JavaScript is disabled for your browser. Some features of this site may not work without it.

    Listar

    Todo RIUMAComunidades & ColeccionesPor fecha de publicaciónAutoresTítulosMateriasTipo de publicaciónCentrosDepartamentos/InstitutosEditoresEsta colecciónPor fecha de publicaciónAutoresTítulosMateriasTipo de publicaciónCentrosDepartamentos/InstitutosEditores

    Mi cuenta

    AccederRegistro

    Estadísticas

    Ver Estadísticas de uso

    DE INTERÉS

    Datos de investigaciónReglamento de ciencia abierta de la UMAPolítica de RIUMAPolitica de datos de investigación en RIUMAOpen Policy Finder (antes Sherpa-Romeo)Dulcinea
    Preguntas frecuentesManual de usoContacto/Sugerencias
    Ver ítem 
    •   RIUMA Principal
    • Investigación
    • Artículos
    • Ver ítem
    •   RIUMA Principal
    • Investigación
    • Artículos
    • Ver ítem

    Clinical presentation, causative drugs and outcome of patients with autoimmune features in two prospective DILI registries

    • Autor
      García-Cortés, MirenAutoridad Universidad de Málaga; Ortega-Alonso, Aida; Matilla-Cabello, Gonzalo; Medina-Cáliz, InmaculadaAutoridad Universidad de Málaga; Castiella, Agustin; Conde, Isabel; Bonilla-Toyos, Elvira; Pinazo-Bandera, José M.; Hernandez, Nelia; Tagle, Martin; Nunes, Vinicius; Parana, Raymundo; Bessone, Fernando; Kaplowitz, Neil; Lucena-González, María IsabelAutoridad Universidad de Málaga; Álvarez-Álvarez, Ismael; Robles-Díaz, María MercedesAutoridad Universidad de Málaga; Andrade-Bellido, Raúl JesúsAutoridad Universidad de Málaga
    • Fecha
      2023
    • Editorial/Editor
      Wiley
    • Palabras clave
      Hígado - enfermedades; Hepatitis
    • Resumen
      Background & aims: Idiosyncratic drug-induced liver injury (DILI) with autoimmune features is a liver condition with laboratory and histological characteristics similar to those of idiopathic autoimmune hepatitis (AIH), which despite being increasingly re-ported, remains largely undefined. We aimed to describe in-depth the features of this entity in a large series of patients from two prospective DILI registries. Methods: DILI cases with autoimmune features collected in the Spanish DILI Registry and the Latin American DILI Network were compared with DILI patients without autoimmune features and with an independent cohort of patients with AIH. Results: Out of 1,426 patients with DILI, 33 cases with autoimmune features were identified. Female sex was more frequent in AIH patients than in the other groups (p= .001). DILI cases with autoimmune features had significantly longer time to onset (p< .001) and resolution time (p= .004) than those without autoimmune features. Interestingly, DILI patients with autoimmune features who relapsed exhibited significantly higher total bilirubin and transaminases at onset and absence of peripheral eosinophilia than those who did not relapse. The likelihood of relapse increased over time, from 17% at 6 months to 50% 4 years after biochemical normalization. Statins, nitrofurantoin and minocycline were the drugs most frequently associated with this phenotype. Conclusions: DILI with autoimmune features shows different clinical features than DILI patients lacking characteristics of autoimmunity. Higher transaminases and total bilirubin values with no eosinophilia at presentation increase the likelihood of relapse in DILI with autoimmune features. As the tendency to relapse increases over time, these patients will require long-term follow-up.
    • URI
      https://hdl.handle.net/10630/26925
    • DOI
      https://dx.doi.org/https://doi.org/10.1111/liv.15623
    • Compartir
      RefworksMendeley
    Mostrar el registro completo del ítem
    Ficheros
    Liver International - 2023 - Garc a‐Cort s - Clinical presentation causative drugs and outcome of patients with autoimmune.pdf (836.2Kb)
    Colecciones
    • Artículos

    Estadísticas

    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA
    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA
     

     

    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA
    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA