Cross-border cooperation has been (and still is) one of the main assets of the acquis communitiare in everything that refers to cross-border development. In fact, development initiatives aimed at addressing the problems of intra-European border areas could have better results if they were concerted (horizontally coordinated) and executed jointly by the governments, national, and local actors from both border sides, to improve their populations’ quality of life. The study goal is to provide new contributions that enrich critical reflection and debate on the issue of depopulation, in order to propose economic policy recommendations within a framework of cross-border institutional cooperation and inter- and intra-governmental coordination of political actors involved.