Multiple sclerosis (MS) is a chronic debilitating disease, in which T-cells are
considered to play a pivotal role.
CD28 is the quintessential costimulatory molecule on T-cells and its expression
declines progressively with repeated stimulations, leading to the generation of
CD28− T-cells. Our aim was to examine whether CD4+CD28- T cells were
enriched in MS patients, and characterize the phenotype of this subset in MS
patients and healthy controls (HC).
All these changes could provide these CD4+CD28- T cell characteristics that
might be involved in the pathogenesis of MS, turning this T-cell subset into a
potential target for future therapeutic strategies.
