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dc.contributor.authorSolé, Ricard V.
dc.contributor.authorValverde, Sergi
dc.contributor.authorRodríguez-Caso, Carlos Francisco 
dc.contributor.authorSardanyés, Josep
dc.date.accessioned2024-02-05T13:21:24Z
dc.date.available2024-02-05T13:21:24Z
dc.date.issued2014-04
dc.identifier.citationSolé, Ricard V., Sergi Valverde, Carlos Rodriguez‐Caso, and Josep Sardanyés. "Can a minimal replicating construct be identified as the embodiment of cancer?." Bioessays 36, no. 5 (2014): 503-512. doi.org/10.1002/bies.201300098es_ES
dc.identifier.urihttps://hdl.handle.net/10630/29836
dc.description.abstractGenomic instability is a hallmark of cancer. Cancer cells that exhibit abnormal chromosomes are characteristic of most advanced tumours, despite the potential threat represented by accumulated genetic damage. Carcinogenesis involves a loss of key components of the genetic and signalling molecular networks; hence some authors have suggested that this is part of a trend of cancer cells to behave as simple, minimal replicators. In this study, we explore this conjecture and suggest that, in the case of cancer, genomic instability has an upper limit that is associated with a minimal cancer cell network. Such a network would include (for a given microenvironment) the basic molecular components that allow cells to replicate and respond to selective pressures. However, it would also exhibit internal fragilities that could be exploited by appropriate therapies targeting the DNA repair machinery. The implications of this hypothesis are discussed.es_ES
dc.description.sponsorshipThis work was supported by a grant MINECO, the Botin Foundation, and the Santa Fe Institutees_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectCarcinogénesis - Aspectos moleculareses_ES
dc.subject.otherCanceres_ES
dc.subject.otherError thresholdes_ES
dc.subject.otherMicrobial populationses_ES
dc.subject.otherMinimal celles_ES
dc.subject.otherMutator phenotypees_ES
dc.titleCan a minimal replicating construct be identified as the embodiment of cancer?es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Cienciases_ES
dc.identifier.doihttps://doi.org/10.1002/bies.201300098
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersiones_ES


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