• Setting out zebrafish (Danio rerio) as a model to study nervous necrosis virus-host interaction. 

  Moreno-García, Patricia; Álvarez-Torres, Daniel; Frétaud, Maxence; Mehraz, Manon; Langevin, Christelle; Béjar-Alvarado, Julia; Alonso-Sánchez, María del Carmen[et al.] (2023)

  Viral nervous necrosis is responsible for important economic losses in aquaculture facilities. The causative agent is the nervous necrosis virus (NNV). Four NNV species have been described, although only RGNNV and SJNNV ...

• D-chiro-inositol prevents memory deficits in the 3xTg mouse model of Alzheimer’s disease in a sex-dependent manner. 

  Pacheco-Sánchez, Beatriz; Navarro, Juan Antonio; Tovar, Rubén; Rodriguez-de-Fonseca, Fernando; Rivera, Patricia (2023)

  Alzheimer’s disease (AD) is recognized as an age-related neurodegenerative disorder, characterized by the aggregation and deposition of amyloid-β (Aβ) in plaques and neurofibrillary tangles (NFTs) composed of aggregates ...

• Peripheral myeloid cells infiltrate the hippocampus of Alzheimer's disease patients. 

  Mejías-Ortega, Marina; Muñoz-Castro, Clara; Sánchez-Mejías, Elisabeth; Jimenez, Sebastian; Trujillo-Estrada, Laura Isabel; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)

  Microglia, the brain-resident myeloid cells, play a major role in the immune responses of the nervous system and in the pathogenesis of Alzheimer's disease (AD). However, the presence of peripheral myeloid cells in the AD ...

• Human and mouse seeds differentially affect AB aggregation by modulating the inflammatory response. 

  Andreo-López, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Do Huynh, Kelly; Minh Thu Nguyen, Marie; Cheung, Alwin; Pham Tran, Janine; Da Cunha, Celia; Morales-Cabello, Mario; Fatuarte Juli, Ivan; Trujillo-Estrada, Laura Isabel; Núñez Díaz, Cristina; Cadete-Martini, Alessandra; Forner, Stefania; LaFerla, Frank; Gutiérrez-Pérez, Antonia; Baglietto-Vargas, David[et al.] (2023)

  Abstract text: Alzheimer’s Disease (AD) is a neurodegenerative proteinopathy in which Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prionlike process. These amyloid aggregation ...

• Visceral adipose tissue triggers tau pathogenesis in transgenic mice through CDK5/P25 pathway. 

  Bettinetti-Luque, Miriam; Trujillo-Estrada, Laura Isabel; Andreo-López, Juana; Campos-Moreno, Cynthia; Fatuarte Juli, Ivan; Morales-Cabello, Mario; Da Cunha, Celia; Sánchez-Mejías, Elisabet; LaFerla, Frank; Gutiérrez-Pérez, Antonia; Baglietto-Vargas, David[et al.] (2023)

  Alzheimer’s disease (AD) is a complex disorder and multiple molecular mechanisms are involved in AD onset and progression. Recent evidences have suggested that metabolic alterations are an important pathological feature ...

• Co-cultures between neurons and astrocytes to address Alzheimer´s disease pathology. 

  Cáceres Palomo, Laura; García-León, Juan Antonio; Trujillo-Estrada, Laura Isabel; López Oliva, Elba; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)

  Background: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. ...

• Pharmacological activation of dopamine D4 receptor prevents morphine-induced impairment of the subventricular adult neurogenesis: functional implications in odor discrimination learning. 

  Ponce-Velasco, Marina; Rivera-Ramírez, Alicia; Real-Avilés, María Ángeles; Roza, Carolina; Gago-Calderón, Belén (2023)

  Morphine reduces adult neurogenesis in the subventricular zone (SVZ) and therefore the integration of newly generated neurons in the local olfactory bulb (OB) circuit. However, the effects of opioids drugs on the olfactory ...

• Cognitive impairment acceleration after late-life depression in a model of Alzheimer´s disease 

  Vegas-Gómez, Laura; López-Castillo, Inés; Fernández-Valenzuela, Juan José; Gutiérrez-Pérez, Antonia; Moreno-González, Inés (2023)

  Background: Clinical studies suggest that depressive symptoms could be considered an important risk factor for the future development of cognitive impairment and even Alzheimer's disease (AD). In fact, there is a strong ...

• Glia and neurons from human iPSCs to address the pathology of Alzheimer´s disease 

  García-León, Juan Antonio; Cáceres Palomo, Laura; Trujillo Estrada, Laura; López Oliva, Elba; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)

  Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. Recently, ...

• Neurons and astrocytes derived from human iPSCs to model Alzheimer´s disease 

  Cáceres Palomo, Laura; Trujillo Estrada, Laura; López Oliva, Elba; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia; García-León, Juan Antonio[et al.] (2023)

  Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. Recently, several ...

• Visceral adipose tissue triggers tau pathogenesis in transgenic mice 

  Bettinetti-Luque, Miriam; Trujillo-Estrada, Laura Isabel; Andreo-López, Juana; Cantero-Molina, Francisco; Da Cunha, Celia; Sánchez-Mejías, Elisabet; LaFerla, Frank; Gutiérrez-Pérez, Antonia; Baglietto-Vargas, David[et al.] (2023-07-19)

  Alzheimer’s disease (AD) is a complex disorder and multiple cellular and molecular mechanisms are involved in AD onset and progression. Recent evidences have suggested that metabolic alterations are an important pathological ...

