- RIUMA Principal
- Investigación
- Biología Celular, Genética y Fisiología - (BCGF)
- BCGF - Contribuciones a congresos científicos
- Listar BCGF - Contribuciones a congresos científicos por autor
Listar BCGF - Contribuciones a congresos científicos por autor "Fernandez-Valenzuela, Juan José"
Mostrando ítems 1-8 de 8
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Analyzing hippocampal synaptic damage and glial response in a mouse model of tauopathy
Fernandez-Valenzuela, Juan José; Sánchez-Varo, Raquel; Navarro, Victoria; Jimenez, Sebastian; Sánchez-Mejias, Elisabeth; [et al.] (2017-10-04)Tau pathology is highly related to synaptic and neuronal loss, leading to cognitive decline and dementia in Alzheimer’s disease (AD) and other tauopathies. Tau transgenic mice are widely used to investigate the specific ... -
Comparing astroglial reactivity in two transgenic mouse models of tauopathy
Fernandez Valenzuela, Juan José; Sanchez Varo, Raquel; López Oliva, Elba; Romero Molina, Carmen; Mejias Ortega, Marina; [et al.] (2021-11-03)Astrocytes are becoming crucial players in the pathology of neurodegenerative disorders, such as Alzheimer’s disease (AD). Astrocyte responses have been mainly analyzed in the context of amyloid-beta (Abeta) pathology, ... -
Disentangling the contribution of tau and abeta pathologies in transgenic models of Alzheimer's disease
Sanchez-Varo, Raquel; Fernandez-Valenzuela, Juan José; Navarro, Victoria; Jimenez, Sebastian; Sanchez-Mejias, Elisabeth; [et al.] (2018-07-20)AIMS: Amyloid-beta (Abeta) deposits and intraneuronal hyperphosphorylated tau are major pathological hallmarks of Alzheimer’s disease (AD). The coexistence of these aggregates in AD brains leads to synaptic dysfunction, ... -
Dissecting the microglial response in transgenic models of amyloidogenesis and tauopathy
Sanchez-Varo, Raquel; Fernandez Valenzuela, Juan José; Romero-Molina, Carmen; Sanchez-Mejias, Elisabeth; Gomez-Arboledas, Angela; [et al.] (2019-07-19)Amyloid-beta (Abeta) peptide deposits and hyperphosphorylated tau protein (phospho-tau) accumulate in Alzheimer’s disease (AD) brains. These abnormal protein aggregates leads to glial activation, synaptic dysfunction, ... -
Microtubule stabilization protects cognitive function and slows down the course of Alzheimer's like pathology in an amyloidogenic mouse model
Sanchez-Varo, Raquel; Fernandez-Valenzuela, Juan José; De Castro, Vanessa; Sanchez-Mejias, Elisabeth; Nuñez-Diaz, Cristina; [et al.] (2020-12-17)Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic dysfunction and neuronal loss. In AD, the hyperphosphorylation of tau compromises axonal transport and leads to the generation of dystrophic ... -
Microtubule stabilization reduces amyloid pathology and improves synaptic/memory deficits in APP/PS1 mice
Sanchez-Varo, Raquel; Fernandez Valenzuela, Juan José; Muñoz-Castro, Clara; De Castro, Vanessa; Sanchez-Mejias, Elisabet; [et al.] (Alzheimer disease & Parkinson disease Conference 2021, 2021)Aims: Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic/neuronal loss. Tau hyperphosphorylation destabilizes microtubules leading to axonal transport failure and generation of dystrophic neurites, ... -
SYSTEMIC ADMINISTRATION OF EPOTHYLONE-D RECUES MEMORY AND AMELIORATES ALZHEIMER’S DISEASE-LIKE PATHOLOGY IN APP/PS1 MICE
Fernandez-Valenzuela, Juan José; Sanchez-Varo, Raquel; De Castro, Vanessa; Moyano, Francisco José; Vizuete, Marisa; [et al.] (2017-04-17)Aims Cognitive and memory decline in Alzheimer's disease (AD) patients is highly related to synaptic dysfunction and neuronal loss. Tau hyperphosphorylation destabilizes microtubules leading to axonal transport failure, ... -
Tau pathology and astroglial reactivity: a comparative study of two mouse models of tauopathy
Fernandez-Valenzuela, Juan José; López Oliva, Elba; Sanchez-Varo, Raquel; Sanchez-Mejias, Elisabeth; Romero, Carmen; [et al.] (2022)Objectives: Astrocytes are becoming crucial players in the context of neurodegenerative proteinopathies, such as Alzheimer’s disease (AD). Astroglial response has been mainly analyzed in amyloidogenic scenarios, but less ...