Listar Artículos por departamento/instituto "Química Orgánica"
Mostrando ítems 1-20 de 51
-
A Turn-On Two-Photon Fluorescent Probe for Detecting Lysosomal Hydroxyl Radicals in Living Cells.
Benítez-Martín, Carlos; Guadix-Domínguez, Juan Antonio
; Pearson, John; Nájera-Albendín, Francisco; Pérez-Pomares, José María; Perez-Inestrosa, Ezequiel[et al.] (Elsevier, 2019)
The detection of reactive oxygen species (ROS) in biological systems and its imaging is of great importance. Among them, the hydroxyl radical (radical dotOH) stands out as one of the most reactive, playing an important ... -
Amoxicillin Haptenation of Alpha-Enolase is Modulated by Active Site Occupancy and Acetylation.
Vida-Pol, Yolanda; Pérez-Inestrosa, Ezequiel; González Morena, Juan Manuel; Sanchez Gomez, Francisco J; Salas, María; Montañez-Vega, María Isabel; Altomare, Alessandra; Aldini, Giancarlo; Pajares, Maria Angeles; Pérez-Sala, Dolores[et al.] (Frontiers, 2022)
Allergic reactions to antibiotics are a major concern in the clinic. ß-lactam antibiotics are the class most frequently reported to cause hypersensitivity reactions. One of the mechanisms involved in this outcome is the ... -
An array of bengamide E analogues modified at the terminal olefinic position: Synthesis and antimor properties.
Martín-Gálvez, Francisca; García-Ruiz, Cristina; Sánchez-Ruiz, Antonio; Valeriote, Frederick A.; Sarabia-García, Francisco Ramón (Chemistry Europe · European Chemical Societies Publishing, 2013-03-19)
Based on our previously described synthetic strategy for bengamide E, a natural product of marine origin with antitumor activity, a small library of analogues modified at the terminal olefinic position was generated with ... -
An olefin cross-metathesis approach to depudecin and stereoisomeric analogues
Cheng-Sánchez, Iván; García-Ruiz, Cristina; Guerrero Vásquez, Guillermo A.; Sarabia-García, Francisco Ramón (ACS, 2017)
A new total synthesis of the natural product (−)-depudecin, a unique and unexplored histone deacetylase (HDAC) inhibitor, is reported. A key feature of the synthesis is the utilization of an olefin cross-metathesis strategy, ... -
An olefin metathesis approach towards the solomonamides.
Cheng-Sánchez, Iván; García-Ruiz, Cristina; Sarabia-García, Francisco Ramón (Elsevier, 2016)
A new synthetic strategy directed towards the solomonamides, a novel class of cyclopeptides of marine origin, has been developed utilizing an olefin metathesis reaction to form the [15]-membered ring contained in these ... -
Bengamide Analogues Show a Potent Antitumor Activity against Colon Cancer Cells: A Preliminary Study
García-Pinel, Beatriz; Porras Alcalá, Cristina; Cabeza, Laura; Ortiz, Raul; Prados, José; Melguizo, Consolación; Cheng-Sánchez, Iván; López-Romero, Juan Manuel; Sarabia-García, Francisco Ramón[et al.] (2020-05-02)
The limited success and side effects of the current chemotherapeutic strategies against colorectal cancer (CRC), the third most common cancer worldwide, demand an assay with new drugs. The prominent antitumor activities ... -
Benzotriazole-based multidonor-acceptor systems as attractive two-photon absorption dye platforms
Benítez-Martín, Carlos; Donoso, Beatriz; Torres-Moya, Ivan; Herrera-Imbroda, Jesús; Díaz-Ortiz, Ángel; Nájera-Albendín, Francisco; Prieto, Pilar; Pérez-de-Inestrosa-Villatoro, Ezequiel[et al.] (Elsevier, 2022-02-03)
Pyrazine-decorated benzotriazole cores allow the orthogonal combination of two dipolar systems within a single molecule. A series of this type of derivatives was synthesized and their photophysical features were studied. ... -
Catalyzed Methods to Synthesize Pyrimidine and Related Heterocyclic Compounds
Díaz-Fernández, Marcos; Calvo-Losada, Saturnino; Quirante-Sánchez, José Joaquín; Sarabia-García, Francisco Ramón; Algarra-González, Manuel; Pino-González, María Soledad[et al.] (MDPI, 2023-01-12)
This review covers articles published in the period from 2010 to mid-2022 on synthetic advances in the formation of pyrimidine and related heterocyclic compounds. Special emphasis has been given to the different types ... -
Chemistry and biology of bengamides and bengazoles, bioactive natural products from Jaspis sponges
García-Ruiz, Cristina; Sarabia-García, Francisco Ramón (MDPI, 2014)
Sponges corresponding to the Jaspidae family have proved to be a prolific source of bioactive natural products. Among these, the bengamides and the bengazoles stand out by virtue of their unprecedented molecular architectures ... -
Diastereoselective C-alkylation of aldimines, derived from chiral alpha-carbon heteroatom substituted aldehydes, with triethylborane. Application to the synthesis of benzylisoquinolines
Fuentes-Ríos, David; Muñoz, Carmen; Díaz-Morilla, Amelia; Sarabia-García, Francisco Ramón; López-Romero, Juan Manuel (Royal Society of Chemistry, 2023-03-13)
The one-pot reaction of a chiral aldehyde, p-methoxyaniline or p-fluoroaniline, and triethylborane produces the corresponding alkylated chiral amine with high yields and distereoisomeric ratios. Stereocontrol is induced ... -
