JavaScript is disabled for your browser. Some features of this site may not work without it.

    Listar

    Todo RIUMAComunidades & ColeccionesPor fecha de publicaciónAutoresTítulosMateriasTipo de publicaciónCentrosDepartamentos/InstitutosEditoresEsta colecciónPor fecha de publicaciónAutoresTítulosMateriasTipo de publicaciónCentrosDepartamentos/InstitutosEditores

    Mi cuenta

    AccederRegistro

    Estadísticas

    Ver Estadísticas de uso

    DE INTERÉS

    Datos de investigaciónReglamento de ciencia abierta de la UMAPolítica de RIUMAPolitica de datos de investigación en RIUMAOpen Policy Finder (antes Sherpa-Romeo)Dulcinea
    Preguntas frecuentesManual de usoContacto/Sugerencias
    Ver ítem 
    •   RIUMA Principal
    • Investigación
    • Ponencias, Comunicaciones a congresos y Pósteres
    • Ver ítem
    •   RIUMA Principal
    • Investigación
    • Ponencias, Comunicaciones a congresos y Pósteres
    • Ver ítem

    Ultrastructural evidence of mitochondrial pathology in hippocampal reactive astrocytes of β-amyloidosis Alzheimer’s transgenic mice

    • Autor
      López Oliva, Elba; Trujillo-Estrada, Laura IsabelAutoridad Universidad de Málaga; Sánchez-Mejías, ElisabethAutoridad Universidad de Málaga; Mejías-Ortega, Marina; Fernández-Valenzuela, Juan José; Gómez-Arboledas, Ángela; Dávila-Cansino, José CarlosAutoridad Universidad de Málaga; Vitorica Ferrández, Javier; Gutiérrez-Pérez, AntoniaAutoridad Universidad de Málaga
    • Fecha
      2022
    • Editorial/Editor
      Cold Spring Harbor Laboratory
    • Palabras clave
      Astrocitos; Alzheimer, Enfermedad de; Mitocondrias
    • Resumen
      Astrocytes, the most abundant non-neuronal cell type in the CNS, play essential roles in brain homeostasis and neuroprotection, including metabolic support, synaptic plasticity, cerebral blood flow and immunity. Many of these activities are highly energy demanding and require large energy input from efficient mitochondria. During the pathogenic process of Alzheimer’s disease (AD), amyloid-beta and phospho-tau pathologies have a detrimental effect on neurons and glial cells, also impairing mitochondrial function. This could negatively affect neuronal stability, compromising ATP production and energy metabolism, leading to a deleterious effect promoting neurodegeneration. Though the mitochondrial dysfunction is thought to be an early event in the pathogenesis of AD, the majority of studies have focused on neurons, and little is known about their functional characteristics in astrocytes. We aim to analyze mitochondrial subcellular features of rective astrocytes in APP/PS1 mice hippocampus by transmission electron microscopy and image analysis. Reactive astrocytes cluster around amyloid plaques and display marked morphological changes. Our results show mitochondrial structural alterations including mitochondrial cristae loss, broken double membrane structure and fragmentation. In addition, an increase in both number and size of mitochondria in this transgenic model compared to age-matched WT mice, was found. Since mitochondrial morphology is directly related to mitochondrial fusion/fission, the ultrastructural pathology of astrocytic mitochondria in this amyloidogenic model suggests dynamics abnormalities in these organelles that might lead to astroglial functional deficits compromising neuronal survival. Deciphering the mechanisms underlying this pathological phenomenon might help for the development of therapeutic interventions targeted to protect/improve astrocytic mitochondrial function and, in consequense, enhace their neuroprotective support to neurons in AD.
    • URI
      https://hdl.handle.net/10630/25638
    • Compartir
      RefworksMendeley
    Mostrar el registro completo del ítem
    Ficheros
    Abstract Libro completo Elba.pdf (726.1Kb)
    Colecciones
    • Ponencias, Comunicaciones a congresos y Pósteres

    Estadísticas

    Buscar en Dimension
    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA
    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA
     

     

    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA
    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA