Although the advances in LGTBI matter have been many, their pedagogical progress in society is still scarce. More importantly, in terms of gender and identity, the transformations slow down to the point that difference and equality are presented as binomials still under construction. On the other hand, the recent phenomenon of loneliness represents a major challenge for LGBTI societies. In recent years, in Spain, there has been some research developed, and an awareness of this issue has begun to be at the forefront of gerontology studies. However, there are many academic efforts to advance, especially in specific groups such as the situation of transgender older people that is the focus of this chapter.