Envíos recientes

  • Impact of white adipose tissue in AD pathology 

    Bettinetti-Luque, Miriam; Trujillo-Estrada, Laura; Andreo-Lopez, Juana; Cantero-Molina, Francisco; Rodriguez-Ortiz, Carlos J; [et al.] (2022)
    Aims: Alzheimer’s disease (AD) is a complex disorder and multiple cellular and molecular mechanisms are involved in AD onset and progression. Recent evidences has suggested that metabolic alterations are an important ...
  • Human amyloid seeds aggregate more efficient than seeds from old 3xtg-ad mice 

    Andreo-Lopez, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Huynh, Kelly; Thu Nguyen, Marie Minh; [et al.] (2022)
    Aims: Most age-associated neurodegenerative disorders involve the aggregation of specific proteins within the nervous system, as occurs in Alzheimer’s disease (AD). Recent evidence indicates that Aβ can misfold and aggregate ...
  • Human pluripotent stem cell-derived astrocytes from alzheimer´s disease patients for disease modeling 

    Cáceres Palomo, Laura; López Oliva, Elba; Davila, Jose Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia; [et al.] (2022)
    Aims: The lack of reliable models of Alzheimer´s disease (AD) has impeded the development of effective therapies. Glial cells have a key role in AD pathology, but this cannot be properly modeled using available animal ...
  • Tau pathology and astroglial reactivity: a comparative study of two mouse models of tauopathy 

    Fernandez-Valenzuela, Juan José; López Oliva, Elba; Sanchez-Varo, Raquel; Sanchez-Mejias, Elisabeth; Romero, Carmen; [et al.] (2022)
    Objectives: Astrocytes are becoming crucial players in the context of neurodegenerative proteinopathies, such as Alzheimer’s disease (AD). Astroglial response has been mainly analyzed in amyloidogenic scenarios, but less ...
  • Diversity of plaque-associated myeloid cells subtypes in human alzheimer’s disease brain 

    Mejias-Ortega, Marina; Sanchez-Mejias, Elisabeth; Muñoz-Castro, Clara; Trujillo-Estrada, Laura; Vizuete, María Luisa; [et al.] (2022)
    Aims: Parenchymal microglia, as well other myeloid cells, have been postulated as a critical factor in Alzheimer´s disease (AD) pathogenesis since the identification of genetic risk factors related to their functions. ...
  • Amyloid propagation in a sporadic model of Alzheimer disease 

    Andreo-Lopez, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Huynh, Kelly; Nguyen, Marie; [et al.] (2021-11-04)
    Most age-associated neurodegenerative disorders involve the aggregation of specific proteins within the nervous system, as occurs in Alzheimer’s disease (AD). Recent evidence indicates that Aβ can misfold and aggregate ...
  • Impact of white adipose tissue in AD pathology 

    Bettinetti-Luque, Miriam; Andreo-Lopez, Juana; Cantero-Molina, Francisco; Trujillo-Estrada, Laura; Rodriguez-Ortiz, Carlos J; [et al.] (2021-11-04)
    Introduction: Alzheimer’s disease (AD) is a complex disorder and multiple cellular and molecular mechanisms are involved in AD onset and progression. Recent evidences has suggested that metabolic alterations are an important ...
  • Comparing astroglial reactivity in two transgenic mouse models of tauopathy 

    Fernandez Valenzuela, Juan José; Sanchez Varo, Raquel; López Oliva, Elba; Romero Molina, Carmen; Mejias Ortega, Marina; [et al.] (2021-11-03)
    Astrocytes are becoming crucial players in the pathology of neurodegenerative disorders, such as Alzheimer’s disease (AD). Astrocyte responses have been mainly analyzed in the context of amyloid-beta (Abeta) pathology, ...
  • Role of dopamine D4 receptor in the development of morphine-induced analgesic tolerance 

    Ponce-Velasco, Marina; Rivera-Ramirez, Alicia; Gago, Belén; Real-Aviles, Maria Angeles (2021)
    Morphine is one of the most effective analgesic used in the clinical management of pain. However, long-term use of morphine can cause many side effects including respiratory depression, constipation, analgesic tolerance, ...
  • Dopamine D4R restores morphine-induced impairment of adult neurogenesis in the subventricular zone 

    Gago, Belén; Real-Aviles, Maria Angeles; Ponce Velasco, Marina; Rivera-Ramirez, Alicia (2021)
    In the adult mammalian brain, neuroblasts from the subventricular zone (SVZ) migrate along the rostral migratory stream into the olfactory bulb, where they differentiate and synaptically integrate to contribute with the ...
  • Neuraminidase-induced neuroinflammation causes anxiety and microgliosis in the amygdala 

