• 18F-THK5351 PET imaging, neuropathology and clinical progression in a tau mouse model 

      Vegas-Gomez, Laura; Edwards III, George; Hasan, Omar; Gamez, Nazaret; Schulz, Jonathan; [et al.] (Alzheimer disease & Parkinson disease Conference 2021, 2021)
      Aims: Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. The neuropathology of AD is characterized by the extracellular deposition of ...
    • Abeta from APP/PS1 Alzheimer mice hippocampus induced synaptic damage in vivo and in vitro 

      Sanchez-Varo, Raquel; De Castro, Vanessa; Trujillo-Estrada, Laura; Sanchez-Mejias, Elisabeth; Jimenez, Sebastian; [et al.] (2017-10-02)
      We aim to investigate the effects of Abeta from young APP/PS1 mouse model of Alzheimer`s disease (AD) on the synaptic integrity, as the loss of synapses strongly correlates with cognitive deficits in patients. Plaque-associated ...
    • Amyloid propagation in a sporadic model of Alzheimer disease 

      Andreo-Lopez, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Huynh, Kelly; Nguyen, Marie; [et al.] (2021-11-04)
      Most age-associated neurodegenerative disorders involve the aggregation of specific proteins within the nervous system, as occurs in Alzheimer’s disease (AD). Recent evidence indicates that Aβ can misfold and aggregate ...
    • Analyzing hippocampal synaptic damage and glial response in a mouse model of tauopathy 

      Fernandez-Valenzuela, Juan José; Sánchez-Varo, Raquel; Navarro, Victoria; Jimenez, Sebastian; Sánchez-Mejias, Elisabeth; [et al.] (2017-10-04)
      Tau pathology is highly related to synaptic and neuronal loss, leading to cognitive decline and dementia in Alzheimer’s disease (AD) and other tauopathies. Tau transgenic mice are widely used to investigate the specific ...
    • Comparing astroglial reactivity in two transgenic mouse models of tauopathy 

      Fernandez Valenzuela, Juan José; Sanchez Varo, Raquel; López Oliva, Elba; Romero Molina, Carmen; Mejias Ortega, Marina; [et al.] (2021-11-03)
      Astrocytes are becoming crucial players in the pathology of neurodegenerative disorders, such as Alzheimer’s disease (AD). Astrocyte responses have been mainly analyzed in the context of amyloid-beta (Abeta) pathology, ...
    • Decoding damage-associated microglia in post mortem hippocampus of Alzheimer’s disease patients 

      Sanchez-Mejias, Elisabeth; Mejias-Ortega, Marina; Navarro, Victoria; Gomez-Arboledas, Angela; Nuñez-Diaz, Cristina; [et al.] (2019-07-18)
      The relationship between Alzheimer’s disease (AD) and neuroinflammation has become stronger since the identification of several genetic risk factors related to microglial function. Though the role of microglial cells in ...
    • Diversity of plaque-associated myeloid cells subtypes in human alzheimer’s disease brain 

      Mejias-Ortega, Marina; Sanchez-Mejias, Elisabeth; Muñoz-Castro, Clara; Trujillo-Estrada, Laura; Vizuete, María Luisa; [et al.] (2022)
      Aims: Parenchymal microglia, as well other myeloid cells, have been postulated as a critical factor in Alzheimer´s disease (AD) pathogenesis since the identification of genetic risk factors related to their functions. ...
    • Epothilone-d rescues cognition and attenuates alzheimer’s disease-like pathology in APP/PS1 mice 

      Ferbandez-Valenzuela, Juan Jose; Sanchez-Varo, Raquel; De Castro, Vanessa; Moyano, Francisco; Vizuete, Marisa; [et al.] (2016-09-09)
      AIMS: Cognitive decline in Alzheimer's disease (AD) patients has been linked to synaptic damage and neuronal loss. Hyperphosphorylation of tau protein destabilizes microtubules leading to the accumulation of autophagy/vesicular ...
    • Human amyloid seeds aggregate more efficient than seeds from old 3xtg-ad mice 

