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- Biología Celular, Genética y Fisiología - (BCGF)
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Listar BCGF - Contribuciones a congresos científicos por autor "Fernández-Llebrez, Pedro"
Mostrando ítems 1-8 de 8
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A model of neuroinflammation and demyelination by intracerebroventricular injection of microbial neuraminidase
Fernández-Llebrez, Pedro; Granados-Durán, Pablo; Gómez-Roldán, María del Carmen; Cifuentes-Rueda, Manuel; Pérez-Martín, Margarita; Mateos-Grondona, Jesús; Rodriguez-de-Fonseca, Fernando; López-Ávalos, María Dolores[et al.] (2014-07-14)Neuraminidase from Clostridium perfringens, which cleaves terminal sialic acid from carbohydrate chains, was injected in the lateral ventricle of rats. It diffused in the ipsilateral ventricle, the third ventricle, and ... -
Correlation between IL1β expression level and morphological parameters proves the usefulness of morphology measures to predict the degree of activation of microglial cells
Fernández-Arjona, María del Mar; Mateos-Grondona, Jesús; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (2017-10-04)It is well known that microglial cells undergo an important change in morphology upon activation, so that form and function are intimately related. Upon activation, microglia cell body enlarges, its ramifications shortens ... -
FGF2, but not EGF, Induces multiciliated ependymal cells to dedifferentiate and adopt radial glial features in vitro
Mateos-Grondona, Jesús; Granados-Durán, Pablo; Navarro Dueñas, Isabel; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (2014-07-21)Multiciliated ependymal cells form an epithelium lining most of the ventricular cavities of vertebrates brain. Although considered postmitotic and completely differentiated, ependymal cells maintain some phenotypic ... -
IGF-I stimulates cell proliferation in a specific area of the hypothalamic wall
Pérez-Martín, Margarita; Cifuentes-Rueda, Manuel; Mateos-Grondona, Jesús; López-Ávalos, María Dolores; Fernández-Llebrez, Pedro (2015-09-15)Neurogenesis in the adult rat hippocampal subgranular zone and the subventricular zone of the lateral ventricles has been well documented. Increasing evidence suggests that neurogenesis also occurs in the adult hypothalamus. ... -
Morphological traits of surveillant/activated microglia during an experimentally induced acute neuroinflammatory process
Fernández-Arjona, María del Mar; López-Ávalos, María Dolores; Mateos-Grondona, Jesús; Fernández-Llebrez, Pedro (2016-07-12)Several studies show that morphological changes of microglia over the course of inflammation are tightly coupled to function. However the progressive transformation into activated microglia is poorly characterized. AIMS: ... -
Neuraminidase-activated microglia compromise the viability of ependymocytes
Fernández-Arjona, María del Mar; López-Ávalos, María Dolores; Mateos-Grondona, Jesús; Carrillo-Pinzón, Cristóbal; Fernández-Llebrez, Pedro (2017-10-04)Neuraminidase (NA) is a sialidase present in the envelope/wall of some virus/bacteria responsible for brain infections, such as flu, mumps or meningitis. The intracerebroventricular injection of NA in the rat brain provokes ... -
Neuraminidase-induced neuroinflammation is largely dependent on microglial TLR4 receptor
Fernández-Arjona, María del Mar; Mateos-Grondona, Jesús; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (2019-10-01)The sialidase neuraminidase (NA) cleaves terminal sialic acid from glycoproteins and glycolipids. Among its various locations, it is present in the envelope/membrane of some bacteria/viruses (e.g. influenza virus), where ... -
The ependymal detach due to neuraminidase provokes hydrocephalus
Fernández-Arjona, María del Mar; Granados-Durán, Pablo; Gómez-Roldán, María del Carmen; López-Ávalos, María Dolores; Mateos-Grondona, Jesús; Cifuentes-Rueda, Manuel; Pérez-Martín, Margarita; Fernández-Llebrez, Pedro[et al.] (2015-05-27)Background: In many cases there seems to exist a tight relationship between the integrity of the ependymal barrier and the onset of hydrocephalus (see 1). We wanted to investigate this by means of a repetitive model that ...