Mostrar el registro sencillo del ítem

dc.contributor.authorMolina, Noemí
dc.contributor.authorGonzález, Ana
dc.contributor.authorMonopoli, Donato
dc.contributor.authorMentado, Belinda
dc.contributor.authorBecerra-Ratia, José 
dc.contributor.authorSantos-Ruiz, Leonor 
dc.contributor.authorVida-Pol, Yolanda 
dc.contributor.authorPérez-Inestrosa, Ezequiel
dc.date.accessioned2024-02-19T12:40:08Z
dc.date.available2024-02-19T12:40:08Z
dc.date.created2024
dc.date.issued2020-04-01
dc.identifier.citationMolina, N.; González, A.; Monopoli, D.; Mentado, B.; Becerra, J.; Santos-Ruiz, L.; Vida, Y.; Perez-Inestrosa, E. Dendritic Scaffold onto Titanium Implants. A Versatile Strategy Increasing Biocompatibility. Polymers 2020, 12, 770.es_ES
dc.identifier.issn2073-4360
dc.identifier.urihttps://hdl.handle.net/10630/30520
dc.description.abstractOsseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally been solved by coating the former with "organic" ceramics, such as hydroxyapatite. A novel approach is hereby presented, immobilizing covalently dendrimeric structures onto titanium implants. Amide-based amino terminal dendrons were synthetized and coupled to titanium surfaces in a versatile and controlled way. The dendritic moieties provide an excellent scaffold for the covalent immobilization of bioactive molecules, such as extracellular matrix (ECM) protein components or antibiotics. Herein, tripeptide arginine-glycine-aspartic acid (RGD) motifs were used to decorate the dendritic scaffolds and their influence on cell adhesion and proliferation processes was evaluated.es_ES
dc.description.sponsorshipMinisterio de Economía y Competitividad - MINECO (BIO2015-66266-R) Ministerio de Economía y Competitividad - MINECO (CTQ2016-75870-P) Ministerio de Educación, Formación Profesional y Deportes - MECD (FPU15/00641) Junta de Andalucía (PI0250-2016) Junta de Andalucía (PI-0555-2013) Junta de Andalucía (UMA-FEDERJA-007) Junta de Andalucía (PAIDI-FQM-017) Junta de Andalucía (PAIDI-BIO-217) 10% Partial funding for open access charge: Universidad de Málaga / CBUAes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectImplantes artificialeses_ES
dc.subjectCélulas dendríticases_ES
dc.subjectImplantes dentaleses_ES
dc.subjectTitanioes_ES
dc.subjectHuesoses_ES
dc.subject.otherDendritic structureses_ES
dc.subject.otherDental implantses_ES
dc.subject.otherTitanium implantses_ES
dc.subject.otherTripeptide arginine-glycine-aspartic acid (RGD) recognition patternes_ES
dc.subject.otherCell adhesiones_ES
dc.subject.otherCell proliferationes_ES
dc.subject.otherChemical modificationes_ES
dc.subject.otherSurfacees_ES
dc.subject.otherBiomaterialses_ES
dc.subject.otherCell-materials interactiones_ES
dc.subject.otherBonees_ES
dc.subject.otherOsteointegrationes_ES
dc.titleDendritic scaffold onto titanium implants. A versatile strategy increasing biocompatibility.es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Cienciases_ES
dc.identifier.doi10.3390/polym12040770
dc.rights.ccAtribución 4.0 Internacional
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


Ficheros en el ítem

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Atribución 4.0 Internacional
Excepto si se señala otra cosa, la licencia del ítem se describe como Atribución 4.0 Internacional