Skin lesions are a frequent fact associated with intensive conditions affecting farmed fish.
Knowing that the use of probiotics can improve fish skin health, SpPdp11 dietary administration
has demonstrated beneficial effects for farmed fish, so its potential on the skin needs to be studied
more deeply. The wounded specimens that received the diet with SpPdp11 showed a decrease in
the abundance of Enterobacteriaceae, Photobacterium and Achromobacter related to bacterial biofilm
formation, as well as the overexpression of genes involved in signaling mechanisms (itpr3), cell
migration and differentiation (panxa, ttbk1a, smpd3, vamp5); and repression of genes related to cell
proliferation (vstm4a, areg), consistent with a more efficient skin healing processes than that observed
in the wounded control group. In addition, among the groups of damaged skin with different diets,
Achromobacter, f_Ruminococcaceae, p_Bacteroidetes, Fluviicola and Flavobacterium genera with significant
differences showed positive correlations with genes related to cell migration and negative correlations
with inflammation and cell proliferation and may be the target of future studies.
