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dc.contributor.authorLópez-Barroso, Diana
dc.contributor.authorParedes-Pacheco, José
dc.contributor.authorTorres-Prioris, María José
dc.contributor.authorDávila-Arias, María Guadalupe 
dc.contributor.authorBerthier-Torres, Marcelo Luis 
dc.date.accessioned2023-06-12T07:06:20Z
dc.date.available2023-06-12T07:06:20Z
dc.date.issued2023
dc.identifier.citationLópez-Barroso, D., Paredes-Pacheco, J., Torres-Prioris, M.J. et al. Brain structural and functional correlates of the heterogenous progression of mixed transcortical aphasia. Brain Struct Funct 228, 1347–1364 (2023). https://doi.org/10.1007/s00429-023-02655-6es_ES
dc.identifier.urihttps://hdl.handle.net/10630/26929
dc.description.abstractMixed transcortical aphasia (MTCA) is characterized by non-fluent speech and comprehension deficits coexisting with preserved repetition. MTCA may evolve to less severe variants of aphasias or even to full language recovery. Mechanistically, MCTA has traditionally been attributed to a disconnection between the spared left perisylvian language network (PSLN) responsible for preserved verbal repetition, and damaged left extrasylvian networks, which are responsible for language production and comprehension impairments. However, despite significant advances in in vivo neuroimaging, the structural and functional status of the PSLN network in MTCA and its evolution has not been investigated. Thus, the aim of the present study is to examine the status of the PSLN, both in terms of its functional activity and structural integrity, in four cases who developed acute post-stroke MTCA and progressed to different types of aphasia. For it, we conducted a neuroimaging- behavioral study performed in the chronic stage of four patients. The behavioral profile of MTCA persisted in one patient, whereas the other three patients progressed to less severe types of aphasias. Neuroimaging findings suggest that preserved verbal repetition in MTCA does not always depend on the optimal status of the PSLN and its dorsal connections. Instead, the right hemisphere or the left ventral pathway may also play a role in supporting verbal repetition. The variability in the clinical evolution of MTCA may be explained by the varying degree of PSLN alteration and individual premorbid neuroanatomical language substrates. This study offers a fresh perspective of MTCA through the lens of modern neuroscience and unveils novel insights into the neural underpinnings of repetition.es_ES
dc.description.sponsorshipFunding for open access publishing: Universidad Málaga/CBUA. This work was supported by the Spanish Ministry of Economy, Industry and Competitiveness, Instituto de Salud Carlos III under Grant: PI16/01514 (MLB and GD) and by the Junta de Andalucía under Grant: P20_00501 (GD). MLB was funded by the European Social Fund (FEDER). DL-B was supported by the Ayuda RYC2020-029495-I Ramón y Cajal funded by the MCIN/AEI/10.13039/501100011033 and by El FSE invierte en tu futuro; and by the Grant PID2021-127617NA-I00 Proyecto de Generación de Conocimiento 2021 funded by MCIN/AEI /10.13039/501100011033/ and FEDER Una manera de hacer Europa. JP-P was funded by a PhD scholarship (FPU16/05198) from the Spanish Ministry of Education, Culture and Sport under the FPU program. MJT-P was supported by a Margarita Salas postdoctoral fellowship by the University of Malaga, funded by the European Union– NextGenerationEU – and the Spanish Ministerio de Universidades, and by a mobility grant from the Spanish Ministry of Universities under the José Castillejo program.es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectNeurologíaes_ES
dc.subjectAfasiaes_ES
dc.subject.otherDTI-tractographyes_ES
dc.subject.otherFunctional magnetic resonance imaginges_ES
dc.subject.otherPerisylvian language networkes_ES
dc.subject.otherPositron emission tomographyes_ES
dc.subject.otherStrokees_ES
dc.subject.otherTranscortical aphasiases_ES
dc.titleBrain structural and functional correlates of the heterogenous progression of mixed transcortical aphasiaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Medicinaes_ES
dc.identifier.doihttps://doi.org/10.1007/s00429-023-02655-6
dc.rights.ccAtribución 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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