      Andreo-Lopez, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Huynh, Kelly; Thu Nguyen, Marie Minh; [et al.] (2022)
      Aims: Most age-associated neurodegenerative disorders involve the aggregation of specific proteins within the nervous system, as occurs in Alzheimer’s disease (AD). Recent evidence indicates that Aβ can misfold and aggregate ...
    • Human pluripotent stem cell-derived astrocytes from alzheimer´s disease patients for disease modeling 

      Cáceres Palomo, Laura; López Oliva, Elba; Davila, Jose Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia; [et al.] (2022)
      Aims: The lack of reliable models of Alzheimer´s disease (AD) has impeded the development of effective therapies. Glial cells have a key role in AD pathology, but this cannot be properly modeled using available animal ...
    • Human pluripotent stem cells as a research tool for elucidating the role of glial cells in Alzheimer´s disease 

      García León, Juan Antonio; Cáceres Palomo, Laura; Davila, Jose Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia (2020-12-18)
      Background: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. ...
    • Impact of white adipose tissue in AD pathology 

      Bettinetti-Luque, Miriam; Trujillo-Estrada, Laura; Andreo-Lopez, Juana; Cantero-Molina, Francisco; Rodriguez-Ortiz, Carlos J; [et al.] (2022)
      Aims: Alzheimer’s disease (AD) is a complex disorder and multiple cellular and molecular mechanisms are involved in AD onset and progression. Recent evidences has suggested that metabolic alterations are an important ...
    • Impact of white adipose tissue in AD pathology 

      Bettinetti-Luque, Miriam; Andreo-Lopez, Juana; Cantero-Molina, Francisco; Trujillo-Estrada, Laura; Rodriguez-Ortiz, Carlos J; [et al.] (2021-11-04)
      Introduction: Alzheimer’s disease (AD) is a complex disorder and multiple cellular and molecular mechanisms are involved in AD onset and progression. Recent evidences has suggested that metabolic alterations are an important ...
    • Lithium, as a neuroprotective therapy for Alzheimer’s disease pathology, modifies abeta plaque toxicity 

      Trujillo-Estrada, Laura; De Castro, Vanessa; Jimenez, Sebastian; Sanchez-Varo, Raquel; Sanchez-Mejias, Elisabet; [et al.] (2014-07-02)
      BACKGROUND: Despite the relatively large information about the Alzheimer’s disease (AD) pathology, no effective disease-modifying treatment has been yet developed. Lithium, a primary drug to treat bipolar disorder, has ...
    • Microglial responses in the human Alzheimer’s disease frontal cortex 

      Mejias-Ortega, Marina; Sanchez-Mejias, Elisabeth; Navarro, Victoria; Nuñez-Diaz, Cristina; Gomez-Arboledas, Angela; [et al.] (2019-07-17)
      The continuing failure to develop an effective treatment for Alzheimer’s disease (AD) reveals the complexity for this pathology. Increasing evidence indicates that neuroinflammation involving particularly microglial ...
    • Suitability of human-derived cells as a platform for Alzheimer's disease modeling 

      Cáceres Palomo, Laura; García León, Juan Antonio; Davila, Jose Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia (2021)
      Aims: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. Recently, ...
    • SYSTEMIC ADMINISTRATION OF EPOTHYLONE-D RECUES MEMORY AND AMELIORATES ALZHEIMER’S DISEASE-LIKE PATHOLOGY IN APP/PS1 MICE 

      Fernandez-Valenzuela, Juan José; Sanchez-Varo, Raquel; De Castro, Vanessa; Moyano, Francisco José; Vizuete, Marisa; [et al.] (2017-04-17)
      Aims Cognitive and memory decline in Alzheimer's disease (AD) patients is highly related to synaptic dysfunction and neuronal loss. Tau hyperphosphorylation destabilizes microtubules leading to axonal transport failure, ...
    • Tau pathology and astroglial reactivity: a comparative study of two mouse models of tauopathy 

      Fernandez-Valenzuela, Juan José; López Oliva, Elba; Sanchez-Varo, Raquel; Sanchez-Mejias, Elisabeth; Romero, Carmen; [et al.] (2022)
      Objectives: Astrocytes are becoming crucial players in the context of neurodegenerative proteinopathies, such as Alzheimer’s disease (AD). Astroglial response has been mainly analyzed in amyloidogenic scenarios, but less ...