ListarBCGF - Contribuciones a congresos científicos por tema "Alzheimer"
Mostrando ítems 1-17 de 17
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Abeta from APP/PS1 Alzheimer mice hippocampus induced synaptic damage in vivo and in vitro
Sanchez-Varo, Raquel; De Castro, Vanessa; Trujillo-Estrada, Laura Isabel
; Sanchez-Mejias, Elisabet; Jimenez, Sebastian; Navarro, Victoria; Sanchez-Mico, Maria Virtudes; Gomez-Arboledas, Angela; Vizuete, Marisa; Davila, Jose Carlos; Gutierrez-Perez, Antonia[et al.] (2017-10-02)
We aim to investigate the effects of Abeta from young APP/PS1 mouse model of Alzheimer`s disease (AD) on the synaptic integrity, as the loss of synapses strongly correlates with cognitive deficits in patients. Plaque-associated ... -
Analyzing hippocampal synaptic damage and glial response in a mouse model of tauopathy
Fernandez-Valenzuela, Juan José; Sánchez-Varo, Raquel; Navarro, Victoria; Jimenez, Sebastian; Sanchez-Mejias, Elisabet; Nuñez-Diaz, Cristina; Gomez-Arboledas, Angela; Vizuete, Marisa; Davila, Jose Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2017-10-04)
Tau pathology is highly related to synaptic and neuronal loss, leading to cognitive decline and dementia in Alzheimer’s disease (AD) and other tauopathies. Tau transgenic mice are widely used to investigate the specific ... -
Coexistance of different damage-associated myeloid populations in the hippocampus of Alzheimer's patients
Sanchez-Mejias, Elisabet; Mejias-Ortega, Marina; Davila, Jose Carlos; Gutierrez-Perez, Antonia; Vitorica, Javier (Wiley, 2021)
Parenchymal microglia are the brain-resident immune cells capable of responding to damage. Though the role of microglial cells in the development/progression of AD is still unknown, a dysfunctional response has recently ... -
Coexistance of different myeloid populations in the frontal cortex of alzheimer's disease patients
Mejías-Ortega, Marina; Sanchez-Mejias, Elisabet; Nuñez-Diaz, Cristina; Trujillo-Estrada, Laura Isabel; Sanchez-Varo, Raquel; Davila, Jose Carlos; Davila, Jose Carlos; Gutierrez-Perez, Antonia[et al.] (2020-12-16)
Parenchymal microglia, the brain-resident immune cells capable of responding to damage and disease, has been postulated as a critical factor in the Alzheimer´s disease (AD) progression. Apart from microglia, CNS macrophages, ... -
Comparing astroglial reactivity in two transgenic mouse models of tauopathy
Fernandez Valenzuela, Juan José; Sanchez Varo, Raquel; López Oliva, Elba; Romero Molina, Carmen; Mejias Ortega, Marina; Sanchez-Mejias, Elisabet; Vizuete, Maria Luisa; Davila, Jose Carlos; Vitorica, Javier; Gutierrez, Antonia[et al.] (2021-11-03)
Astrocytes are becoming crucial players in the pathology of neurodegenerative disorders, such as Alzheimer’s disease (AD). Astrocyte responses have been mainly analyzed in the context of amyloid-beta (Abeta) pathology, ... -
Disentangling the contribution of tau and abeta pathologies in transgenic models of Alzheimer's disease
Sanchez-Varo, Raquel; Fernandez-Valenzuela, Juan José; Navarro, Victoria; Jimenez, Sebastian; Sanchez-Mejias, Elisabet; Nuñez-Diaz, Cristina; Gomez-Arboledas, Angela; Vizuete, Marisa; Davila, Jose Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2018-07-20)
AIMS: Amyloid-beta (Abeta) deposits and intraneuronal hyperphosphorylated tau are major pathological hallmarks of Alzheimer’s disease (AD). The coexistence of these aggregates in AD brains leads to synaptic dysfunction, ... -
Diversity of plaque-associated myeloid cells subtypes in human alzheimer’s disease brain
Mejias-Ortega, Marina; Sanchez-Mejias, Elisabet; Muñoz-Castro, Clara; Trujillo-Estrada, Laura Isabel; Vizuete, María Luisa; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2022)
Aims: Parenchymal microglia, as well other myeloid cells, have been postulated as a critical factor in Alzheimer´s disease (AD) pathogenesis since the identification of genetic risk factors related to their functions. ... -
Epothilone-d rescues cognition and attenuates alzheimer’s disease-like pathology in APP/PS1 mice
Ferbandez-Valenzuela, Juan Jose; Sanchez-Varo, Raquel; De Castro, Vanessa; Moyano, Francisco; Vizuete, Marisa; Davila, Jose Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2016-09-09)
AIMS: Cognitive decline in Alzheimer's disease (AD) patients has been linked to synaptic damage and neuronal loss. Hyperphosphorylation of tau protein destabilizes microtubules leading to the accumulation of autophagy/vesicular ... -
