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dc.contributor.authorLoayza-Gutiérrez, Lillyan Teresa
dc.contributor.authorApumayta-Suárez, Eder Valdir
dc.contributor.authorAbdala-Díaz, Roberto Teófilo 
dc.contributor.authorAguilar-Mendoza, Luis Ángel
dc.contributor.authorChávez-Pérez, Jorge Antonio
dc.contributor.authorDecara, Juan
dc.date.accessioned2023-01-25T08:02:17Z
dc.date.available2023-01-25T08:02:17Z
dc.date.issued2022-09-30
dc.identifier.citationLoayza-Gutiérrez, L.T., Apumayta-Suárez, E.V., Abdala, R. et al. Anti-hyperglycemic and antioxidant effect of fucoidan extract from Lessonia trabeculata in alloxan-induced diabetes rats. J Appl Phycol 34, 3247–3261 (2022). https://doi.org/10.1007/s10811-022-02839-3es_ES
dc.identifier.urihttps://hdl.handle.net/10630/25782
dc.description.abstractThe objective of this research was to evaluate a nutritional strategy based on the consumption of a fucoidan extract from brown algae Lessonia trabeculata to control oxidative stress in experimental alloxan-induced insulin-dependent diabetes mellitus rats. Over 30 days, 75, 100, and 125 mg kg−1 of body weight of fucoidan doses were administered and both positive and negative control (n = 5 per group). Serum, liver, pancreas, and kidney biochemical indicators of oxidative stress improvement were evaluated. Measures included lipid peroxidation, superoxide dismutase and catalase activity, and antioxidant activity by assessment of free radical scavenging power and histopathological changes. The results showed an increase in the activity of antioxidant enzymes while reducing oxidative damage (lipid peroxidation index) in serum (p ≤ 0.05) and tissues (p ≤ 0.05). Further, no liver necrosis was observed in treated groups, unlike the Type 1 diabetes positive control group that presented mild necrosis and moderate congestion. In the pancreas, treated rats presented mild oedema, while the positive control group showed moderate oedema. A significant protective effect against oxidative stress caused by alloxan-induced diabetes was found in this model, therefore it can be concluded that fucoidan extracted from the Lessonia trabeculata algae could be considered a good functional compound for the control of oxidative stress in diabetic patients. Because diabetes is such a widespread public health issue, developing fucoidan-based products could be a natural way to improve patients' quality of life.es_ES
dc.description.sponsorshipOpen Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. Funding for open access charge: Universidad de Málaga / CBUA This work was supported by grants from the following institutions: L.T.L-G., E.V.A.S., L.A.A-M. and J.A.C-P. are supported by Project “Desarrollo e Implementación de Procesos Tecnológicos de Validación Analítica y Bioactiva para fucoidano de algas pardas como suplementos nutricionales para humanos”, Convenio N°143-PNICP-PIAP-2015, INNOVATE-PERU. J.D. hold a “Miguel Servet” (CP21/00021) research contract from the Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (ISCIII) co-funded by European Social Fund (ESF), “Investing in your future”, Gobierno de España.es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectReconstruciónes_ES
dc.subject.otherFunctional dataes_ES
dc.subject.otherPartially observed dataes_ES
dc.subject.otherReconstructiones_ES
dc.subject.otherDepth measureses_ES
dc.titleAnti-hyperglycemic and antioxidant effect of fucoidan extract from Lessonia trabeculata in alloxan-induced diabetes ratses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Ciencias Económicas y Empresarialeses_ES
dc.identifier.doi10.1007/s10811-022-02839-3
dc.rights.ccAtribución 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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