Mostrar el registro sencillo del ítem

dc.contributor.authorMerchante-Berg, Catharina
dc.contributor.authorBrumós, Javier
dc.contributor.authorYun, Jeonga
dc.contributor.authorHu, Qiwen
dc.contributor.authorSpencer, Kristina R
dc.contributor.authorEnríquez, Paul
dc.contributor.authorBinder, Brad M.
dc.contributor.authorHeber, Steffen
dc.contributor.authorStepanova, Anna
dc.contributor.authorAlonso, José M.
dc.date.accessioned2024-02-01T13:44:59Z
dc.date.available2024-02-01T13:44:59Z
dc.date.issued2015-10-22
dc.identifier.citationMerchante C, Brumos J, Yun J, Hu Q, Spencer KR, Enríquez P, Binder BM, Heber S, Stepanova AN, Alonso JM. Gene-specific translation regulation mediated by the hormone-signaling molecule EIN2. Cell. 2015 Oct 22;163(3):684-97. doi: 10.1016/j.cell.2015.09.036. Epub 2015 Oct 22. PMID: 26496608.es_ES
dc.identifier.urihttps://hdl.handle.net/10630/29651
dc.description.abstractThe central role of translation in modulating gene activity has long been recognized, yet the systematic exploration of quantitative changes in translation at a genome-wide scale in response to a specific stimulus has only recently become technically feasible. Using the well-characterized signaling pathway of the phytohormone ethylene and plant-optimized genome-wide ribosome footprinting, we have uncovered a molecular mechanism linking this hormone's perception to the activation of a gene-specific translational control mechanism. Characterization of one of the targets of this translation regulatory machinery, the ethylene signaling component EBF2, indicates that the signaling molecule EIN2 and the nonsense-mediated decay proteins UPFs play a central role in this ethylene-induced translational response. Furthermore, the 3'UTR of EBF2 is sufficient to confer translational regulation and required for the proper activation of ethylene responses. These findings represent a mechanistic paradigm of gene-specific regulation of translation in response to a key growth regulator.es_ES
dc.description.sponsorshipThis work was supported by NSF grants MCB 1158181 and 0519869 to J.M.A.; MCB 0923727 to J.M.A. and A.N.S.; IOS 1444561 to J.M.A., A.N.S., and S.H.; NCSU-RISF to S.H. and J.M.A.; a Marie Curie COFUND U-Mobility post- doctoral fellowship to C.M. (co-funded by the University of Ma´ laga and the EU 7FP GA N 246550); a postdoctoral fellowship from Ministerio de Educacion 2008-2011 to J.B.; and an NSF-REU MCB 06103224 to K.R.S.es_ES
dc.language.isospaes_ES
dc.publisherELSEVIERes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectEtilenoes_ES
dc.subjectHormonas vegetaleses_ES
dc.subject.otherEthylenees_ES
dc.subject.otherEIN2es_ES
dc.subject.otherEBFses_ES
dc.subject.otherTranslationes_ES
dc.subject.other3´UTRes_ES
dc.subject.otherp bodieses_ES
dc.titleGene-specific translation regulation mediated by the hormone-signaling molecule EIN2es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Cienciases_ES
dc.identifier.doi10.1016/j.cell.2015.09.036
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersiones_ES


Ficheros en el ítem

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem