Antisense Oligonucleotides and Magnetic Nanoparticles for Targeted Diagnostic and Cancer Treatment.

Abstract

The resistance of tumors to therapeutic intervention is a major problem in the efficacy of treatments. A recent strategy to overcome this problem proposes the association of antitumor drugs with colloidal nanoparticles. Here a hypothesis is suggested concerning the potential use of antisense Oligo Deoxy Nucleotide (ODN) labeled with iron nanoparticles for tumor antisense gene detection with magnetic resonance gene imaging and cancer treatment.