Secreted autotaxin (ATX) promotes tumor progression by producing the pleiotropic lipid
mediator lysophosphatidic acid
(LPA). In a recent Nature Cancer
paper, Bhattacharyya et al. show
that ATX/LPA signaling suppresses
CCL11-driven infiltration of eosinophils into the pancreatic tumor
microenvironment to facilitate
tumor progression, thus revealing
a new ATX-mediated immune
escape mechanism and highlighting the antitumor potential of
eosinophils
