU+ cells reached maturation (~6 weeks-old), all mice were tested for CPP memory retrieval. Finally, animals were submitted to forced CPP extinction and tested for CPP extinction and cocaine-primed reinstatement. RESULTS: Animals submitted either to the scheduled exercise protocol, training in the WM or both strategies combined, required fewer sessions to extinct cocaine-CPP associations than control animals. Furthermore, animals submitted to both environmental strategies showed a reduced reinstatement when compared to sedentary animals. These effects are partially related to the functional integration of the newborn neurons in the hippocampus. CONCLUSIONS: Both environmental strategies, alone and combined, can reduce the long-term persistence of cocaine-context associations, being AHN associated with these beneficial effects.
    • URI
      https://hdl.handle.net/10630/24768
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    Abstract FENS_Ávila Gámiz.pdf (100.6Kb)
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    • PMCC - Contribuciones a congresos científicos

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    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA
    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA