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dc.contributor.authorContreras-Cáceres, Rafael
dc.contributor.authorCabeza, Laura
dc.contributor.authorPerazzoli, Gloria
dc.contributor.authorDíaz-Morilla, Amelia 
dc.contributor.authorLópez-Romero, Juan Manuel 
dc.contributor.authorMelguizo, Consolación
dc.contributor.authorPrados, Jose
dc.date.accessioned2024-02-01T11:21:20Z
dc.date.available2024-02-01T11:21:20Z
dc.date.issued2019-04
dc.identifier.citationContreras-Cáceres R, Cabeza L, Perazzoli G, Díaz A, López-Romero JM, Melguizo C, Prados J. Electrospun Nanofibers: Recent Applications in Drug Delivery and Cancer Therapy. Nanomaterials (Basel). 2019 Apr 24;9(4):656. doi: 10.3390/nano9040656.es_ES
dc.identifier.urihttps://hdl.handle.net/10630/29595
dc.description.abstractPolymeric nanofibers (NFs) have been extensively reported as a biocompatible scaffold to be specifically applied in several researching fields, including biomedical applications. The principal researching lines cover the encapsulation of antitumor drugs for controlled drug delivery applications, scaffolds structures for tissue engineering and regenerative medicine, as well as magnetic or plasmonic hyperthermia to be applied in the reduction of cancer tumors. This makes NFs useful as therapeutic implantable patches or mats to be implemented in numerous biomedical researching fields. In this context, several biocompatible polymers with excellent biocompatibility and biodegradability including poly lactic-co-glycolic acid (PLGA), poly butylcyanoacrylate (PBCA), poly ethylenglycol (PEG), poly (ε-caprolactone) (PCL) or poly lactic acid (PLA) have been widely used for the synthesis of NFs using the electrospun technique. Indeed, other types of polymers with stimuli-responsive capabilities has have recently reported for the fabrication of polymeric NFs scaffolds with relevant biomedical applications. Importantly, colloidal nanoparticles used as nanocarriers and non-biodegradable structures have been also incorporated by electrospinning into polymeric NFs for drug delivery applications and cancer treatments. In this review, we focus on the incorporation of drugs into polymeric NFs for drug delivery and cancer treatment applications. However, the principal novelty compared with previously reported publications is that we also focus on recent investigations concerning new strategies that increase drug delivery and cancer treatments efficiencies, such as the incorporation of colloidal nanoparticles into polymeric NFs, the possibility to fabricate NFs with the capability to respond to external environments, and finally, the synthesis of hybrid polymeric NFs containing carbon nanotubes, magnetic and gold nanoparticles, with magnetic and plasmonic hyperthermia applicability.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectCáncer - Tratamientoes_ES
dc.subjectMedicamentos - Sistemas de administraciónes_ES
dc.subjectMedicamentos poliméricos - Sistemas de administraciónes_ES
dc.subjectNanomedicinaes_ES
dc.subject.otherElectrospun nanofiberses_ES
dc.subject.otherCancer treatmentes_ES
dc.subject.otherDrug releasees_ES
dc.subject.otherNanomedicinees_ES
dc.subject.otherBiocompatible polymerses_ES
dc.subject.otherHyperthermiaes_ES
dc.titleElectrospun nanofibers: recent applications in drug delivery and cancer therapyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.3390/nano9040656
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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