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dc.contributor.authorDe Ceglia, Marialuisa
dc.contributor.authorMicioni Di Bonaventura, Maria Vittoria
dc.contributor.authorRomano, Adele
dc.contributor.authorFriuli, Marzia
dc.contributor.authorMicioni Di Bonaventura, Emanuela
dc.contributor.authorGavito, Ana L.
dc.contributor.authorBotticelli, Luca
dc.contributor.authorGaetani, Silvana
dc.contributor.authorRodriguez-de-Fonseca, Fernando
dc.contributor.authorCifani, Carlo
dc.date.accessioned2023-04-19T11:45:19Z
dc.date.available2023-04-19T11:45:19Z
dc.date.issued2023
dc.identifier.citationde Ceglia M, Micioni Di Bonaventura MV, Romano A, Friuli M, Micioni Di Bonaventura E, Gavito AL, Botticelli L, Gaetani S, de Fonseca FR, Cifani C. Anxiety associated with palatable food withdrawal is reversed by the selective FAAH inhibitor PF-3845: A regional analysis of the contribution of endocannabinoid signaling machinery. Int J Eat Disord. 2023 Feb 25. doi: 10.1002/eat.23917. Epub ahead of print. PMID: 36840536.es_ES
dc.identifier.urihttps://hdl.handle.net/10630/26299
dc.description.abstractObjective: Consumption of energy-dense palatable "comfort" food can alleviate stress and negative emotions, while abrupt withdrawal from a palatable diet can worsen these symptoms, causing difficulties with adherence to weight-loss diets. Currently, no pharmacological treatment is effective for obesity-related anxiety, so we investigated the endocannabinoid system (ECS), and specifically the fatty acid amide hydrolase (FAAH), as an interesting emerging target in this context because of its key role in the regulation of both energy homeostasis and emotional behavior. Methods: Rats were subjected to exposure and subsequent abstinence from a palatable cafeteria diet. During abstinence period, rats were treated with the selective FAAH inhibitor PF-3845 (10 mg/kg; intraperitoneal administration every other day). Results: Abstinent rats displayed an anxiogenic-like behavior and changes in the proteins of ECS signaling machinery in brain areas involved both in anxiety and food intake regulation. In particular, withdrawal caused a reduction of the expression of cannabinoid receptors in the nucleus accumbens and of enzymes diacylglycerol lipase alpha and monoacylglycerol lipase (MAGL) in the amygdala. Pharmacological inhibition of FAAH exerted an anxiolytic-like effect in abstinent animals and increased both MAGL expression in amygdala and CB2 expression in prefrontal cortex. Discussion: Overall, our results suggest that emotional disturbances associated with dieting are coupled with region-specific alterations in the cerebral expression of the ECS and that the enhancement of the endocannabinoid signaling by FAAH inhibition might represent a novel pharmacological strategy for the treatment of anxiety related to abstinence from palatable food.es_ES
dc.description.sponsorshipFunding for open access charge: Universidad de Málaga / CBUA European Regional DevelopmentFunds-European Union, Grant/Award Number:PI19/01577; Instituto de Salud Carlos III,Grant/Award Number: RETICS; Ministerio deCiencia e Innovaci on, Grant/Award Number:ERDF-EU RD16/0017/0001; Ministerodell'Università e della Ricerca, Grant/AwardNumber: 2012JTX3KL; PNRR-RomeTechnopole-FP7es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectEstrés (fisiología)es_ES
dc.subjectHábitos alimenticios - Aspectos psicológicoses_ES
dc.subject.otherAbstinencees_ES
dc.subject.otherAnxietyes_ES
dc.subject.otherEndocannabinoid systemes_ES
dc.subject.otherFatty acid amide hydrolasees_ES
dc.subject.otherObesityes_ES
dc.subject.otherPalatable dietes_ES
dc.subject.otherPF-3845es_ES
dc.titleAnxiety associated with palatable food withdrawal is reversed by the selective FAAH inhibitor PF-3845: A regional analysis of the contribution of endocannabinoid signaling machineryes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doihttps://doi.org/10.1002/eat.23917
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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