    León Rodríguez, Ana; Fernández-Arjona, María del Mar; Pedraza-Benítez, Maria del Carmen; Mateos-Grondona, Jesus; López-Ávalos, María Dolores (2021)
    An intracerebroventricular (ICV) injection of neuraminidase (NA) within the lateral ventricles originates an acute event of neuroinflammation, which is solved to a great extent after two weeks. Recently, neurological ...
  • Type III secretion system effectors and host specificity in Pseudomonas savastanoi pathovars of woody hosts 

    Moreno-Pérez, Alba; Murillo, Jesús; Ramos-Rodriguez, Cayo Juan (2021-09)
    The species Pseudomonas savastanoi, a member of the Pseudomonas syringae complex, includes five pathovars causing knots or excrescences in woody hosts: P. savastanoi pv. savastanoi, pv. fraxini, pv. nerii, pv. retacarpa ...
  • Fast and efficient generation of oligodendrocytes from human induced pluripotent stem cells (hiPSCs) 

    García León, Juan Antonio; Cáceres Palomo, Laura; Davila, Jose Carlos; Vitorica, Javier; Verfaillie, Catherine; [et al.] (Wiley, 2021-07)
    Oligodendrocytes (OLs) are highly specialized cells of the central nervous system responsible for myelin production and metabolic support of neurons. Defects in OLs are crucial in several neurodegenerative diseases including ...
  • Caracterización del sistema de dos componentes GacS/GacA en Pseudomonas savastanoi pv. savastanoi 

    Murillo, Jesús; Ramos, Cayo; Lavado-Benito, Carla; Martínez Gil, Marta; Rodríguez-Moreno, Luis (Sociedad Española de Microbiología, 2021)
    El sistema de dos componentes GacS/GacA es considerado uno de los principales mecanismos de regulación global en bacterias. Mayoritariamente, los trabajos de caracterización del sistema GacS/GacA se han centrado en bacterias ...
  • Microglial and neurogenic alterations in hypothalamus due to acute stress 

    Infantes-López, M. Inmaculada; Nieto-Quero, Andrea; Zambrana-Infantes, Emma; Chaves-Peña, Patricia; Tabbai-Amal, Sara; [et al.] (2021-07)
    Microglial cells are an important glial population known to be involved in several biological processes such as stress response. These cells engage an activated state following a stress insult that may lead to nervous ...
  • Anxiety and mild microglial activation in the amygdala two weeks after NA-induced neuroinflammation 

    León Rodríguez, Ana; Fernandez Arjona, Maria Del Mar; Pedraza-Benítez, Maria del Carmen; Grondona, Jesús M; Lopez Avalos, Maria Dolores; [et al.] (Wiley Periodicals, LLC, 2021-07)
    A single injection of neuraminidase (NA) within the cerebral ventricles (ICV) triggers an acute neuroinflammation. Neurological complications or behavioral alterations have been associated to neuroinflammation. While some ...
  • Coexistance of different damage-associated myeloid populations in the hippocampus of Alzheimer's patients 

    Sanchez-Mejias, Elisabet; Mejias-Ortega, Marina; Davila, Jose Carlos; Gutierrez-Perez, Antonia; Vitorica, Javier (Wiley, 2021)
    Parenchymal microglia are the brain-resident immune cells capable of responding to damage. Though the role of microglial cells in the development/progression of AD is still unknown, a dysfunctional response has recently ...
  • La rizobacteria Pseudomonas alcaligenes AVO110 induce la expresión de genes relacionados con formación de biofilms en respuesta a exudados de Rosellinia necatrix 

    Pintado, Adrian; Pérez-Martínez, Isabel; Aragón, Isabel María; Gutiérrez-Barranquero, José A.; De-Vicente-Moreno, Antonio; [et al.] (2021-06)
    La rizobacteria Pseudomonas alcaligenes AVO110 muestra antagonismo frente al hongo fitopatógeno Rosellinia necatrix. Esta cepa coloniza eficazmente las hifas de R. necatrix y es capaz de alimentarse de sus exudados. ...
  • Suitability of human-derived cells as a platform for Alzheimer's disease modeling 

    Cáceres Palomo, Laura; García León, Juan Antonio; Davila, Jose Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia (2021)
    Aims: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. Recently, ...
  • 18F-THK5351 PET imaging, neuropathology and clinical progression in a tau mouse model 

    Vegas-Gomez, Laura; Edwards III, George; Hasan, Omar; Gamez, Nazaret; Schulz, Jonathan; [et al.] (Alzheimer disease & Parkinson disease Conference 2021, 2021)
    Aims: Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. The neuropathology of AD is characterized by the extracellular deposition of ...

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