Fast and efficient generation of oligodendrocytes from human induced pluripotent stem cells (hiPSCs)
Garcia-Leon, Juan Antonio; Cáceres Palomo, Laura; Davila, Jose Carlos; Vitorica, Javier; Verfaillie, Catherine; Gutierrez-Perez, Antonia[et al.] (Wiley, 2021-07)
Oligodendrocytes (OLs) are highly specialized cells of the central nervous system responsible for myelin production and metabolic support of neurons. Defects in OLs are crucial in several neurodegenerative diseases including ... -
Human pluripotent stem cell-derived astrocytes from alzheimer´s disease patients for disease modeling
Cáceres Palomo, Laura; López Oliva, Elba; Davila, Jose Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia; Garcia-Leon, Juan Antonio[et al.] (2022)
Aims: The lack of reliable models of Alzheimer´s disease (AD) has impeded the development of effective therapies. Glial cells have a key role in AD pathology, but this cannot be properly modeled using available animal ... -
Human pluripotent stem cells as a research tool for elucidating the role of glial cells in Alzheimer´s disease
Garcia-Leon, Juan Antonio; Cáceres Palomo, Laura; Davila, Jose Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia (2020-12-18)
Background: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. ... -
Late-life depression is able to accelerate learning and memory impairment in a mouse model of Alzheimer´s disease
(CSHL, 2022)Clinical studies suggest that depression could be considered an important risk factor for the future development of cognitive impairment and Alzheimer's disease (AD). In fact, there is a strong association between late-life ... -
LITIO COMO TERAPIA NEUROPROTECTORA EN EL MODELO APPSL/PS1M146L DE LA ENFERMEDAD DE ALZHEIMER
Trujillo-Estrada, Laura Isabel; Baglietto-Vargas, David; Moreno González, Inés; De Castro, Vanessa; Jimenez, Sebastian; Sanchez-Varo, R; Sanchez-Mejias, Elisabet; Vizuete, M; Davila, Jose Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2013)
El litio se utiliza desde hace varias décadas en el tratamiento de trastornos bipolares y la depresión, y recientemente se debate su uso potencial en patologías neurodegenerativas como la enfermedad de Alzheimer (AD). ... -
Microtubule stabilization protects cognitive function and slows down the course of Alzheimer's like pathology in an amyloidogenic mouse model
Sanchez-Varo, Raquel; Fernandez-Valenzuela, Juan José; De Castro, Vanessa; Sanchez-Mejias, Elisabet; Nuñez-Diaz, Cristina; Gómez-Arboledas, Ángela; Moreno González, Inés; Davila, Jose Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2020-12-17)
Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic dysfunction and neuronal loss. In AD, the hyperphosphorylation of tau compromises axonal transport and leads to the generation of dystrophic ... -
SYSTEMIC ADMINISTRATION OF EPOTHYLONE-D RECUES MEMORY AND AMELIORATES ALZHEIMER’S DISEASE-LIKE PATHOLOGY IN APP/PS1 MICE
Fernandez-Valenzuela, Juan José; Sanchez-Varo, Raquel; De Castro, Vanessa; Moyano, Francisco José; Vizuete, Marisa; Davila, Jose Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2017-04-17)
Aims Cognitive and memory decline in Alzheimer's disease (AD) patients is highly related to synaptic dysfunction and neuronal loss. Tau hyperphosphorylation destabilizes microtubules leading to axonal transport failure, ... -
Tau pathology and astroglial reactivity: a comparative study of two mouse models of tauopathy
Fernandez-Valenzuela, Juan José; López Oliva, Elba; Sanchez-Varo, Raquel; Sanchez-Mejias, Elisabet; Romero, Carmen; Mejias-Ortega, Marina; Vizuete, Marisa; Davila, Jose Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2022)
Objectives: Astrocytes are becoming crucial players in the context of neurodegenerative proteinopathies, such as Alzheimer’s disease (AD). Astroglial response has been mainly analyzed in amyloidogenic scenarios, but less ... -
Understanding microglial responses in the frontal cortex of alzheimer´s disease patients
Mejias-Ortega, Marina; Sanchez-Mejias, Elisabet; Navarro, Victoria; Nuñez-Diaz, Cristina; Sanchez-Varo, Raquel; Jimenez, Sebastian; Davila, Jose Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2021-03-09)
Microglial cells, the immune cells of the brain, and the neuroinflammatory process associated, have been postulated as a critical factor in AD pathogenesis, since the identification of genetic risk factors related ...