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dc.contributor.authorAit El Had, Mustapha
dc.contributor.authorZentar, Houda
dc.contributor.authorRuiz-Muñoz, Blanca
dc.contributor.authorSainz, Juan
dc.contributor.authorGuardia, Juan J.
dc.contributor.authorFernandez, Antonio
dc.contributor.authorJusticia, José
dc.contributor.authorAlvarez-Manzaneda, Enrique
dc.contributor.authorReyes-Zurita, Fernando J.
dc.contributor.authorChahboun, Rachid
dc.date.accessioned2024-01-16T13:47:45Z
dc.date.available2024-01-16T13:47:45Z
dc.date.created2024-01-12
dc.date.issued2023-09-01
dc.identifier.citationHad, M. A. E., Zentar, H., Ruiz-Muñoz, B., Sainz, J., Guardia, J. J., Fernández, A., Justicia, J., Alvarez‐Manzaneda, E., Reyes‐Zurita, F. J., & Chahboun, R. (2023). Evaluation of anticancer and Anti-Inflammatory activities of some synthetic rearranged abietanes. International Journal of Molecular Sciences, 24(17), 13583. https://doi.org/10.3390/ijms241713583es_ES
dc.identifier.urihttps://hdl.handle.net/10630/28793
dc.description.abstractSynthesis of the rearranged abietane diterpenes pygmaeocins C and D, viridoquinone, saprorthoquinone, and 1-deoxyviroxocine has been successfully achieved. The anticancer and anti-inflammatory activities of selected orthoquinonic compounds 5, 7, 13, and 19, as well as pygmaeocin C (17), were evaluated for the first time. The antitumor properties were assessed using three cancer cell lines: HT29 colon cancer cells, Hep G2 hepatocellular carcinoma cells, and B16- F10 murine melanoma cells. Compounds 5 and 13 showed the highest cytotoxicity in HT29 cells (IC50 = 6.69 1.2 g/mL and IC50 = 2.7 0.8 g/mL, respectively). Cytometric studies showed that this growth inhibition involved phase S cell cycle arrest and apoptosis induction, possibly through the activation of the intrinsic apoptotic pathway. Morphological apoptotic changes, including nuclear fragmentation and chromatin condensation, were also observed. Furthermore, the anti-inflammatory activity of these compounds was evaluated on the basis of their ability to inhibit nitric oxide production on the lipopolysaccharide activated RAW 264.7 macrophage cell line. Although all compounds showed high anti-inflammatory activity, with percentages between 40 and 100%, the highest anti-inflammatory potential was obtained by pygmaeocin B (5) (IC50NO = 33.0 0.8 ng/mL). Our results suggest that due to their dual roles, this type of compound could represent a new strategy, contributing to the development of novel anticancer agents.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCáncer - Tratamientoes_ES
dc.subject.otherRearranged abietane typees_ES
dc.subject.otherSemisynthesises_ES
dc.subject.otherAntitumor activityes_ES
dc.subject.otherApoptosises_ES
dc.subject.otherColorectal canceres_ES
dc.subject.otherAnti-inflammatory activityes_ES
dc.subject.otherNitric oxidees_ES
dc.titleEvaluation of anticancer and anti-inflammatory activities of some synthetic rearranged abietaneses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Cienciases_ES
dc.identifier.doihttps://doi.org/10.3390/ijms241713583
dc.rights.ccAtribución 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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