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Dendritic scaffold onto titanium implants. A versatile strategy increasing biocompatibility.
dc.contributor.author | Molina, Noemí | |
dc.contributor.author | González, Ana | |
dc.contributor.author | Monopoli, Donato | |
dc.contributor.author | Mentado, Belinda | |
dc.contributor.author | Becerra-Ratia, José | |
dc.contributor.author | Santos-Ruiz, Leonor | |
dc.contributor.author | Vida-Pol, Yolanda | |
dc.contributor.author | Pérez-Inestrosa, Ezequiel | |
dc.date.accessioned | 2024-02-19T12:40:08Z | |
dc.date.available | 2024-02-19T12:40:08Z | |
dc.date.created | 2024 | |
dc.date.issued | 2020-04-01 | |
dc.identifier.citation | Molina, N.; González, A.; Monopoli, D.; Mentado, B.; Becerra, J.; Santos-Ruiz, L.; Vida, Y.; Perez-Inestrosa, E. Dendritic Scaffold onto Titanium Implants. A Versatile Strategy Increasing Biocompatibility. Polymers 2020, 12, 770. | es_ES |
dc.identifier.issn | 2073-4360 | |
dc.identifier.uri | https://hdl.handle.net/10630/30520 | |
dc.description.abstract | Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally been solved by coating the former with "organic" ceramics, such as hydroxyapatite. A novel approach is hereby presented, immobilizing covalently dendrimeric structures onto titanium implants. Amide-based amino terminal dendrons were synthetized and coupled to titanium surfaces in a versatile and controlled way. The dendritic moieties provide an excellent scaffold for the covalent immobilization of bioactive molecules, such as extracellular matrix (ECM) protein components or antibiotics. Herein, tripeptide arginine-glycine-aspartic acid (RGD) motifs were used to decorate the dendritic scaffolds and their influence on cell adhesion and proliferation processes was evaluated. | es_ES |
dc.description.sponsorship | Ministerio de Economía y Competitividad - MINECO (BIO2015-66266-R) Ministerio de Economía y Competitividad - MINECO (CTQ2016-75870-P) Ministerio de Educación, Formación Profesional y Deportes - MECD (FPU15/00641) Junta de Andalucía (PI0250-2016) Junta de Andalucía (PI-0555-2013) Junta de Andalucía (UMA-FEDERJA-007) Junta de Andalucía (PAIDI-FQM-017) Junta de Andalucía (PAIDI-BIO-217) 10% Partial funding for open access charge: Universidad de Málaga / CBUA | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Implantes artificiales | es_ES |
dc.subject | Células dendríticas | es_ES |
dc.subject | Implantes dentales | es_ES |
dc.subject | Titanio | es_ES |
dc.subject | Huesos | es_ES |
dc.subject.other | Dendritic structures | es_ES |
dc.subject.other | Dental implants | es_ES |
dc.subject.other | Titanium implants | es_ES |
dc.subject.other | Tripeptide arginine-glycine-aspartic acid (RGD) recognition pattern | es_ES |
dc.subject.other | Cell adhesion | es_ES |
dc.subject.other | Cell proliferation | es_ES |
dc.subject.other | Chemical modification | es_ES |
dc.subject.other | Surface | es_ES |
dc.subject.other | Biomaterials | es_ES |
dc.subject.other | Cell-materials interaction | es_ES |
dc.subject.other | Bone | es_ES |
dc.subject.other | Osteointegration | es_ES |
dc.title | Dendritic scaffold onto titanium implants. A versatile strategy increasing biocompatibility. | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.centro | Facultad de Ciencias | es_ES |
dc.identifier.doi | 10.3390/polym12040770 | |
dc.rights.cc | Atribución 4.0 Internacional | |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |