Mostrar el registro sencillo del ítem
Gene-specific translation regulation mediated by the hormone-signaling molecule EIN2
dc.contributor.author | Merchante-Berg, Catharina | |
dc.contributor.author | Brumós, Javier | |
dc.contributor.author | Yun, Jeonga | |
dc.contributor.author | Hu, Qiwen | |
dc.contributor.author | Spencer, Kristina R | |
dc.contributor.author | Enríquez, Paul | |
dc.contributor.author | Binder, Brad M. | |
dc.contributor.author | Heber, Steffen | |
dc.contributor.author | Stepanova, Anna | |
dc.contributor.author | Alonso, José M. | |
dc.date.accessioned | 2024-02-01T13:44:59Z | |
dc.date.available | 2024-02-01T13:44:59Z | |
dc.date.issued | 2015-10-22 | |
dc.identifier.citation | Merchante C, Brumos J, Yun J, Hu Q, Spencer KR, Enríquez P, Binder BM, Heber S, Stepanova AN, Alonso JM. Gene-specific translation regulation mediated by the hormone-signaling molecule EIN2. Cell. 2015 Oct 22;163(3):684-97. doi: 10.1016/j.cell.2015.09.036. Epub 2015 Oct 22. PMID: 26496608. | es_ES |
dc.identifier.uri | https://hdl.handle.net/10630/29651 | |
dc.description.abstract | The central role of translation in modulating gene activity has long been recognized, yet the systematic exploration of quantitative changes in translation at a genome-wide scale in response to a specific stimulus has only recently become technically feasible. Using the well-characterized signaling pathway of the phytohormone ethylene and plant-optimized genome-wide ribosome footprinting, we have uncovered a molecular mechanism linking this hormone's perception to the activation of a gene-specific translational control mechanism. Characterization of one of the targets of this translation regulatory machinery, the ethylene signaling component EBF2, indicates that the signaling molecule EIN2 and the nonsense-mediated decay proteins UPFs play a central role in this ethylene-induced translational response. Furthermore, the 3'UTR of EBF2 is sufficient to confer translational regulation and required for the proper activation of ethylene responses. These findings represent a mechanistic paradigm of gene-specific regulation of translation in response to a key growth regulator. | es_ES |
dc.description.sponsorship | This work was supported by NSF grants MCB 1158181 and 0519869 to J.M.A.; MCB 0923727 to J.M.A. and A.N.S.; IOS 1444561 to J.M.A., A.N.S., and S.H.; NCSU-RISF to S.H. and J.M.A.; a Marie Curie COFUND U-Mobility post- doctoral fellowship to C.M. (co-funded by the University of Ma´ laga and the EU 7FP GA N 246550); a postdoctoral fellowship from Ministerio de Educacion 2008-2011 to J.B.; and an NSF-REU MCB 06103224 to K.R.S. | es_ES |
dc.language.iso | spa | es_ES |
dc.publisher | ELSEVIER | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Etileno | es_ES |
dc.subject | Hormonas vegetales | es_ES |
dc.subject.other | Ethylene | es_ES |
dc.subject.other | EIN2 | es_ES |
dc.subject.other | EBFs | es_ES |
dc.subject.other | Translation | es_ES |
dc.subject.other | 3´UTR | es_ES |
dc.subject.other | p bodies | es_ES |
dc.title | Gene-specific translation regulation mediated by the hormone-signaling molecule EIN2 | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.centro | Facultad de Ciencias | es_ES |
dc.identifier.doi | 10.1016/j.cell.2015.09.036 | |
dc.type.hasVersion | info:eu-repo/semantics/acceptedVersion | es_ES |