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dc.contributor.authorMullor-Vigo, Rosa
dc.contributor.authorÁvila-Gámiz, Fabiola
dc.contributor.authorZambrana-Infantes, Emma
dc.contributor.authorMañas-Padilla, María del Carmen
dc.contributor.authorGil Rodríguez, Sara
dc.contributor.authorSantín-Núñez, Luis Javier 
dc.contributor.authorLadrón de Guevara-Miranda, David
dc.contributor.authorSantín-Núñez, Luis Javier 
dc.date.accessioned2022-07-25T10:54:21Z
dc.date.available2022-07-25T10:54:21Z
dc.date.created2022
dc.date.issued2022
dc.identifier.urihttps://hdl.handle.net/10630/24768
dc.description.abstractAIMS: Modulation of adult hippocampal neurogenesis (AHN) has been shown to influence the maintenance of drug-context associations. We aimed to study whether the enhancement of AHN by using a water maze spatial learning task (WM), solely or under conditions of neurogenesis stimulation (forced treadmill exercise), could facilitate extinction and prevent primed reinstatement of cocaine-context associations. METHODS: Adult male C57BL/6J mice (N=37) were trained in the Conditioned Place Preference (CPP) paradigm with ascending doses of cocaine (2, 4, 8, 16 mg/kg/d) and subsequently received bromodeoxyuridine (BrdU) injections to label newborn neurons. Then, experimental groups were submitted to 12 days of scheduled exercise and/or 8 days of spatial training in the WM. Sedentary and/or untrained groups stayed undisturbed in their home cages. When BrdU+ cells reached maturation (~6 weeks-old), all mice were tested for CPP memory retrieval. Finally, animals were submitted to forced CPP extinction and tested for CPP extinction and cocaine-primed reinstatement. RESULTS: Animals submitted either to the scheduled exercise protocol, training in the WM or both strategies combined, required fewer sessions to extinct cocaine-CPP associations than control animals. Furthermore, animals submitted to both environmental strategies showed a reduced reinstatement when compared to sedentary animals. These effects are partially related to the functional integration of the newborn neurons in the hippocampus. CONCLUSIONS: Both environmental strategies, alone and combined, can reduce the long-term persistence of cocaine-context associations, being AHN associated with these beneficial effects.es_ES
dc.description.sponsorshipPSI2017-82604; PRE2018-085673; 08-2021-AREA3; B1-2020_06;Posdoc_21_00222; Posdoctoral_a32. I Plan Propio de la Universidad de Málaga. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Teches_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectCocaína - Congresoses_ES
dc.subjectReducción de riesgos - Congresoses_ES
dc.subjectPsicoterapia - Congresoses_ES
dc.subject.otherCocaine addictiones_ES
dc.subject.otherAdult hippocampal neurogenesises_ES
dc.subject.otherConditioned place preferencees_ES
dc.titleInfluence of neurogenic improvement strategies on extinction and reinstatement of cocaine-induced conditioned place preferencees_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Psicología y Logopediaes_ES
dc.relation.eventtitleFENS Forum 2022es_ES
dc.relation.eventplaceParises_ES
dc.relation.eventdate9 de julio de 2022es_ES


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