AURKA, BIRC5 and PLK1 as potential biomarkers of response in radiation-resistant colorectal cancer

Abstract

The study demonstrated that AURKA, BIRC5 and PLK1 proteins are hyper-expressed in patients affected by colon and rectum adenocarcinoma resistant to radiotherapy. The validation of the expression levels in patient samples shows that they are conserved in tumor stages I-IV, suggesting their potential as possible biomarkers.