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dc.contributor.authorMuñoz-Martín, José
dc.contributor.authorInfantes-López, M. Inmaculada
dc.contributor.authorChaves-Peña, Patricia
dc.contributor.authorNieto-Quero, Andrea
dc.contributor.authorZambrana-Infantes, Emma
dc.contributor.authorPedraza-Benítez, Maria del Carmen 
dc.contributor.authorPérez-Martín, Margarita 
dc.date.accessioned2022-07-26T10:40:51Z
dc.date.available2022-07-26T10:40:51Z
dc.date.issued2022-07
dc.identifier.urihttps://hdl.handle.net/10630/24785
dc.description.abstractIntroduction: Chronic stress is the main environmental factor in the aetiology of depression and it is known that this type of stress may cause alterations in brain regions such as the hippocampus. Nevertheless, changes in a cellular basis are still a subject of study. Objective: The analysis of microglial cells and immature neurons in the dentate gyrus (DG) of stressed mice. Methods: C57BL/6J mice were subjected to Social Defeat Stress model (SDS), consisting of 6 days of social isolation prior to 10 days of stressor. The DG was analysed using immunohistochemistry techniques against Iba1 (microglia) and DCX (immature neurons) following image analysis (ImageJ) to obtain morphological and distribution data of microglial somas. Furthermore, hippocampal neurogenesis was assessed through stereological quantification of DCX+ cells (Visiopharm). Results: An increase in soma size under chronic stress conditions was shown, as well as a less circular and more ameboid soma. These changes were observed mainly in the infrapyramidal blade of the DG. According to microglial cells distribution parameters, the granular cell layer (GCL) was the region which presented the highest microglial density under SDS. Regarding hippocampal neurogenesis, a decrease in the number of DCX+ Type 2-3 cells was observed in the whole DG. Conclusion: All these results o!er a more profound insight of stress changes at a cellular level and could contribute to a better understanding of neurobiological basis in pathologies such as depression. Projects: PSI2017-83408-P (MINECO) and P20 00460 (Consejería de Conocimiento, Investigación y Universidades, Junta de Andalucía).es_ES
dc.description.sponsorshipUniversity of Málaga and the projects PID2020-117464RB-I00 (Ministerio de Ciencia e Innovación, Spain) to Pedraza C. and Pérez-Martin M., PSI2017-83408-P (FEDER/Ministerio de Ciencia, Innovación y Universidades, Spain) to Pedraza C., UMA20- FEDERJA-112 (FEDER/Junta de Andalucía) to Pedraza C. and Pérez-Martin M. and P20-00460 (Consejería de Conocimiento, Investigación y Universidades, Junta de Andalucía) to Pedraza C. Predoctoral Fellowship: FPU16/05308 to Nieto-Quero A. and FPU19/03629 to Infantes-López MI., Ayuda A.2 para Contrato Predoctoral Del I Plan Propio de Investigación, Transferencia y Divulgación Científica de la Universidad de Málaga, Convocatoria 2021 to Munoz-Martin J. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Teches_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectEstrés (Fisiología) - Congresoses_ES
dc.subjectDepresión mental - Efectos del estrés - Congresoses_ES
dc.subjectExperimentación animal - Congresoses_ES
dc.subjectMicroglia - Efectos del estrés - Congresoses_ES
dc.subject.otherChronic stresses_ES
dc.subject.otherMicrogliaes_ES
dc.subject.otherNeurogenesises_ES
dc.subject.otherHippocampuses_ES
dc.subject.otherSocial defeat stresses_ES
dc.subject.otherMicees_ES
dc.titleEffects of chronic stress on hippocampal microglia and neurogenesis of mice under social defeat stress.es_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleFENS-FORUM 2022es_ES
dc.relation.eventplacePARIS, FRANCIAes_ES
dc.relation.eventdate9-13 JULIO 2022es_ES


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