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dc.contributor.authorGismero Rodríguez, Javier
dc.contributor.authorLópez-Villodres, Juan Antonio 
dc.contributor.authorEscamilla-Sánchez, Alejandro 
dc.contributor.authorGarcía Díaz, Beatriz
dc.contributor.authorRodríguez-Pérez, Luis Manuel 
dc.contributor.authorMercado-Sáenz, Silvia 
dc.contributor.authorOrtega-Jiménez, María Victoria 
dc.contributor.authorArranz-Salas, Isabel María 
dc.contributor.authorPeláez-González, Alberto Carlos 
dc.contributor.authorBermúdez-Flores, Diego Teófilo 
dc.date.accessioned2022-09-29T09:55:30Z
dc.date.available2022-09-29T09:55:30Z
dc.date.created2022
dc.date.issued2022-09-07
dc.identifier.urihttps://hdl.handle.net/10630/25148
dc.description.abstractIntroduction: Oligodendrocytes (OL) role in demyelinating pathologies such as multiple sclerosis and other neurodegenerative diseases is only recently being subject of extensive research. While the genetic and molecular aspects have been thoroughly studied, their metabolism was overshadowed. In order to develop new therapies to promote remyelination of already damaged axons, we need to accurately describe how OL metabolism affects axon myelination and trophic support (1). The objective of this study is to obtain cytological evidence of the extent of both glycolytic metabolism and oxidative phosphorylation by immunocytochemistry throughout the development of OL. Methods: Oligodendroglia cells from post-natal mice cortices were obtained and cultured. A wide assortment of differentiation-stage-specific cell surface antigens, a glycolytic and an oxidative phosphorylation marker were combined in several immunofluorescences to study both metabolic pathways in each step of differentiation. Results: After analysing them under confocal microscopy and imaging software, we observed a constant upregulation of glycolytic metabolism throughout differentiation, while oxidative phosphorylation seemed to increase with differentiation to then decrease when oligodendrocytes achieved their final maturation stage. Conclusions: Therefore, oxidative phosphorylation may be crucial in the differentiation of precursors and glycolysis would thus be the preferred metabolic pathway for fully matured OL. [1] Rosko L. et al. Neuroscientist. 2019;25(4):334–43.es_ES
dc.description.sponsorshipSupported by UMA and IBIMA and funding from two ongoing projects: - ‘Modulation of oligodendrocyte metabolism via blood vessel remodelling as target to promote remyelination’ (funding by NEURATRIS). - ‘Blood vessel remodelling modulates remyelination by oligodendrocyte metabolic reprogramming’ (funding by Arsep Foundation). Universidad de Málaga. Campus de Excelencia Internacional Andalucía Teches_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectFosforilación - Congresoses_ES
dc.subjectNeuroglia - Congresoses_ES
dc.subjectDesmielinización - Congresoses_ES
dc.subjectSistema nervioso - Degeneración - Congresoses_ES
dc.subject.otherOligodendrocytees_ES
dc.subject.otherGlycolytic metabolismes_ES
dc.subject.otherOxidative phosphorylationes_ES
dc.subject.otherRemyelinationes_ES
dc.subject.otherImmunocytochemistryes_ES
dc.subject.otherOligodendrocyte precursor cellses_ES
dc.titleOligodendrocyte metabolism throughout its differentiation: immunocytochemistry study and its impact in remyelinationes_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Medicinaes_ES
dc.relation.eventtitleXXI CONGRESO DE LA SOCIEDAD ESPAÑOLA DE HISTOLOGÍA E INGENIERÍA TISULARes_ES
dc.relation.eventplaceGRANADAes_ES
dc.relation.eventdate6-9/SEPTIEMBRE/2022es_ES


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