Dual Nickel/Photoredox-Catalyzed Asymmetric Carbosulfonylation of Alkenes
(ACS, 2023-05-30)An asymmetric three-component carbosulfonylation of alkenes is presented here. The reaction, involving the simultaneous formation of a C–C and a C–S bond across the π-system, uses a dual nickel/photoredox catalytic system ... -
Dynamic Covalent Properties of a Novel Indolo[3,2-b]carbazole Diradical
Badía-Domínguez, Irene; Peña-Álvarez, Miriam; Wang, Deliang; Pérez Guardiola, Andrés; Vida-Pol, Yolanda; Rodríguez-González, Sandra; López Navarrete, Juan T.; Hernández-Jolín, Víctor; Sancho-García, Juan C.; García-Baonza, Valentín; Nash, Rosie; Hartl, František; Li, Hongxiang; Ruiz-Delgado, María del Carmen[et al.] (Wiley, 2021)
This work describes the synthesis and properties of a dicyanomethylene-substituted indolo[3,2-b]carbazole diradical ICz-CN. This quinoidal system dimerises almost completely to (ICz-CN)2, which contains two long C(sp3)−C(sp3) ... -
Electrospun nanofibers: recent applications in drug delivery and cancer therapy
Contreras-Cáceres, Rafael; Cabeza, Laura; Perazzoli, Gloria; Díaz-Morilla, Amelia; López-Romero, Juan Manuel; Melguizo, Consolación; Prados, Jose[et al.] (MDPI, 2019-04)
Polymeric nanofibers (NFs) have been extensively reported as a biocompatible scaffold to be specifically applied in several researching fields, including biomedical applications. The principal researching lines cover the ... -
Energy-Transfer Sensitization of BODIPY Fluorescence in a Dyad with a Two-Photon Absorbing Antenna Chromophore
Dominguez-Alfaro, Antonio; Pais, Vania; Guzmán-Ríos, David; Collado-Martín, Daniel; Nájera-Albendín, Francisco; Perez-Inestrosa, Ezequiel; Pischel, Uve[et al.] (Elsevier, 2023)
A bichromophoric dyad composed of a Prodan-derived moiety and a BODIPY dye was prepared, photophysically characterized, and tested for multiphoton fluorescence microscopy of N13 microglial cells. The dyad shows highly ... -
Epi-, epoxy- and C2-modified bengamides: Synthesis and biological Evaluation
Sarabia-García, Francisco Ramón; Martín-Gálvez, Francisca; García-Ruiz, Cristina; Sánchez-Ruiz, Antonio; Vivar García, Carlos (ACS, 2013)
With the objective of investigating the influence of structural modifications of the polyketide chain of the bengamides upon their antitumoral activities, we targeted the preparation of bengamide E analogues with modification ... -
Evaluation of anticancer and anti-inflammatory activities of some synthetic rearranged abietanes
(MDPI, 2023-09-01)Synthesis of the rearranged abietane diterpenes pygmaeocins C and D, viridoquinone, saprorthoquinone, and 1-deoxyviroxocine has been successfully achieved. The anticancer and anti-inflammatory activities of selected ... -
Exploring the Antiangiogenic Potential of Solomonamide A Bioactive Precursors: In Vitro and In Vivo Evidences of the Inhibitory Activity of Solo F-OH During Angiogenesis
Carrillo, Paloma; Martínez-Póveda, Beatriz Amparo; Cheng-Sánchez, Iván; Guerra, Jessica; Tobia, Chiara; López-Romero, Juan Manuel; Sarabia-García, Francisco Ramón; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María[et al.] (2019-04-15)
Marine sponges are a prolific source of bioactive compounds. In this work, the putative antiangiogenic potential of a series of synthetic precursors of Solomonamide A, a cyclic peptide isolated from a marine sponge, was ... -
Exploring the chemistry of epoxy amides for the synthesis of the 2"-epi-diazepanone core of liposidomycins and caprazamycins
Sarabia-García, Francisco Ramón; Vivar García, Carlos; García-Ruiz, Cristina; Martín Ortiz, Laura; Romero-Carrasco, Antonio (ACS, 2012)
New synthetic strategies have been explored for the synthesis of the structural core of liposidomycins and caprazamycins, an intriguing class of complex nucleoside-type antibiotics. This structural core is comprised of a ... -
Exploring the reactivity of chiral glycidic amides for their applications in synthesis of bioactive compounds.
Sarabia-García, Francisco Ramón; Vivar García, Carlos; García-Ruiz, Cristina; Sánchez-Ruiz, Antonio; Pino-González, María Soledad; García-Castro, Miguel; Chammaa, Samy[et al.] (Wiley, 2014-05)
A new class of chiral sulfonium salts, derived from L- and D-methionine, has been designed and successfully employed in our laboratories for the diastereoselective synthesis of glycidic amides. The epoxy amides obtained ... -
Extended Alkenyl and Alkynyl Benzotriazoles with enhanced Two‐Photon Absorption properties as a promising alternative to Benzothiadiazoles
Torres-Moya, Ivan; Benítez-Martín, Carlos; Donoso, Beatriz; Tardio, Carlos; Martin, Raul; Carrillo, Jose Ramon; Diaz-Ortiz, Angel; Nájera-Albendín, Francisco; Prieto, Pilar; Perez-Inestrosa, Ezequiel[et al.] (Wiley-VCH Verlag GmbH & Co, 2019)
A series of donor–p–acceptor–p–donor (D-p-A-p-D) benzoazole dyes with 2H-benzo[d][1,2,3]triazole or BTDcores have been prepared and their photophysical proper-ties characterized. The properties of these compounds dis-play ...