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dc.contributor.authorEspinosa García, Elena María
dc.contributor.authorArroyo Varela, Macarena
dc.contributor.authorLarrosa-Jiménez, Rafael 
dc.contributor.authorGómez‑Maldonado, Josefa
dc.contributor.authorCobo Dols, Manuel Ángel
dc.contributor.authorClaros-Díaz, Manuel Gonzalo 
dc.contributor.authorBautista-Moreno, Rocío 
dc.date.accessioned2023-04-19T11:29:33Z
dc.date.available2023-04-19T11:29:33Z
dc.date.created2023-04-19
dc.date.issued2022-10-12
dc.identifier.citationEspinosa Garcia, E., Arroyo Varela, M., Larrosa Jimenez, R., Gomez-Maldonado, J., Cobo Dols, M. A., Claros, M. G., & Bautista Moreno, R. (2023). Construction of miRNA–mRNA networks for the identification of lung cancer biomarkers in liquid biopsies. Clinical and Translational Oncology, 25(3), 643-652.es_ES
dc.identifier.urihttps://hdl.handle.net/10630/26298
dc.description.abstractLung cancer (LC) is the most common cause of cancer death worldwide mostly due to the low survival rate: 75% of cases are identified in advanced stages. In this study, the list of useful biomarkers to make an early diagnosis using liquid biopsies was expanded. A total of 30 samples of LC were analyzed to define potential miRNA biomarkers in liquid biopsies for LC. The biomarkers have been identified in interaction networks miRNA–mRNA. The potential biomarkers have been then validated in large cohorts. A total of 15 candidate miRNAs, that regulate the repression of 30 mRNAs, have been identified as a specific functional interaction network for squamous carcinoma, while the specific functional interaction network of adenocarcinoma consists of four candidate miRNAs that seem to handle the repression of five mRNA. Inspection of expression levels in larger cohorts validates the usefulness of the 11 candidates as biomarkers in liquid biopsies. The 11 candidate miRNAs found could be utilized to form diagnostic predictive biomarkers for LC in liquid biopsies.es_ES
dc.description.sponsorshipOpen Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. Funding for open access charge: Universidad de Málaga / CBUA. This work was funded by the Neumosur grant number 5/2017 and SEPAR grant number 697/2018es_ES
dc.language.isoenges_ES
dc.publisherSpringer Naturees_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectÁcido ribonucleicoes_ES
dc.subjectCáncer -- Investigaciónes_ES
dc.subjectOncologíaes_ES
dc.subject.otherHigh-throughput sequencinges_ES
dc.subject.otherRNA-seq biomarkeres_ES
dc.subject.othermiRNAes_ES
dc.subject.otherLung canceres_ES
dc.titleConstruction of miRNA–mRNA networks for the identification of lung cancer biomarkers in liquid biopsieses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Cienciases_ES
dc.identifier.doihttps://doi.org/10.1007/s12094-022-02969-7
dc.rights.ccAtribución 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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