• Human and mouse seeds differentially affect Aβ aggregation by modulating the inflammatory response 

  Andreo-López, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Do Huynh, Kelly; Minh Thu Nguyen, Marie; Cheung, Alwin; Pham Tran, Janine; Da Cunha, Celia; Trujillo-Estrada, Laura Isabel; Nuñez Diaz, Cristina; Cadete-Martini, Alessandra; Forner, Stefania; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2023)

  Background: Alzheimer’s Disease (AD) is a neurodegenerative proteinopathy in which Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. These amyloid aggregation ...

• Herramienta bioinformática para la identificación de motivos conservados en promotores bacterianos 

  Arroyo Mateo, Antonio; Delgado-Martín, Belén; Díaz-Martínez, Luis; Rodríguez-Moreno, Luis Gabriel; Ramos-Rodríguez, Cayo Juan (2023)

  Los factores de transcripción (FTs) son proteínas que se unen a secuencias específicas de ADN llamadas elementos reguladores, que se encuentran generalmente en las regiones promotoras de los genes. Al unirse a estos ...

• Explorando el secretoma de Pseudomonas savastanoi pv. savastanoi: Un enfoque bioinformático para el análisis de proteínas secretadas durante la interacción planta-patógeno 

  Domínguez Cerván, Hilario; Díaz-Martínez, Luis; Ramos-Rodríguez, Cayo Juan; Rodríguez-Moreno, Luis Gabriel (2023)

  La tuberculosis del olivo, causada por Pseudomonas savastanoi pv. savastanoi (Psv), se caracteriza por la formación de tumores en los troncos y ramas de las plantas infectadas. Las bacterias gramnegativas poseen mecanismos ...

• The Skeletal Atlas: A holistic approach to transcriptomics in the skeleton. 

  Perez-Tejeiro, Jose Miguel; Csukasi, Fabiana; Becerra-Ratia, José; Durán-Jimenez, Iván Jesús; Fernández-Pozo, Noé (2023)

  Gene expression atlases are powerful bioinformatics tools that allow access to the scientific community to explore omics data. In biomedicine, numerous gene expression databases are available, yet none provide enough ...

• Testing exosomes as a treatment for posthemorrhagic hydrocephalus. 

  López-de-San-Sebastián, Javier; Rodríguez-Pérez, Luis Manuel; Anguita-Guardia, Alba; Jiménez-Lara, Antonio Jesús; Páez-González, Patricia (2023)

  Germinal matrix hemorrhages and intraventricular hemorrhages (GMH/IVH) lead to posthemorrhagic hydrocephalus (PHH), a severe cause of morbidity and mortality in premature neonates. GMH/IVH disrupts the ependyma, which forms ...

• Estudio de la expresión de genes de Salmonella enterica y su efecto en la interacción con plantas. 

  Baisón-Olmo, Fernando; López-Pagán, Nieves; Beuzón-López, Carmen del Rosario; Ruiz-Albert, Francisco Javier (2023)

  Salmonella enterica es una bacteria patógena Gram negativas que causa enfermedades como la gastroenteritis o la fiebre tifoidea en diversos animales. Para desarrollar el proceso infeccioso en animales S. enterica se sirve ...

• A plant virus causes symptoms through the deployment of a host-mimicking protein domain to attract the insect vector. 

  Gao, Man; Aguilar Parras, Emmanuel; Garnelo-Gómez, Borja; Medina-Puche, Laura; Fan, Pengfei; Ontiveros, Irene; Pan, Shaojun; Tan, Huang; Von Roepenack-Lahaye, Edda; Chen, Na; Wang, Xiao-Wei; Baulcombe, David C.; Rodríguez-Bejarano, Eduardo; Díaz-Pendón, Juan Antonio; Furutani, Masahiko; Morita, Miyo Terao; Lozano-Durán, Rosa[et al.] (2023)

  During compatible plant-virus interactions, viruses can interfere with the normal developmental program of their hosts, leading to the appearance of phenotypes that we usually identify as ‘’symptoms of infection’’ (leaf ...

• The transcriptional regulator JAZ8 interacts with the C2 protein from geminiviruses and limits the geminiviral infection in Arabidopsis 

  Rosas-Díaz, Tábata Victoria; Cana Quijada, José Francisco; Wu, Mengshi; Du, Hui; Fernandez‐Barbero, Gemma; Macho, Alberto P.; Solano, Roberto; Castillo-Garriga, Araceli; Wang, Xiao-Wei; Lozano-Durán, Rosa; Rodríguez-Béjarano, Eduardo[et al.] (2023)

  Jasmonates (JAs) are phytohormones that finely regulate critical biological processes, including plant development and defense. JASMONATE ZIM-DOMAIN (JAZ) proteins are crucial transcriptional regulators that keep JA-responsive ...

• Usefulness of myeloid dendritic cells in cellular in vitro assays for evaluating immediate hypersensitivity reactions to betalactams. 

  Fernandez-Santamaría, Rubén; Ariza Veguillas, Adriana; Bogas Herrera, Gádor; Salas, María; Calvo-Serrano, Silvia; Frecha, Cecilia; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa; Fernández-Duarte, Tahía Diana[et al.] (2023)

  Introduction Dendritic cells (DCs) are the most potent antigen presenting cells (APCs) with an important role detecting, processing, and presenting antigens to T cells. The analysis of maturation after in vitro stimulation ...

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