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dc.contributor.authorGonzález-García, Marta
dc.contributor.authorLópez-González, Manuel Víctor 
dc.contributor.authorCarrillo-Franco, Laura
dc.contributor.authorCasermeiro-García, Claudia
dc.contributor.authorDíaz-Casares, Amelia 
dc.contributor.authorDawid-Milner, Marc Stefan 
dc.date.accessioned2022-09-27T10:55:07Z
dc.date.available2022-09-27T10:55:07Z
dc.date.issued2022-09-20
dc.identifier.urihttps://hdl.handle.net/10630/25096
dc.description.abstractThe stimulation of the dorsolateral Periaqueductal Gray matter (dlPAG) produces an increase in sympathetic tone that includes an increase in cardiorespiratory parameters (blood pressure, heart rate and respiratory frequency). PAG and nucleus retroambiguus (nRA) are necessary to produce vocalization. The nRA modifies the activity of laryngeal motoneurons located in the nucleus ambiguus. Rostral and ventral pontine structures involved in cardiorespiratory control, Parabrachial complex (PBc) and A5 Region (A5) are also involved in changes of laryngeal caliber. A high expression of FOXP2 protein, a transcription factor closely related to vocalization, at the level of the PAG, PBc and A5 has been shown. The aim of this study was to characterize the relations between mesencephalic regions (dlPAG) involved in cardiorespiratory control and their possible role in modulating laryngeal activity. Experimental studies were carried out with non-inbred male rats (n=14), SPF, Sprague-Dawley (250-300 g) housed under standard conditions. Animals were anesthetized with sodium pentobarbitone (60 mg/kg i.p., initial dose, supplemented 2 mg/kg, i.v., as necessary). A double tracheal cannulation was carried out. Subglottic pressure was recorded with an aneroid transducer (Hugo Sachs Elektronik D-7801, ± 0,1 psi) by passing a stream of humidified warm medical air with a thermal mass digital air flow meter controller (Bronkhorst Hi-Tec F-201CV-AGD-22-V). Microinjections of PBS-Evans Blue (250 nl, pH 7.4 ± 0.1, 5-s duration) or glutamate (0,25M, 250 nl) were performed within dlPAG. Microinjection of PBS-Evans Blue within dlPAG did not produce any significant cardiorespiratory changes. However, glutamate microinjections within the dlPAG evoked a decrease of laryngeal resistance (p<0,001) accompanied with an increase in respiratory rate (p<0,001) together with a pressor (p<0,001) and tachycardic response (p<0,001).es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectNeuronas motoras - Congresoses_ES
dc.subjectLaringe - Congresoses_ES
dc.subjectExperimentación animal - Congresoses_ES
dc.subject.otherSubglottic Pressurees_ES
dc.subject.otherLaryngeal Motoneuronses_ES
dc.subject.otherdlPAGes_ES
dc.subject.otherNucleus Ambiguuses_ES
dc.titleImpact of Dorsolateral Periaqueductal Grey Matter stimulation in laryngeal activity and subglottic pressure in ratses_ES
dc.typeinfo:eu-repo/semantics/otheres_ES
dc.centroFacultad de Medicinaes_ES
dc.relation.eventtitleXL CONGRESS OF THE SPANISH SOCIETY OF PHYSIOLOGICAL SCIENCESes_ES
dc.relation.eventplaceBADAJOZes_ES
dc.relation.eventdate19/09/2022es_ES


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