BCGF - Contribuciones a congresos científicos
Envíos recientes
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Suitability of human-derived cells as a platform for Alzheimer's disease modeling
(2021)Aims: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. Recently, ... -
18F-THK5351 PET imaging, neuropathology and clinical progression in a tau mouse model
(Alzheimer disease & Parkinson disease Conference 2021, 2021)Aims: Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. The neuropathology of AD is characterized by the extracellular deposition of ... -
Microtubule stabilization reduces amyloid pathology and improves synaptic/memory deficits in APP/PS1 mice
(Alzheimer disease & Parkinson disease Conference 2021, 2021)Aims: Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic/neuronal loss. Tau hyperphosphorylation destabilizes microtubules leading to axonal transport failure and generation of dystrophic neurites, ... -
Amyloid-β seeding and propagation processes in a hAβ-KI model of Alzheimer's disease
(Cold Spring Harbor Laboratory, 2020-12-02)Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ... -
Understanding microglial responses in the frontal cortex of alzheimer´s disease patients
(2021-03-09)Microglial cells, the immune cells of the brain, and the neuroinflammatory process associated, have been postulated as a critical factor in AD pathogenesis, since the identification of genetic risk factors related ... -
Human pluripotent stem cells as a research tool for elucidating the role of glial cells in Alzheimer´s disease
(2020-12-18)Background: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. ... -
Amyloid-b seeding and propagation processes in a hAb-KI model of Alzheimer's disease
(2020-12-17)Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ... -
Microtubule stabilization protects cognitive function and slows down the course of Alzheimer's like pathology in an amyloidogenic mouse model
(2020-12-17)Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic dysfunction and neuronal loss. In AD, the hyperphosphorylation of tau compromises axonal transport and leads to the generation of dystrophic ... -
Coexistance of different myeloid populations in the frontal cortex of alzheimer's disease patients
(2020-12-16)Parenchymal microglia, the brain-resident immune cells capable of responding to damage and disease, has been postulated as a critical factor in the Alzheimer´s disease (AD) progression. Apart from microglia, CNS macrophages, ... -
Longitudinal assessment of tau pet imaging and its correlation with neuropathology and clinical signs progression
(Cold Spring Harbor Laboratory, 2020-12-02)Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. As the world’s population increases, so does the prevalence of age-related dementias. The ... -
Mutations in LAMA5 disrupts a skeletal noncanonical focal adhesion pathway and produces a distinct bent bone dysplasia
(2020-09-24)In addition to its structural role in skeletogenesis, the extracellular matrix (ECM), particularly basement membrane proteins, facilitates communication with intracellular signaling pathways and cell to cell interactions ... -
Instituto de Biotecnología y Desarrollo Azul de la Universidad de Málaga, IBYDA: un instrumento al servicio de la docencia transversal de la economía circular
El desarrollo, a escala mundial, camina de un modelo de Economía lineal a uno circular o azul, que dé respuesta a los importantes desafíos económicos y ambientales de nuestro planeta. En 2015, la Comisión Europea ... -
Control de variables ambientales en el cultivo: implicaciones para la acuicultura. Efectos negativos del estrés en la práctica acuícola
(2019-12-20)Control de variables ambientales en el cultivo: implicaciones para la acuicultura. Efectos negativos del estrés en la práctica acuícola En la bahía de Cádiz existe una consolidada actividad de acuicultura, con un importante ... -
A viral effector suppresses cell-to-cell spread of silencing by targeting two plasmodesmal receptor-like kinases
(2019-11-15)RNA interference (RNAi) in plants can move from cell to cell, allowing for systemic spread of an anti-viral immune response. How this cell-to-cell spread of silencing is regulated is currently unknown. Here, we describe ... -
Neuraminidase-induced neuroinflammation is largely dependent on microglial TLR4 receptor
(2019-10-01)The sialidase neuraminidase (NA) cleaves terminal sialic acid from glycoproteins and glycolipids. Among its various locations, it is present in the envelope/membrane of some bacteria/viruses (e.g. influenza virus), where ... -
Host specificity in Pseudomonas savastanoi pathovars of woody hosts: comparative genomics and gene regulation
(2019-09-05)Pseudomonas savastanoi belongs to the intensively studied Pseudomonas syringae complex, and includes four pathovars causing knots or excrescences in woody hosts. These are P. savastanoi pv. savastanoi (Psv), pv. nerii ... -
Bioinformatics and transcriptomics analyses of the HrpL regulon in Pseudomonas savastanoi pathovars of woody host.
(2019-09-04)The species Pseudomonas savastanoi, a member of the Pseudomonas syringae complex, includes four pathovars causing knots or excrescences in woody hosts: P. savastanoi pv. savastanoi (Psv), pv. fraxini (Psf), pv. nerii (Psn) ... -
Biosynthesis of IAA in Pseudomonas savastanoi: a comparative genomic approach
(2019-09-04)Bacteria belonging to the Pseudomonas syringae complex cause diseases in a variety of woody and herbaceous plants. Pseudomonas savastanoi is a member of this complex and produces tumors or excrescences in the aerial parts ... -
Phenotypic heterogeneity during plant colonization
(2019-07-29)Isogenic bacterial populations can display phenotypic differences. Cell-to-cell phenotypic differences can be a consequence of noisy gene expression, or a programmed event under genetic or epigenetic control. Bistability ... -
Phenotypic heterogeneity in Pseudomonas syringae
(2019-07-29)The notion of isogenic bacterial populations displaying phenotypic differences is widely accepted today. A particular case of phenotypic heterogeneity is bistability. Bistability occurs when bacterial population splits ...