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    Etiology of tricuspid regurgitation and mortality: a multicenter cohort study

    • Autor
      Rodríguez Capitán, Jorge; Márquez‑Camas, Paloma; Carmona‑Carmona, Jesús; Arroyo Moñino, Diego Félix; Chaparro‑Muñoz, Marinela; Soler‑González, Matías; García del Río, Manuel; Egido de la Iglesia, Teodora; Segovia‑Reyes, Jorge; Murri, Mora; López Salguero, José Raúl; Couto‑Mallón, David; Romero‑Cuevas, Miguel; Pavón-Morón, Francisco Javier; Gutiérrez-Bedmar, MarioAutoridad Universidad de Málaga; Jiménez‑Navarro, ManuelAutoridad Universidad de Málaga
    • Fecha
      2025
    • Editorial/Editor
      Springer Nature
    • Palabras clave
      Cardiología; Válvula tricúspide; Pronóstico médico
    • Resumen
      Background Significant tricuspid regurgitation (TR) encompasses a wide range of etiologies, complicating a comprehensive understanding of disease progression and prognostic factors. This study aimed to assess mortality associated with significant TR, focusing on the role of valvular disease etiology and other predictive factors. Methods This is a retrospective, multicenter, cohort observational study, including all consecutive patients with moderate-to-severe or greater TR. The patients were classified into five etiological groups: organic TR, TR secondary to left valvu-lopathy, TR secondary to left or right ventricular dysfunction, TR secondary to pulmonary hypertension, and atrial TR. The long-term mortality was assessed (median follow-up: 39.8 months). Results 757 patients were included. The overall mortality incidence rate was 162.5 deaths per 1000 patient-years. Compared to atrial TR, all other etiologies presented a higher mortality risk: organic TR adjusted hazard ratio (aHR) = 2.344 (95% confidence interval [CI]: 1.138–4.829), left valvulopathy-related TR aHR = 1.901 (95% CI: 1.011–3.574), ventricular dysfunction-related TR aHR = 3.683 (95% CI: 1.627–8.338), and pulmonary hypertension-related TR aHR = 2.446 (95% CI: 1.215–4.927). In addition to known factors, male sex was associated with a higher mortality risk (aHR = 1.608, 1.175–2.201), while beta-blocker use was linked to a lower risk (aHR = 0.674, 0.502–0.904). Conclusions In a large cohort of patients with significant TR, and after adjusting for clinical and echocardiographic variables, all etiological groups exhibited a higher mortality risk compared to atrial TR. Additionally, male patients with TR had a higher mortality risk, while beta-blocker therapy emerged as a protective factor.
    • URI
      https://hdl.handle.net/10630/38607
    • DOI
      https://dx.doi.org/10.1007/s00392-025-02662-z
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    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA
    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA
     

     

    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA
    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA