The study of the efects of the magnetic feld (MF) on living matter continues to be a dilemma. Until now, the interaction mechanisms of MF with living matter that explain the observed phenomena are unknown. Despite the existing literature
and the multiple efects described to date, there are few published articles that study the combined efect of MF with other
physical agents during the cellular aging process. In this sense, the aim of this work is to study whether low frequency and
intensity pulsed and sinusoidal MF exposure produce alterations in the cell killing efect of ultraviolet C (UVC) radiation and
thermal shock during the chronological aging of S. cerevisiae. Yeast cells were exposed to 2.45 mT (50 Hz) sinusoidal MF
and 1.5 mT (25 Hz) pulsed MF, during 40 days of aging, in combination with UVC radiation (50 J/m2
) and/or thermal shock
(52°C). Cell survival was evaluated by clonogenic assay. The exposure of yeast to pulsed MF produces an acceleration of
aging, which is not observed in cells exposed to sinusoidal MF. The pulsed MF modifes the cellular response to damaging
agents only in aged S. cerevisiae cells. In this sense, the pulsed MF applied increases the damage induced by UVC radiation
and by thermal shock. In contrast, the sinusoidal MF used has no efect.
