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Influence of neurogenic improvement strategies on extinction and reinstatement of cocaine-induced conditioned place preference
dc.contributor.author | Mullor-Vigo, Rosa | |
dc.contributor.author | Ávila-Gámiz, Fabiola | |
dc.contributor.author | Zambrana-Infantes, Emma | |
dc.contributor.author | Mañas-Padilla, María del Carmen | |
dc.contributor.author | Gil Rodríguez, Sara | |
dc.contributor.author | Santín-Núñez, Luis Javier | |
dc.contributor.author | Ladrón de Guevara-Miranda, David | |
dc.contributor.author | Santín-Núñez, Luis Javier | |
dc.date.accessioned | 2022-07-25T10:54:21Z | |
dc.date.available | 2022-07-25T10:54:21Z | |
dc.date.created | 2022 | |
dc.date.issued | 2022 | |
dc.identifier.uri | https://hdl.handle.net/10630/24768 | |
dc.description.abstract | AIMS: Modulation of adult hippocampal neurogenesis (AHN) has been shown to influence the maintenance of drug-context associations. We aimed to study whether the enhancement of AHN by using a water maze spatial learning task (WM), solely or under conditions of neurogenesis stimulation (forced treadmill exercise), could facilitate extinction and prevent primed reinstatement of cocaine-context associations. METHODS: Adult male C57BL/6J mice (N=37) were trained in the Conditioned Place Preference (CPP) paradigm with ascending doses of cocaine (2, 4, 8, 16 mg/kg/d) and subsequently received bromodeoxyuridine (BrdU) injections to label newborn neurons. Then, experimental groups were submitted to 12 days of scheduled exercise and/or 8 days of spatial training in the WM. Sedentary and/or untrained groups stayed undisturbed in their home cages. When BrdU+ cells reached maturation (~6 weeks-old), all mice were tested for CPP memory retrieval. Finally, animals were submitted to forced CPP extinction and tested for CPP extinction and cocaine-primed reinstatement. RESULTS: Animals submitted either to the scheduled exercise protocol, training in the WM or both strategies combined, required fewer sessions to extinct cocaine-CPP associations than control animals. Furthermore, animals submitted to both environmental strategies showed a reduced reinstatement when compared to sedentary animals. These effects are partially related to the functional integration of the newborn neurons in the hippocampus. CONCLUSIONS: Both environmental strategies, alone and combined, can reduce the long-term persistence of cocaine-context associations, being AHN associated with these beneficial effects. | es_ES |
dc.description.sponsorship | PSI2017-82604; PRE2018-085673; 08-2021-AREA3; B1-2020_06;Posdoc_21_00222; Posdoctoral_a32. I Plan Propio de la Universidad de Málaga. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Cocaína - Congresos | es_ES |
dc.subject | Reducción de riesgos - Congresos | es_ES |
dc.subject | Psicoterapia - Congresos | es_ES |
dc.subject.other | Cocaine addiction | es_ES |
dc.subject.other | Adult hippocampal neurogenesis | es_ES |
dc.subject.other | Conditioned place preference | es_ES |
dc.title | Influence of neurogenic improvement strategies on extinction and reinstatement of cocaine-induced conditioned place preference | es_ES |
dc.type | info:eu-repo/semantics/conferenceObject | es_ES |
dc.centro | Facultad de Psicología y Logopedia | es_ES |
dc.relation.eventtitle | FENS Forum 2022 | es_ES |
dc.relation.eventplace | Paris | es_ES |
dc.relation.eventdate | 9 de julio de 2022 | es_ES |